2024
Oxytocin regimen used for induction of labor and pregnancy outcomes
REDDY U, SANDOVAL G, TITA A, SILVER R, MALLETT G, Hill K, EL-SAYED Y, RICE M, WAPNER R, ROUSE D, SAADE G, THORP J, CHAUHAN S, COSTANTINE M, CHIEN E, CASEY B, SRINIVAS S, SWAMY G, SIMHAN H, MACONES G, GROBMAN W, Network E. Oxytocin regimen used for induction of labor and pregnancy outcomes. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101508. PMID: 39357802, DOI: 10.1016/j.ajogmf.2024.101508.Peer-Reviewed Original ResearchInduction of laborLow-risk nulliparous patientsOxytocin regimensAdjusted relative risksAdjusted odds ratiosCesarean deliveryComposite of perinatal deathConfidence intervalsNeonatal respiratory supportLow-dose regimensHigh-dose oxytocin regimenSevere neonatal complicationsOperative vaginal delivery rateFrequency of cesarean deliverySecondary analysisEstimate adjusted relative risksElective induction of laborPerinatal deathRoutine induction of labourEstimate adjusted odds ratiosVaginal delivery rateRespiratory supportNulliparous patientsMHD groupMultivariable Poisson regressionBlood Pressure Control in Pregnant Patients with Chronic Hypertension and Diabetes: Should <130/80 be the Target?
Harper L, Kuo H, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Galis Z, Ambalavanan N, Oparil S, Szychowski J, Tita A. Blood Pressure Control in Pregnant Patients with Chronic Hypertension and Diabetes: Should <130/80 be the Target? American Journal Of Obstetrics And Gynecology 2024 PMID: 39288828, DOI: 10.1016/j.ajog.2024.09.006.Peer-Reviewed Original ResearchTarget blood pressureNeonatal intensive care unitLow blood pressure groupBlood pressure groupPerinatal outcomesAverage blood pressureChronic hypertensionMm HgBlood pressureCesarean deliveryNeonatal deathDiastolic BPRisk of NICU admissionCompare perinatal outcomesEvaluate risk ratiosLt;130/80 mm HgPreterm birth <Adverse perinatal outcomesMultivariable log-binomial regression modelsGoal blood pressureAverage diastolic BPPrimary composite outcomeSystolic BP <Log-binomial regression modelsAntenatal blood pressureOptimizing Opioid Prescription Quantity After Cesarean Delivery
Smid M, Clifton R, Rood K, Srinivas S, Simhan H, Casey B, Longo M, Landau R, MacPherson C, Bartholomew A, Sowles A, Reddy U, Rouse D, Bailit J, Thorp J, Chauhan S, Saade G, Grobman W, Macones G. Optimizing Opioid Prescription Quantity After Cesarean Delivery. Obstetrics And Gynecology 2024, 144: 195-205. PMID: 38857509, PMCID: PMC11257794, DOI: 10.1097/aog.0000000000005649.Peer-Reviewed Original ResearchOpioid tabletsCesarean birthOpioid useHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkPrimary outcomeQuantity of opioid tabletsEunice Kennedy Shriver National Institute of Child HealthOpioid prescription protocolPostcesarean pain managementHistory of opioid useOpioid prescription quantitiesRandomized controlled noninferiority trialNational Institute of Child HealthInstitute of Child HealthPostcesarean analgesiaCesarean deliveryRandomized controlled trialsPain managementPrescription quantitiesFollow-upWeeks postdischargeNoninferiority trialDecision makingChild healthInduction of labor versus expectant management among low-risk patients with one prior cesarean delivery
Ukoha E, Wen T, Reddy U. Induction of labor versus expectant management among low-risk patients with one prior cesarean delivery. American Journal Of Obstetrics And Gynecology 2024 PMID: 38852849, DOI: 10.1016/j.ajog.2024.06.001.Peer-Reviewed Original ResearchInduction of laborNeonatal morbidity compositeOperative vaginal deliveryMaternal morbidity compositeVaginal deliveryExposure of interestCesarean deliveryIntensive care unit admissionMorbidity compositeWeeks 6 daysWeeks 0 daysExpectant management groupLow-risk patientsPeripartum hysterectomyUterine ruptureLikelihood of vaginal deliveryRate of uterine ruptureUnit admissionElective induction of laborLog-binomial regression modelsBirth certificate dataConfidence intervalsExpectant managementAssociated with increased likelihoodNeonatal morbidity outcomesPregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks, Gestation
Woolcock H, Parra N, Zhang Y, Reddy U, Bello N, Miller E, Booker W. Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks, Gestation. American Journal Of Perinatology 2024, 41: 2135-2143. PMID: 38569509, PMCID: PMC11496016, DOI: 10.1055/a-2298-5347.Peer-Reviewed Original ResearchAssociated with adverse pregnancy outcomesFetal growth restrictionPlacental abruptionWeeks gestationBlood pressureElevated BPAmerican Heart AssociationPregnancy outcomesNormal BPOdds of fetal growth restrictionIncreased riskOdds of placental abruptionAmerican CollegeMultivariable-adjusted odds ratioAssociated with HDPAdverse pregnancy outcomesWeeks of pregnancyProspective cohort studyElevated blood pressureConfidence intervalsStage I hypertensionAmerican College of Cardiology (ACCCesarean deliveryPreterm deliverySingleton pregnancies
2023
Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial
SANDOVAL G, GROBMAN W, EVANS S, RICE M, CLIFTON R, CHAUHAN S, COSTANTINE M, GIBSON K, LONGO M, METZ T, MILLER E, PARRY S, REDDY U, ROUSE D, SIMHAN H, THORP J, TITA A, SAADE G, Network E. Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial. American Journal Of Obstetrics And Gynecology 2023, 230: 370.e1-370.e12. PMID: 37741532, PMCID: PMC10939984, DOI: 10.1016/j.ajog.2023.09.016.Peer-Reviewed Original ResearchElective inductionARRIVE trialCesarean deliverySecondary outcomesPrimary outcomeVaginal deliveryDesirability of outcomeEunice Kennedy Shriver National InstituteSpontaneous vaginal deliverySevere neonatal complicationsWeeks of gestationOperative vaginal deliveryBetter overall outcomesPerson-centred careNeonatal complicationsObstetric trialsExpectant managementPerinatal deathRandomized trialsDecreased riskPoor outcomeClinical trialsChild healthTreatment scoresOutcome rankingsRisk factors and perinatal outcomes for persistent placenta previa in nulliparas
Post R, Chang J, Ziogas A, Crosland B, Silver R, Haas D, Grobman W, Saade G, Reddy U, Simhan H, Chung J. Risk factors and perinatal outcomes for persistent placenta previa in nulliparas. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101136. PMID: 37598887, DOI: 10.1016/j.ajogmf.2023.101136.Peer-Reviewed Original ResearchPersistent placenta previaPlacenta previaMidtrimester ultrasoundRisk factorsPrevious pregnancyCesarean deliveryMaternal ageNulliparous Pregnancy Outcomes StudyLower neonatal birthweightOlder maternal agePrevious cesarean deliveryProspective cohort studyPregnancy Outcomes StudySignificant risk factorsMultivariate logistic regressionNulliparous individualsPrevious dilationNeonatal birthweightNeonatal outcomesPerinatal outcomesPreterm deliveryBaseline characteristicsCohort studyThird trimesterAntepartum admissionsAssociation of maternal body mass index with success and outcomes of attempted operative vaginal delivery
Grasch J, Venkatesh K, Grobman W, Silver R, Saade G, Mercer B, Yee L, Scifres C, Parry S, Simhan H, Reddy U, Frey H. Association of maternal body mass index with success and outcomes of attempted operative vaginal delivery. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101081. PMID: 37422004, DOI: 10.1016/j.ajogmf.2023.101081.Peer-Reviewed Original ResearchConceptsMaternal body mass indexBody mass indexOperative vaginal deliveryVaginal delivery attemptComposite maternal morbidityComposite neonatal morbidityVaginal deliveryMass indexNeonatal morbidityCesarean deliveryMaternal morbidityAdverse outcomesSecond-stage cesarean deliveryBody mass index groupsBody mass index categoriesNulliparous Pregnancy Outcomes StudyNonanomalous singleton pregnanciesNeonatal adverse outcomesMultivariable logistic regressionPregnancy Outcomes StudyNulliparous individualsDose-dependent mannerSecondary outcomesSingleton pregnanciesPrimary outcomeMaternal and Delivery Characteristics and Self-Reported Perceived Control During Labor
Mallett G, Hill K, Doherty L, Grobman W, Reddy U, Tita A, Silver R, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H, Macones G. Maternal and Delivery Characteristics and Self-Reported Perceived Control During Labor. Obstetrics And Gynecology 2023, 142: 117-124. PMID: 37290106, PMCID: PMC10330140, DOI: 10.1097/aog.0000000000005230.Peer-Reviewed Original ResearchConceptsBody mass indexWeeks of gestationLabor Agentry ScaleScale scoreLabor painPrivate health insuranceDelivery characteristicsLabor pain scoresPrevious pregnancy lossSpontaneous vaginal deliverySevere neonatal complicationsHealth insuranceMode of deliveryFinal multivariable modelMultivariable linear regressionSelf-administered questionnaireSelf-reported raceNeonatal complicationsExpectant managementPain scoresLabor inductionNonprivate insuranceOperative deliveryCesarean deliveryVaginal deliveryOutcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy
Bushman E, Grobman W, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Outcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101032. PMID: 37244639, PMCID: PMC10521213, DOI: 10.1016/j.ajogmf.2023.101032.Peer-Reviewed Original ResearchConceptsPrelabor cesarean deliveryHypertensive disordersInduction of laborCesarean deliveryLabor inductionNeonatal morbidityInduction groupMedian durationVaginal deliveryWeeks' gestationSecondary analysisAdverse composite outcomeComposite maternal morbidityOutcome of inductionPreterm hypertensive disordersHalf of patientsCesarean delivery groupLength of inductionOptimal delivery approachMaternal morbidityComposite outcomeFetal malpresentationMultiple gestationsPreterm birthSecondary outcomesShort-term neonatal outcomes of pregnancies complicated by maternal obesity
Dinsmoor M, Ugwu L, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Short-term neonatal outcomes of pregnancies complicated by maternal obesity. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100874. PMID: 36690180, PMCID: PMC10065915, DOI: 10.1016/j.ajogmf.2023.100874.Peer-Reviewed Original ResearchConceptsComposite neonatal morbidityNeonatal outcomesBody mass indexWeeks of gestationMaternal obesityNeonatal morbidityMorbid obesityMass indexReference groupIntraventricular hemorrhage grade 3Short-term neonatal outcomesCohort of deliveriesComposite neonatal outcomeSuper morbid obesityHypoxic-ischemic encephalopathyPrevious cesarean deliveryRespiratory distress syndromeChronic hypertensionPreterm deliveryBaseline characteristicsCesarean deliveryComposite outcomeMaternal heightMaternal preeclampsiaObese patients
2022
Association of Social Determinants of Health and Clinical Factors with Postpartum Hospital Readmissions among Nulliparous Individuals
Kumar N, Grobman W, Haas D, Silver R, Reddy U, Simhan H, Wing D, Mercer B, Yee L. Association of Social Determinants of Health and Clinical Factors with Postpartum Hospital Readmissions among Nulliparous Individuals. American Journal Of Perinatology 2022, 40: 348-355. PMID: 36427510, DOI: 10.1055/s-0042-1758485.Peer-Reviewed Original ResearchConceptsPostpartum readmissionSocial determinantsHypertensive disordersHigher oddsMulticenter prospective cohort studyPostpartum hospital readmissionProspective cohort studyInitial hospital dischargeHemorrhage requiring transfusionSuch risk factorsAntecedent diagnosisHDP patientsNulliparous participantsGestational diabetesIntrapartum complicationsPerinatal morbidityCesarean deliveryCohort studyHospital dischargeClinical factorsHospital readmissionPrimary outcomeBivariable analysisModifiable factorsInsurance status
