2024
Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy
Greenland P, Segal M, McNeil R, Parker C, Pemberton V, Grobman W, Silver R, Simhan H, Saade G, Ganz P, Mehta P, Catov J, Merz C, Varagic J, Khan S, Parry S, Reddy U, Mercer B, Wapner R, Haas D. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy. JAMA Cardiology 2024, 9 PMID: 38958943, PMCID: PMC11223045, DOI: 10.1001/jamacardio.2024.1621.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveCase-control studyHypertensive disordersEarly pregnancyClinical dataSmall-for-gestational-age infantsPrediction of hypertensive disordersSmall-for-gestational-ageHypertensive disorders of pregnancyPrediction of HDPDisorders of pregnancyNested case-control studyPlasma samplesMulticenter observational studyStored plasma samplesReceiver operating characteristic curveBody mass indexGestational hypertensionNon-Hispanic blacksPreterm birthFetal sexFirst-trimesterNon-Hispanic whitesPregnancy outcomesMaternal raceDesign, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study
Group T, Scholtens D, LeBlanc E, Vesco K, Amy D, Bays K, Massimino S, Robinson S, Schell K, Walters G, Hillier T, Oshiro C, Cordero S, Howick C, Kim L, Martinez Y, Pishchalenko O, Wastlova V, Zork N, Mourad M, Lonier J, Reddy U, Acevedo J, Castillo J, Gomez M, Peguero B, Facco F, Feghali M, Bocan H, Stramowski S, Powe C, Edlow A, Barth W, Nathan D, Azevedo R, Baez A, Iroajanma C, Larkin M, Maya J, Michalopolous C, Neamonitaki N, Thangthaeng N, Yee L, Lowe W, Grobman W, Szmuilowicz E, Aguirre A, Guevara E, Mallett G, Matos S, Tyagi S, Spadola A, Catalano P, Azimirad A, Werner E, Rouse D, Malloy M, Parra F, Sherr J, Merriam A, Bitterman S, Considine E, Leventhal J, Perley L, Rink L, Steffen A, Thompson B, Zgorski M, Steffes M, Arends V, Killeen A, Siddique J, Bustamante P, Cheung Y, Freeze C, Grott T, Kuang A, Tull M, Linder B. Design, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study. BMJ Open 2024, 14: e084216. PMID: 38851233, PMCID: PMC11163666, DOI: 10.1136/bmjopen-2024-084216.Peer-Reviewed Original ResearchConceptsLarge-for-gestational-age birth weightMetabolic outcomesLarge-for-gestational-ageDiagnosis of gestational diabetesOral glucose tolerance testAdverse pregnancy outcomesVanderbilt University Institutional Review BoardCourse of pregnancyObservational cohort studyGlucose tolerance testNational Institute of DiabetesDigestive and Kidney DiseasesGDM treatmentWeeks gestationDetect such abnormalitiesPerinatal outcomesGDM screeningInstitutional review boardGestational diabetesFirst-trimesterPregnancy outcomesEarly pregnancyGlucose abnormalitiesBirth weightPregnant adultsGenetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased riskPregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks Gestation
Woolcock H, Parra N, Zhang Y, Reddy U, Bello N, Miller E, Booker W. Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks Gestation. American Journal Of Perinatology 2024 PMID: 38569509, DOI: 10.1055/a-2298-5347.Peer-Reviewed Original ResearchAssociated with adverse pregnancy outcomesFetal growth restrictionPlacental abruptionWeeks gestationBlood pressureElevated BPAmerican Heart AssociationPregnancy outcomesNormal BPOdds of fetal growth restrictionIncreased riskOdds of placental abruptionAmerican CollegeMultivariable-adjusted odds ratioAssociated with HDPAdverse pregnancy outcomesWeeks of pregnancyProspective cohort studyElevated blood pressureConfidence intervalsStage I hypertensionAmerican College of Cardiology (ACCCesarean deliveryPreterm deliverySingleton pregnanciesAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2
2023
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. JAMA 2023, 330: 2191-2199. PMID: 38085313, PMCID: PMC10716715, DOI: 10.1001/jama.2023.21146.Peer-Reviewed Original ResearchConceptsPrimary composite outcomeAdverse pregnancy outcomesComposite outcomeFirst trimesterCannabis exposurePregnancy outcomesCannabis usePlacental functionPropensity score-weighted analysisNulliparous Pregnancy Outcomes StudyOngoing exposureMaternal cannabis useUrine cotinine assayUrine samplesMedical record abstractionPregnancy outcome dataGestational-age birthsBody mass indexGestational age windowsPregnancy Outcomes StudyUS medical centersOngoing cannabis useAdjudication of outcomesMaternal cannabisHypertensive disordersSearching and visualizing genetic associations of pregnancy traits by using GnuMoM2b
