2024
Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death
Cersonsky T, Ayala N, Tucker N, Saade G, Dudley D, Pinar H, Silver R, Reddy U, Lewkowitz A. Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2024, 303: 159-164. PMID: 39488137, PMCID: PMC11602338, DOI: 10.1016/j.ejogrb.2024.10.037.Peer-Reviewed Original ResearchRisk of stillbirthCause of deathIncreased risk of stillbirthHypertensive disordersPrenatal visit scheduleStillbirth Collaborative Research NetworkHigher risk of stillbirthSuboptimal prenatal careHypertensive disorders of pregnancyAssociated with higher riskDisorders of pregnancyVisit adherenceVisitation guidelinesPrenatal careSecondary analysisNon-adherenceVisit scheduleStillbirthIncreased riskMultivariate regressionStudy objectiveVisit frequencyPregnancyAdherenceGuidelinesCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetric Anesthesia Digest 2024, 44: 139-140. DOI: 10.1097/01.aoa.0001026572.72882.bd.Peer-Reviewed Original ResearchExposure to cannabisCannabis usePlacental functionPregnancy outcomesPrevalence of cannabis usePoor fetal growthAdverse pregnancy outcomesInfluence pregnancy outcomePlacental dysfunctionCannabis exposureFetal growthPregnant individualsSelf-reported useTobacco useCannabisDrug usePregnancyOutcome relationsPotential legal consequencesOutcomesAssociationExposureUseDysfunctionPublished researchDiet quality, community food access, and glycemic control among nulliparous individuals with diabetes
Venkatesh K, Yee L, Wu J, Joseph J, Garner J, McNeil R, Scifres C, Mercer B, Reddy U, Silver R, Saade G, Parry S, Simhan H, Post R, Walker D, Grobman W. Diet quality, community food access, and glycemic control among nulliparous individuals with diabetes. Primary Care Diabetes 2024, 18: 506-510. PMID: 38972826, DOI: 10.1016/j.pcd.2024.06.011.Peer-Reviewed Original ResearchStillbirth: we can do better
Silver R, Reddy U. Stillbirth: we can do better. American Journal Of Obstetrics And Gynecology 2024, 231: 152-165. PMID: 38789073, DOI: 10.1016/j.ajog.2024.05.042.Peer-Reviewed Original ResearchResource countriesNon-Hispanic blacksPrevention of stillbirthNon-Hispanic whitesOther Pacific IslanderRate of stillbirthLow-income countriesStillbirth rateStillbirthRisk factorsPacific IslandersGenetic etiologyPlacental assessmentEmotion managementRisk stratificationPreventionUnited StatesPregnancyRiskDisparitiesEpidemiologyCountriesU.S.WhitePrediction of metabolic syndrome following a first pregnancy
Kawakita T, Greenland P, Pemberton V, Grobman W, Silver R, Bairey Merz C, McNeil R, Haas D, Reddy U, Simhan H, Saade G. Prediction of metabolic syndrome following a first pregnancy. American Journal Of Obstetrics And Gynecology 2024, 231: 649.e1-649.e19. PMID: 38527600, PMCID: PMC11424779, DOI: 10.1016/j.ajog.2024.03.031.Peer-Reviewed Original ResearchDevelopment of metabolic syndromeArea under the receiver operating characteristic curveMetabolic syndromeNational Cholesterol Education Program Adult Treatment Panel III criteriaAdult Treatment Panel III criteriaPrevalence of metabolic syndromePrediction of metabolic syndromeProspective cohort studyIn-personSecondary analysisCohort studyIII criteriaInclusion criteriaPregnant individualsPrimary outcomeReceiver operating characteristic curveVisit 2Regression modelsPregnancySyndromeDeliveryUnited StatesCharacteristic curveLASSO regression modelYears441 Association of nocturnal heart rate and development of gestational diabetes and hypertensive disorders of pregnancy
Fisher S, Huang X, Khan S, Grimaldi D, Zee P, Greenland P, Facco F, Basner R, Chung J, Grobman W, McNeil R, Pien G, Reddy U, Redline S, Silver R, Yee L. 441 Association of nocturnal heart rate and development of gestational diabetes and hypertensive disorders of pregnancy. American Journal Of Obstetrics And Gynecology 2024, 230: s242-s243. DOI: 10.1016/j.ajog.2023.11.467.Peer-Reviewed Original Research456 Association of Restless Legs Syndrome in Pregnancy with Cardiovascular Health 2-7 years after first birth
