2024
A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas
Rosenblatt K, Zhang Z, Doss R, Gurnani P, Grobman W, Silver R, Parry S, Reddy U, Cao S, Haas D. A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas. American Journal Of Obstetrics And Gynecology 2024 PMID: 38789072, PMCID: PMC11584339, DOI: 10.1016/j.ajog.2024.05.032.Peer-Reviewed Original ResearchIn vitro diagnostic multivariate index assaySpontaneous preterm birthGestational agePreterm birthLow riskModerate riskPrediction of spontaneous preterm birthHR groupRisk ratioHigh riskMonitoring Mothers-to-BeNulliparous Pregnancy Outcomes StudyTrimester of pregnancyMultivariate index assayPregnancy Outcomes StudyNested case-control designStatistically significant differencePregnant patientsWeeks gestationMass spectrometry assayCase-control designRisk stratificationStratify riskMothers-to-beStratification toolAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2
2023
Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight
Venkatesh K, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Grobman W. Neighborhood Socioeconomic Disadvantage and Abnormal Birth Weight. Obstetrics And Gynecology 2023, 142: 1199-1207. PMID: 37769319, PMCID: PMC10972636, DOI: 10.1097/aog.0000000000005384.Peer-Reviewed Original ResearchAbnormal birth weightNeighborhood socioeconomic disadvantageGestational ageBirth weightPregnant individualsADI quartileIncreased oddsSocioeconomic disadvantageWeeks of gestationPotential confounding variablesLogistic regression modelsHigher area deprivationSGA neonatesLGA neonatesMultinomial logistic regression modelsSingleton gestationsCohort enrollmentAnalytic populationParticipant's addressFetal sexConfounding variablesSecondary analysisArea deprivationNeonatesQuartileAssociation between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals
Delgado A, Kendle A, Randis T, Donda K, Salemi J, Facco F, Parker C, Reddy U, Silver R, Basner R, Chung J, Schubert F, Pien G, Redline S, Parry S, Grobman W, Zee P, Louis J. Association between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals. American Journal Of Perinatology 2023, 41: e2418-e2426. PMID: 37380034, DOI: 10.1055/a-2115-0147.Peer-Reviewed Original ResearchSleep-disordered breathingAdverse neonatal outcomesNeonatal outcomesPrimary outcomeRisk ratioApnea-hypopnea indexRespiratory distress syndromeBody mass indexEvents/hConfidence intervalsSleep Disordered BreathingLog-binomial regressionNulliparous individualsHome sleep studiesChronic hypertensionNeonatal morbidityNew onsetPregestational diabetesComposite outcomeRespiratory supportTransient tachypneaDistress syndromeGestational ageMass indexMaternal riskMacroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination
Cersonsky T, Silver R, Saade G, Dudley D, Reddy U, Pinar H. Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination. Placenta 2023, 140: 60-65. PMID: 37536149, PMCID: PMC10530266, DOI: 10.1016/j.placenta.2023.07.296.Peer-Reviewed Original ResearchConceptsFetal vascular malperfusionMaternal vascular malperfusionVascular malperfusionLive birthsFVM lesionsGestational ageMacroscopic findingsAmsterdam Placental Workshop Group Consensus StatementStillbirth Collaborative Research NetworkMicroscopic histopathological examinationMicroscopic pathologic evaluationHistory of hypertensionOdds of stillbirthGroup Consensus StatementMultivariate logistic regressionMVM lesionsPathologic evaluationHistopathological examinationMaternal raceOdds ratioConsensus statementHigher oddsUmbilical cordStillbirthMaternal factorsFetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use?