Yan Q, Guerrero R, Khan R, Surujnarine A, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Blue N, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b. Genetics 2023, 225: iyad151. PMID: 37602697, PMCID: PMC10691790, DOI: 10.1093/genetics/iyad151.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesNulliparous Pregnancy Outcomes StudyPregnancy Outcomes StudyMajor risk factorGenome-wide association studiesPregnancy outcomesGenetic associationMonitoring MothersRisk factorsOutcome studiesWomen's healthPhenome-wide association studySingle nucleotide polymorphismsAssociation studiesGenetic resultsPregnancyNucleotide polymorphismsAssociation of Living in a Food Desert and Poor Periconceptional Diet Quality in a Cohort of Nulliparous Pregnant Individuals
Venkatesh K, Walker D, Yee L, Wu J, Garner J, McNeil B, Haas D, Mercer B, Reddy U, Silver R, Wapner R, Saade G, Parry S, Simhan H, Lindsay K, Grobman W. Association of Living in a Food Desert and Poor Periconceptional Diet Quality in a Cohort of Nulliparous Pregnant Individuals. Journal Of Nutrition 2023, 153: 2432-2441. PMID: 37364682, PMCID: PMC10447609, DOI: 10.1016/j.tjnut.2023.06.032.Peer-Reviewed Original ResearchConceptsDiet qualityPregnant individualsDietary qualityNulliparous Pregnancy Outcomes StudyWorse dietary qualityAdverse pregnancy outcomesHealthy Eating IndexPregnancy Outcomes StudyAdverse social determinantsFood desertsPregnancy outcomesProspective cohortTotal vegetablesMean HEIMonitoring MothersLowest quartileOutcome studiesPoor dietExcess intakeEmpty caloriesSocial determinantsAdequacy componentsAssessed individualsSupermarket accessFood access indicators
2022
Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women
Makarem N, Chau K, Miller E, Gyamfi-Bannerman C, Tous I, Booker W, Catov J, Haas D, Grobman W, Levine L, McNeil R, Merz C, Reddy U, Wapner R, Wong M, Bello N. Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women. JAMA Network Open 2022, 5: e2248165. PMID: 36547978, PMCID: PMC9857221, DOI: 10.1001/jamanetworkopen.2022.48165.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesMediterranean diet patternTime of conceptionPregnancy outcomesDiet patternLower oddsAMED scoresGestational diabetesCohort studyUS womenLower riskRisk of APOsPrepregnancy body mass indexCardiovascular disease risk factorsSemiquantitative food frequency questionnaireAlternate Mediterranean diet scoreNulliparous Pregnancy Outcomes StudyLowest AMED scoresGestational age infantsDisease risk factorsDose-response associationFood frequency questionnaireMediterranean diet scoreBody mass indexCause of morbidityAssociation of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension
Hauspurg A, Marsh D, McNeil R, Bairey Merz C, Greenland P, Straub A, Rouse C, Grobman W, Pemberton V, Silver R, Chen Y, Mercer B, Levine L, Hameed A, Hoffman M, Simhan H, Catov J, Reddy U, Willinger M, Davis M, Laposky A, Iams J, Dalton W, Latimer C, Polito L, Louis J, Wapner R, Fuchs K, Torres C, Lynch S, Onativia A, DiVito M, Nhan-Chang C, Basner R, Haas D, Foroud T, Perkins E, Barnes S, Winters A, McCormick C, Schubert F, Caritis S, Bickus M, Speer P, Emery S, Daftary A, Facco F, Peaceman A, Zee P, Campbell P, Shepard J, Williams C, Wing D, Wadhwa P, Nageotte M, Chung J, Rumney P, Porto M, Pham V, Parry S, Ludmir J, Elovitz M, Peters M, Araujo B, Pien G, Esplin M, Vorwaller K, Postma J, Morby V, Williams M, Meadows L, Parker C, Koch M, McFadden D, Alexander B, Yetukuri V, Hunter S, Holder T, Franklin H, DeCain M, Griggs C, Redline S, Mobley D, Surovec S, Ulanski J, Saade G. Association of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension. JAMA Cardiology 2022, 7: 268-276. PMID: 35044418, PMCID: PMC8771430, DOI: 10.1001/jamacardio.2021.5617.Peer-Reviewed Original ResearchConceptsHigher NT-proBNP concentrationsNT-proBNP concentrationsHypertensive disordersSubclinical cardiac dysfunctionEarly pregnancyYear post partumHypertension 2Lower riskPregnancy outcomesCohort studyCardiac dysfunctionNatriuretic peptideN-terminal pro-brain natriuretic peptide concentrationN-terminal pro-brain natriuretic peptideEarly pregnancy body mass indexProspective multicenter observational studyPro-brain natriuretic peptidePost partumNulliparous Pregnancy Outcomes StudyFirst-trimester blood samplesAdverse pregnancy outcomesMulticenter observational studyFuture cardiovascular diseaseNatriuretic peptide concentrationsCardiovascular disease risk
