Association of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia
Casey B, Mele L, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S. Association of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia. American Journal Of Perinatology 2024, 41: e3326-e3332. PMID: 38228158, PMCID: PMC11153033, DOI: 10.1055/s-0043-1778037.Peer-Reviewed Original ResearchUrinary iodine concentrationSubclinical hypothyroidismSubclinical thyroid diseasePregnant patientsIodine statusIodine insufficiencyThyroid diseaseIodine concentrationMaternal urinary iodine concentrationPrimary outcomePlacebo-controlled treatment trialMaternal iodine statusMild iodine insufficiencyIntelligence quotientFull-scale intelligence quotientYears of ageDifferential Ability Scales-IISingleton gestationsDouble-maskedIdentical placeboLevothyroxine replacementWeeks gestationMaternal urineThyroid screeningSerum thyrotropin