2024
Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased risk
2023
Short-term neonatal outcomes of pregnancies complicated by maternal obesity
Dinsmoor M, Ugwu L, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Short-term neonatal outcomes of pregnancies complicated by maternal obesity. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100874. PMID: 36690180, PMCID: PMC10065915, DOI: 10.1016/j.ajogmf.2023.100874.Peer-Reviewed Original ResearchConceptsComposite neonatal morbidityNeonatal outcomesBody mass indexWeeks of gestationMaternal obesityNeonatal morbidityMorbid obesityMass indexReference groupIntraventricular hemorrhage grade 3Short-term neonatal outcomesCohort of deliveriesComposite neonatal outcomeSuper morbid obesityHypoxic-ischemic encephalopathyPrevious cesarean deliveryRespiratory distress syndromeChronic hypertensionPreterm deliveryBaseline characteristicsCesarean deliveryComposite outcomeMaternal heightMaternal preeclampsiaObese patients
2022
Hypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita ATN, Silver RM, El‐Sayed Y, Wapner R, Rouse DJ, Saade GR, Thorp JM, Costantine M, Chien EK, Casey BM, Srinivas SK, Swamy GK, Simhan HN, Health H. Hypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial. BJOG An International Journal Of Obstetrics & Gynaecology 2022, 129: 1396-1403. PMID: 34927787, PMCID: PMC9207156, DOI: 10.1111/1471-0528.17059.Peer-Reviewed Original ResearchConceptsAdverse maternal outcomesLow-risk nulliparous womenHypertensive disordersMaternal outcomesSecondary outcomesNulliparous womenAdverse outcomesComposite adverse maternal outcomeIntensive care unit admissionSecondary analysisCare unit admissionSevere neonatal complicationsWeeks of gestationMode of deliveryNulliparous individualsMaternal compositeNeonatal complicationsPerinatal compositePostpartum infectionUnit admissionCaesarean deliveryExpectant managementPlacental abruptionVenous thromboembolismGestational age
2015
A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery
Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthMaternal single nucleotide polymorphismsSPTB casesPreterm birthValidation cohortSingle nucleotide polymorphismsEarly spontaneous preterm deliveryP-valueTerm controlsTerm delivery controlsSpontaneous preterm deliveryMother-infant pairsCase-control studyIndependent validation cohortRace/ethnicityPreterm deliveryInfant morbidityMaternal ageControl groupMultiple testing adjustmentMultiple comparisonsCohortBirthNucleotide polymorphismsGenome-wide association studies