Friedlander R, Huang X, Kim M, Khan S, Zee P, Greenland P, Bello N, Catov J, Gibbs B, Grobman W, Haas D, Levine L, McNeil R, Mercer B, Merz N, Miller E, Reddy U, Saade G, Silver R, Yee L. 456 Association of Restless Legs Syndrome in Pregnancy with Cardiovascular Health 2-7 years after first birth. American Journal Of Obstetrics And Gynecology 2024, 230: s251. DOI: 10.1016/j.ajog.2023.11.482.Peer-Reviewed Original Research
2023
Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b
Yan Q, Guerrero R, Khan R, Surujnarine A, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Blue N, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b. Genetics 2023, 225: iyad151. PMID: 37602697, PMCID: PMC10691790, DOI: 10.1093/genetics/iyad151.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesNulliparous Pregnancy Outcomes StudyPregnancy Outcomes StudyMajor risk factorGenome-wide association studiesPregnancy outcomesGenetic associationMonitoring MothersRisk factorsOutcome studiesWomen's healthPhenome-wide association studySingle nucleotide polymorphismsAssociation studiesGenetic resultsPregnancyNucleotide polymorphismsHypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Constantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Hypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial. Obstetric Anesthesia Digest 2023, 43: 82-82. DOI: 10.1097/01.aoa.0000927856.60760.92.Peer-Reviewed Original ResearchLow-risk patientsLow-risk nulliparous womenHypertensive disordersMaternal morbidityMaternal outcomesNulliparous womenControlled TrialsWeeks' gestationAdverse outcomesLower riskSecondary analysisPregnancyPatientsHDPOutcomesRecent studiesHypertensionMorbidityGestationMortalityPrevalenceTrialsWeeksWomen
2022
Treatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 634-636. DOI: 10.1097/01.ogx.0000899456.24100.71.Peer-Reviewed Original ResearchHypertension During PregnancyAcute kidney injuryAdverse neonatal outcomesChronic hypertensionKidney injuryMaternal outcomesNeonatal outcomesPlacental abruptionPreterm birthHeart failureMaternal deathsGestational agePerinatal deathPulmonary edemaPregnancyBlack womenDeathOutcomesHypertensionAbruptionPreeclampsiaEdemaInjuryStrokeWomenTreatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 460-462. DOI: 10.1097/01.ogx.0000852888.79526.c3.Peer-Reviewed Original ResearchA Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection
Hughes B, Clifton R, Rouse D, Saade G, Dinsmoor M, Reddy U, Pass R, Allard D, Mallett G, Fette L, Gyamfi-Bannerman C, Varner M, Goodnight W, Tita A, Costantine M, Swamy G, Gibbs R, Chien E, Chauhan S, El-Sayed Y, Casey B, Parry S, Simhan H, Napolitano P, Macones G. A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection. Obstetrical & Gynecological Survey 2022, 77: 16-18. DOI: 10.1097/01.ogx.0000805168.83387.d5.Peer-Reviewed Original Research
2021
Health Resource Utilization of Labor Induction Versus Expectant Management
Grobman W, Sandoval G, Reddy U, Tita A, Silver R, Mallett G, Hill K, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Iams J, Chien E, Casey B, Gibbs R, Srinivas S, Swamy G, Simhan H, Macones G. Health Resource Utilization of Labor Induction Versus Expectant Management. Obstetric Anesthesia Digest 2021, 41: 34-34. DOI: 10.1097/01.aoa.0000732480.32100.cf.Peer-Reviewed Original ResearchExpectant managementElective inductionNulliparous womenLow-risk nulliparous womenHealth care resource utilizationHealth resource utilizationNeonatal respiratory morbidityElective labor inductionARRIVE trialDelivery admissionHypertensive disordersCesarean deliveryLabor inductionRespiratory morbidityWeeks postpartumTrialsManagement trialsWeeksWomenInductionCurrent studyResource utilizationAntepartumMorbidityPregnancy
