2016
The emerging role of microRNAs in hypoxia-induced pulmonary hypertension
Mohsenin V. The emerging role of microRNAs in hypoxia-induced pulmonary hypertension. Sleep And Breathing 2016, 20: 1059-1067. PMID: 27154628, DOI: 10.1007/s11325-016-1351-y.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionHypoxia-induced pulmonary hypertensionPulmonary hypertensionArterial hypertensionHeart failureRole of microRNAsMechanism of PHPulmonary arterial blood pressurePulmonary arterial smooth muscle cellsDevelopment of PHIdiopathic pulmonary arterial hypertensionChronic obstructive lung diseasePathogenesis of PHArterial smooth muscle cellsRight heart failureRight ventricular dysfunctionPoor prognostic signArterial blood pressureCongestive heart failureObstructive lung diseaseSleep-disordered breathingSetting of hypoxiaAberrant vascular remodelingQuality of lifeSmooth muscle cells
2015
Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology
Kholdani C, Fares WH, Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology. Pulmonary Circulation 2015, 5: 220-227. PMID: 26064448, PMCID: PMC4449234, DOI: 10.1086/679995.Peer-Reviewed Original ResearchObstructive sleep apneaPulmonary hypertensionPulmonary venous hypertensionVenous hypertensionSleep apneaSetting of OSAPulmonary artery pressurePoor prognostic signHypoxic pulmonary vasoconstrictionMajority of patientsLeft heart dysfunctionAberrant vascular remodelingQuality of lifeResult of apneaVascular cell proliferationArtery pressurePulmonary vasoconstrictionEjection fractionIntermittent hypoxiaPrognostic signHeart dysfunctionLeft heartHigh prevalenceHypertensionVascular remodeling