Leon-Martinez D, Lundsberg L, Culhane J, Zhang J, Son M, Reddy U. Fetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use? American Journal Of Obstetrics And Gynecology 2023, 229: 678.e1-678.e16. PMID: 37348779, DOI: 10.1016/j.ajog.2023.06.035.Peer-Reviewed Original ResearchConceptsNeonatal composite outcomeComposite outcomeFetal growth restrictionGestational ageFetal weightWeeks of gestationPositive likelihood ratioGrowth restrictionNonanomalous singleton pregnanciesPoor neonatal outcomeRetrospective cohort studySingle academic centerWeeks of deliveryDays of deliveryFetal growth referencesElectronic medical recordsProportion of fetusesLikelihood ratioNeonatal morbidityNeonatal outcomesPerinatal outcomesCohort studySingleton pregnanciesNeonatal dataMedical recordsPlacental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network
Cersonsky T, Cersonsky R, Saade G, Silver R, Reddy U, Goldenberg R, Dudley D, Pinar H. Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network. Placenta 2023, 137: 59-64. PMID: 37080046, PMCID: PMC10192128, DOI: 10.1016/j.placenta.2023.04.005.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkGestational agePlacental lesionsDifferent gestational agesCollaborative research networksResearch NetworkTerm stillbirthFetal mortalityPlacental featuresHistologic changesStillbirthLesionsWeeksStandard protocolPlacentaFurther investigationAgePrincipal covariatesPrevious studiesGestationMortalityThe Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes
Costantine M, Tita A, Mele L, Casey B, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Rouse D, Sibai B, Mercer B, Caritis S, Bethesda F. The Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes. American Journal Of Perinatology 2023, 41: e1313-e1323. PMID: 36791785, PMCID: PMC10425571, DOI: 10.1055/s-0043-1761920.Peer-Reviewed Original ResearchYears of ageChild intelligence quotientSecondary outcomesBirth weightHead circumferenceNeurodevelopmental outcomesPrimary outcomeGestational ageHypothyroid disordersPopulation nomogramsGestational age birth weightIntelligence quotientHigher body mass indexLGA birth weightSGA birth weightInfant birth weightAdverse neurodevelopmental outcomesBody mass indexLarger head circumferenceFetal growth standardsOdds of childrenDetection of newbornsFetal Growth StudiesAGA neonatesSGA neonates
2022
Copy number variants and fetal growth in stillbirths
Dalton S, Workalemahu T, Allshouse A, Page J, Reddy U, Saade G, Pinar H, Goldenberg R, Dudley D, Silver R. Copy number variants and fetal growth in stillbirths. American Journal Of Obstetrics And Gynecology 2022, 228: 579.e1-579.e11. PMID: 36356697, PMCID: PMC10149588, DOI: 10.1016/j.ajog.2022.11.1274.Peer-Reviewed Original ResearchConceptsAbnormal copy number variantsFetal growth abnormalitiesGestational ageOdds ratioStillbirth Collaborative Research NetworkGenetic abnormalitiesChromosomal microarrayGestational age outcomesGestational age infantsGrowth abnormalitiesClinical risk factorsCohort study designAdjusted odds ratioCopy number variantsUnknown clinical significancePathogenic copy number variantsPlacental insufficiencyAge infantsNumber variantsFetal growthMaternal ageRisk factorsClinical significanceHigh incidenceStillbirthTreatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 634-636. DOI: 10.1097/01.ogx.0000899456.24100.71.Peer-Reviewed Original ResearchHypertension During PregnancyAcute kidney injuryAdverse neonatal outcomesChronic hypertensionKidney injuryMaternal outcomesNeonatal outcomesPlacental abruptionPreterm birthHeart failureMaternal deathsGestational agePerinatal deathPulmonary edemaPregnancyBlack womenDeathOutcomesHypertensionAbruptionPreeclampsiaEdemaInjuryStrokeWomenHypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita ATN, Silver RM, El‐Sayed Y, Wapner R, Rouse DJ, Saade