2019
Early Preterm Preeclampsia Outcomes by Intended Mode of Delivery
Coviello E, Iqbal S, Grantz K, Huang C, Landy H, Reddy U. Early Preterm Preeclampsia Outcomes by Intended Mode of Delivery. Obstetric Anesthesia Digest 2019, 39: 187-188. DOI: 10.1097/01.aoa.0000603672.77426.4d.Peer-Reviewed Original ResearchSevere featuresEarly preterm deliveryEarly preterm preeclampsiaEarly preterm birthElevated liver enzymesSyndrome of hemolysisIntended modePreeclampsia outcomesNeonatal outcomesPregnant patientsPreterm deliveryPreterm preeclampsiaPreterm birthLow plateletsMaternal mortalityLiver enzymesPaucity of studiesPreeclampsiaOutcomesDeliveryEclampsiaMorbidityPatientsPregnancySyndromePredictors of Sleep-disordered Breathing in Pregnancy
Louis J, Koch M, Reddy U, Silver R, Parker C, Facco F, Redline S, Nhan-Chang C, Chung J, Pien G, Basner R, Grobman W, Wing D, Simhan H, Haas D, Mercer B, Parry S, Mobley D, Carper B, Saade G, Schubert F, Zee P. Predictors of Sleep-disordered Breathing in Pregnancy. Obstetric Anesthesia Digest 2019, 39: 36-37. DOI: 10.1097/01.aoa.0000552909.82459.b1.Peer-Reviewed Original ResearchSleep-disordered breathingDiagnosis of SDBSevere maternal morbidityRisk of complicationsMaternal morbidityPreterm deliverySDB symptomsVenous thromboembolismMaternal deathsOvernight polysomnographyPregnant womenAdverse outcomesLarge cohortFeasible prediction modelPregnancyBreathingWomenThromboembolismPreeclampsiaMorbidityComplicationsPolysomnographyCohortSymptomsDiagnosis
2017
Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes
Reddy U, Davis J, Ren Z, Greene M. Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes. Obstetrical & Gynecological Survey 2017, 72: 703-705. DOI: 10.1097/ogx.0000000000000517.Peer-Reviewed Original ResearchNeonatal abstinence syndromeOpioid useAbstinence syndromeChildhood outcomesEunice Kennedy Shriver National InstituteOpioid use disorderMaternal-fetal medicineMarch of DimesAffected womenAmerican CollegeChild healthUse disordersAmerican AcademyDisease controlPregnancyNational InstituteSyndromeOutcomesGynecologistsObstetriciansPediatricsPreventionWomenTreatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy
Casey B, Thom E, Peaceman A, Varner M, Sorokin Y, Hirtz D, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Iams J, Mercer B, Tolosa J, Caritis S, VanDorsten J. Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy. Obstetrical & Gynecological Survey 2017, 72: 464-465. DOI: 10.1097/01.ogx.0000521861.32334.43.Peer-Reviewed Original ResearchPharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study
Manuck T, Watkins W, Esplin, Biggio J, Bukowski R, Parry S, Zhan H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy U, Ilekis J, Yandell M, Varner M, Jorde L, Research T. Pharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2017, 125: 343-350. PMID: 28139890, DOI: 10.1111/1471-0528.14485.Peer-Reviewed Original ResearchConceptsRecurrent preterm birthPreterm birthSuccessful prolongationDefinition ADefinition BSingleton spontaneous preterm birthSpontaneous preterm birthTertiary care centerCase-control studyWhole-exome sequencingUntreated pregnanciesGestational ageHydroxyprogesterone caproateSignificant prolongationPregnancyExome sequencingProlongationWomenPharmacogenetic genesBirthGene ontology pathwaysIntegrated DiscoveryOntology pathwaysNovel analytic approach188: Neonatal outcomes for pregnancies complicated by fetal cardiac anomalies according to attempted route of delivery
Parikh L, Grantz K, Iqbal S, Huang C, Fries M, Landy H, Reddy U. 188: Neonatal outcomes for pregnancies complicated by fetal cardiac anomalies according to attempted route of delivery. American Journal Of Obstetrics And Gynecology 2017, 216: s122. DOI: 10.1016/j.ajog.2016.11.092.Peer-Reviewed Original Research
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGH