A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas
Rosenblatt K, Zhang Z, Doss R, Gurnani P, Grobman W, Silver R, Parry S, Reddy U, Cao S, Haas D. A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas. American Journal Of Obstetrics And Gynecology 2024 PMID: 38789072, DOI: 10.1016/j.ajog.2024.05.032.Peer-Reviewed Original ResearchIn vitro diagnostic multivariate index assaySpontaneous preterm birthGestational agePreterm birthLow riskModerate riskPrediction of spontaneous preterm birthHR groupRisk ratioHigh riskMonitoring Mothers-to-BeNulliparous Pregnancy Outcomes StudyTrimester of pregnancyMultivariate index assayPregnancy Outcomes StudyNested case-control designStatistically significant differencePregnant patientsWeeks gestationMass spectrometry assayCase-control designRisk stratificationStratify riskMothers-to-beStratification toolSocioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease
Venkatesh K, Khan S, Catov J, Wu J, McNeil R, Greenland P, Wu J, Levine L, Yee L, Simhan H, Haas D, Reddy U, Saade G, Silver R, Merz C, Grobman W. Socioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease. American Journal Of Obstetrics And Gynecology 2024 PMID: 38759711, DOI: 10.1016/j.ajog.2024.05.007.Peer-Reviewed Original ResearchSocial determinants of healthArea Deprivation IndexNeighborhood-level socioeconomic disadvantageSocioeconomic disadvantageSocial determinantsFramingham risk scoreRisk scoreCardiovascular diseaseNeighborhood-level social determinantsModified Poisson regression modelsDeterminants of healthParticipant's home addressMedian area deprivation indexMaternal cardiovascular healthPoisson regression modelsLong-term cardiovascular diseaseRisk of cardiovascular diseaseMothers-to-bePredicted riskRisk of ASCVDCensus block levelRisk of long-term cardiovascular diseaseMultivariate linear regressionDeprivation indexNulliparous individuals