GR, Thorp JM, Costantine M, Chien EK, Casey BM, Srinivas SK, Swamy GK, Simhan HN, Health H. Hypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial. BJOG An International Journal Of Obstetrics & Gynaecology 2022, 129: 1396-1403. PMID: 34927787, PMCID: PMC9207156, DOI: 10.1111/1471-0528.17059.Peer-Reviewed Original ResearchConceptsAdverse maternal outcomesLow-risk nulliparous womenHypertensive disordersMaternal outcomesSecondary outcomesNulliparous womenAdverse outcomesComposite adverse maternal outcomeIntensive care unit admissionSecondary analysisCare unit admissionSevere neonatal complicationsWeeks of gestationMode of deliveryNulliparous individualsMaternal compositeNeonatal complicationsPerinatal compositePostpartum infectionUnit admissionCaesarean deliveryExpectant managementPlacental abruptionVenous thromboembolismGestational age
2021
Outcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes
Bartal M, Ugwu LG, Grobman WA, Bailit JL, Reddy UM, Wapner RJ, Varner MW, Thorp JM, Caritis SN, Prasad M, Tita ATN, Saade GR, Rouse DJ. Outcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes. Obstetrics And Gynecology 2021, 138: 725-731. PMID: 34619719, PMCID: PMC8542618, DOI: 10.1097/aog.0000000000004561.Peer-Reviewed Original ResearchMeSH KeywordsAdultChorioamnionitisCohort StudiesEndometritisEnterocolitis, NecrotizingFemaleFetal Membranes, Premature RuptureGestational AgeHumansInfant, NewbornInfant, PrematureOutcome Assessment, Health CarePerinatal MortalityPregnancyPregnancy OutcomePregnancy, TwinPremature BirthSepsisVenous ThromboembolismWound InfectionYoung AdultConceptsComposite maternal morbidityPreterm prelabor ruptureWeeks of gestationNeonatal morbidityPreterm PROMSingleton gestationsMaternal morbidityPrelabor ruptureTwin gestationsOdds ratioComposite major neonatal morbidityComposite neonatal morbidityMajor neonatal morbidityMedian gestational ageMedian latency periodMajor fetal anomaliesAdjusted odds ratioCoprimary outcomesObstetric cohortNeonatal outcomesTwin neonatesGestational agePotential confoundersFetal anomaliesMorbidity
2020
Obstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009)
College of Obstetricians and Gynecologists A, with S, Metz TD, Berry RS, Fretts RC, Reddy UM, Turrentine MA. Obstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009). American Journal Of Obstetrics And Gynecology 2020, 222: b2-b20. PMID: 32004519, DOI: 10.1016/j.ajog.2020.01.017.Peer-Reviewed Original ResearchObstetric historyCommon adverse pregnancy outcomesNon-Hispanic black raceMaternal obstetric historyObstetric Care ConsensusAdverse pregnancy outcomesPast obstetric historyPrevalent risk factorsMale fetal sexAdvanced maternal ageTiming of deliveryHealth care providersPeer support groupsMental health professionalsChronic hypertensionMultiple gestationsPregnancy outcomesGestational ageBlack raceMaternal ageRisk factorsDefinite causeUnmarried statusHistologic examinationUmbilical cord
2017
Altered fetal growth, placental abnormalities, and stillbirth
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Altered fetal growth, placental abnormalities, and stillbirth. PLOS ONE 2017, 12: e0182874. PMID: 28820889, PMCID: PMC5562325, DOI: 10.1371/journal.pone.0182874.Peer-Reviewed Original ResearchConceptsFetal growth abnormalitiesAltered fetal growthFetal growthLive birthsPlacental abnormalitiesPlacental findingsGrowth abnormalitiesImpaired placental functionSingleton live birthsCase-control studyCause of deathPatterns of associationSingleton stillbirthsPlacental examinationTerm stillbirthGestational ageRisk factorsPerinatal pathologistsPlacental functionClinical careStillbirthAbnormalitiesStandardized protocolBirthDeathNeonatal Outcomes by Attempted Mode of Delivery and Obstetric Intervention for Pregnancies Affected by Spina Bifida [19R]
Spiliopoulos M, Iqbal S, Reddy U, Landy H, Huang C. Neonatal Outcomes by Attempted Mode of Delivery and Obstetric Intervention for Pregnancies Affected by Spina Bifida [19R]. Obstetrics And Gynecology 2017, 129: 188s. DOI: 10.1097/01.aog.0000514163.09127.5e.Peer-Reviewed Original ResearchImmediate neonatal outcomeNeonatal outcomesCesarean deliveryMode of deliveryVaginal deliverySpina bifidaInduced laborLabor induction groupRetrospective cohort studyPrevious cesarean deliveryInduction of laborMultivariable logistic regressionWeeks of gestationYears of ageSafe Labor studyNICU admissionCesarean sectionCohort studyRespiratory morbiditySingleton pregnanciesSpontaneous laborBreech deliveryGestational ageObstetric interventionsBirth traumaPharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study
Manuck T, Watkins W, Esplin, Biggio J, Bukowski R, Parry S, Zhan H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy U, Ilekis J, Yandell M, Varner M, Jorde L, Research T. Pharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2017, 125: 343-350. PMID: 28139890, DOI: 10.1111/1471-0528.14485.Peer-Reviewed Original ResearchConceptsRecurrent preterm birthPreterm birthSuccessful prolongationDefinition ADefinition BSingleton spontaneous preterm birthSpontaneous preterm birthTertiary care centerCase-control studyWhole-exome sequencingUntreated pregnanciesGestational ageHydroxyprogesterone caproateSignificant prolongationPregnancyExome sequencingProlongationWomenPharmacogenetic genesBirthGene ontology pathwaysIntegrated DiscoveryOntology pathwaysNovel analytic approach
2015
Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 214: 376.e1-376.e8. PMID: 26692181, PMCID: PMC4803498, DOI: 10.1016/j.ajog.2015.12.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrevious spontaneous preterm birthRecurrent spontaneous preterm birthDelivery gestational ageRecurrent preterm birthPreterm birthSimilar gestational ageGestational ageHydroxyprogesterone caproateSingleton spontaneous preterm birthEarly spontaneous preterm birthFirst-degree family historyPreterm birth preventionHigh-risk womenPlanned secondary analysisPredictors of responseChi-square testPenultimate pregnancyPregnancy characteristicsNeonatal morbidityPregnancy coursePreterm pregnanciesBirth preventionCurrent pregnancyRegression modelsThe phenotype of spontaneous preterm birth: application of a clinical phenotyping tool
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: 487.e1-487.e11. PMID: 25687564, PMCID: PMC4456184, DOI: 10.1016/j.ajog.2015.02.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthInfection/inflammationDecidual hemorrhageGestational ageCervical insufficiencyPreterm birthWeeks' gestationPlacental dysfunctionWhite womenMaternal stressSingleton spontaneous preterm birthDelivery gestational ageFinal common pathwayAfrican American womenMaternal comorbiditiesPremature ruptureProspective studyPlanned analysisUterine distentionClinical dataMultiple possible causesGestationHemorrhageComprehensive classification system
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sitesFetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study
Bukowski R, Hansen NI, Willinger M, Reddy UM, Parker CB, Pinar H, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Rowland Hogue CJ, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study. PLOS Medicine 2014, 11: e1001633. PMID: 24755550, PMCID: PMC3995658, DOI: 10.1371/journal.pmed.1001633.Peer-Reviewed Original ResearchConceptsRisk of stillbirthCase-control studyFetal growthGestational ageLive birthsSevere SGAPopulation-based case-control studyStillbirth prevention strategiesExcessive fetal growthSingleton live birthsFetal growth abnormalitiesNormal fetal growthStillbirth risk factorsGestational age estimatesTiming of deathLGA pregnanciesSingleton stillbirthsIndividualized normsTerm pregnancy