2021
1072 Early pregnancy BMI and angiogenesis-related biomarkers (sFlt-1/PlGF): a pathway for adverse pregnancy outcomes?
Beck C, Allshouse A, Blue N, Grobman W, Reddy U, Simhan H, Haas D, Mercer B, Silver R. 1072 Early pregnancy BMI and angiogenesis-related biomarkers (sFlt-1/PlGF): a pathway for adverse pregnancy outcomes? American Journal Of Obstetrics And Gynecology 2021, 224: s662-s663. DOI: 10.1016/j.ajog.2020.12.1097.Peer-Reviewed Original Research
2020
Prospective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes
Silver R, Hunter S, Reddy U, Facco F, Gibbins K, Grobman W, Mercer B, Haas D, Simhan H, Parry S, Wapner R, Louis J, Chung J, Pien G, Schubert F, Saade G, Zee P, Redline S, Parker C. Prospective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes. Obstetrical & Gynecological Survey 2020, 75: 139-141. DOI: 10.1097/ogx.0000000000000782.Peer-Reviewed Original ResearchObstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009)
College of Obstetricians and Gynecologists A, with S, Metz TD, Berry RS, Fretts RC, Reddy UM, Turrentine MA. Obstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009). American Journal Of Obstetrics And Gynecology 2020, 222: b2-b20. PMID: 32004519, DOI: 10.1016/j.ajog.2020.01.017.Peer-Reviewed Original ResearchObstetric historyCommon adverse pregnancy outcomesNon-Hispanic black raceMaternal obstetric historyObstetric Care ConsensusAdverse pregnancy outcomesPast obstetric historyPrevalent risk factorsMale fetal sexAdvanced maternal ageTiming of deliveryHealth care providersPeer support groupsMental health professionalsChronic hypertensionMultiple gestationsPregnancy outcomesGestational ageBlack raceMaternal ageRisk factorsDefinite causeUnmarried statusHistologic examinationUmbilical cord1102: Adverse pregnancy outcomes and adherence to diet and exercise recommendations for cardiovascular health
Lauder J, Theilen L, Allshouse A, Simhan H, Grobman W, Mercer B, Wapner R, Parry S, Haas D, Chung J, Reddy U, Saade G, Silver R. 1102: Adverse pregnancy outcomes and adherence to diet and exercise recommendations for cardiovascular health. American Journal Of Obstetrics And Gynecology 2020, 222: s679. DOI: 10.1016/j.ajog.2019.11.1114.Peer-Reviewed Original Research
2015
Does the Presence of a Condition-Specific Obstetric Protocol Lead to Detectable Improvements in Pregnancy Outcomes?
Bailit J, Grobman W, McGee P, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Iams J, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S. Does the Presence of a Condition-Specific Obstetric Protocol Lead to Detectable Improvements in Pregnancy Outcomes? Obstetrical & Gynecological Survey 2015, 70: 679-680. DOI: 10.1097/01.ogx.0000473082.76430.62.Peer-Reviewed Original ResearchPostpartum hemorrhageSpecific complicationsHemorrhage protocolShoulder dystociaIntensive care unit admissionCare unit admissionRate of hemorrhageRisk-adjusted patient outcomesShoulder dystocia maneuversObstetric protocolsUnit admissionObstetric outcomesSevere hypertensionCohort studyPregnancy outcomesBlood lossSingle centerPatient outcomesImproved outcomesHigh-quality protocolsComplicationsHospitalSecondary analysisHemorrhagePatient safetyThe association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study
Miller R, Smiley R, Thom E, Grobman W, Iams J, Mercer B, Saade G, Tita A, Reddy U, Rouse D, Sorokin Y, Blackwell S, Esplin, Tolosa J, Caritis, Network E. The association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 122: 1387-1394. PMID: 25600430, PMCID: PMC4508241, DOI: 10.1111/1471-0528.13243.Peer-Reviewed Original ResearchConceptsShort cervixCervical lengthAR genotypeMaternal-Fetal Medicine Units NetworkEunice Kennedy Shriver National InstituteNormal cervical lengthShort cervical lengthShort cervix groupPreterm birth riskCase-control studyRace/ethnicitySpontaneous PTBNulliparous womenPregnancy outcomesPreterm birthTransvaginal sonogramsPrimary outcomePTB riskSecond trimesterAncillary studiesChild healthBirth riskCervixAdrenoceptor genotypeControl group
2010
Pregnancy Outcomes in Infertile Couples
Signore C, Reddy U. Pregnancy Outcomes in Infertile Couples. 2010, 715-725. DOI: 10.1007/978-1-4419-1436-1_49.Peer-Reviewed Original ResearchAssisted Reproductive TechnologyART pregnanciesHigh riskLong-term child healthReasonable pregnancy ratesSingleton ART pregnanciesNumber of embryosPerinatal outcomesMultiple gestationsPregnancy outcomesSingleton pregnanciesAdverse outcomesART mothersObserved complicationsHealthy childrenInfertility treatmentPregnancy rateInfertile couplesChild healthPregnancyReproductive technologiesDevelopmental problemsComplicationsOutcomesRecent data