2021
Maternal and Neonatal Outcomes in Nulliparous Participants Undergoing Labor Induction by Cervical Ripening Method
Andrikopoulou M, Bushman E, Rice M, Grobman W, Reddy U, Silver R, El-Sayed Y, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Maternal and Neonatal Outcomes in Nulliparous Participants Undergoing Labor Induction by Cervical Ripening Method. American Journal Of Perinatology 2021, 40: 1061-1070. PMID: 34352922, PMCID: PMC8817048, DOI: 10.1055/s-0041-1732379.Peer-Reviewed Original ResearchConceptsAdverse neonatal outcomesCervical ripeningNeonatal outcomesLabor inductionNulliparous participantsComposite outcomeAdverse maternal outcomesCervical ripening methodsMaternal composite outcomeNeonatal composite outcomeLow-risk womenLength of laborConcurrent oxytocinCoprimary outcomesNeonatal compositeExpectant managementMaternal outcomesCesarean deliverySecondary outcomesFetal demisePatient characteristicsMultivariable analysisCervical dilationLower riskSecondary analysisHealth Resource Utilization of Labor Induction Versus Expectant Management
Grobman W, Sandoval G, Reddy U, Tita A, Silver R, Mallett G, Hill K, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Iams J, Chien E, Casey B, Gibbs R, Srinivas S, Swamy G, Simhan H, Macones G. Health Resource Utilization of Labor Induction Versus Expectant Management. Obstetric Anesthesia Digest 2021, 41: 34-34. DOI: 10.1097/01.aoa.0000732480.32100.cf.Peer-Reviewed Original ResearchExpectant managementElective inductionNulliparous womenLow-risk nulliparous womenHealth care resource utilizationHealth resource utilizationNeonatal respiratory morbidityElective labor inductionARRIVE trialDelivery admissionHypertensive disordersCesarean deliveryLabor inductionRespiratory morbidityWeeks postpartumTrialsManagement trialsWeeksWomenInductionCurrent studyResource utilizationAntepartumMorbidityPregnancy
2018
Defining Failed Induction of Labor
Grobman W, Bailit J, Lai Y, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Defining Failed Induction of Labor. Obstetric Anesthesia Digest 2018, 38: 215. DOI: 10.1097/01.aoa.0000547313.79293.f8.Peer-Reviewed Original ResearchNonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery
Kawakita T, Iqbal S, Huang C, Reddy U. Nonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery. Obstetric Anesthesia Digest 2018, 38: 125-126. DOI: 10.1097/01.aoa.0000542343.43890.b0.Peer-Reviewed Original ResearchInduction of laborMorbidly obese womenCesarean deliveryObese womenExpectant managementClass III obesityRetrospective cohort studyNormal-weight womenIndicated inductionMaternal comorbiditiesMorbid obesityNeonatal outcomesCohort studySecondary outcomesWeeks' gestationRisk factorsHigh prevalenceClass IIObesityWomenComorbiditiesInductionOutcomesDeliveryRiskReassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz KL, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman MK, Reddy UM. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetrics And Gynecology 2018, 131: 345-353. PMID: 29324600, PMCID: PMC5785437, DOI: 10.1097/aog.0000000000002431.Peer-Reviewed Original ResearchConceptsSpontaneous vaginal birthSecond stage durationVaginal birthNulliparous womenNeonatal complicationsNeonatal morbidityCesarean deliveryFetal heart rate tracingsFirst half hourPrior cesarean deliverySpontaneous vaginal deliveryWeeks of gestationHeart rate tracingsVertex birthsRetrospective cohortMultiparous womenSerious complicationsSerious morbidityVaginal deliveryMorbidityHalf hourLikelihood of birthComplicationsWomenBirth
2017
Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface
Bukowski R, Sadovsky Y, Goodarzi H, Zhang H, Biggio JR, Varner M, Parry S, Xiao F, Esplin SM, Andrews W, Saade GR, Ilekis JV, Reddy UM, Baldwin DA. Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. PeerJ 2017, 5: e3685. PMID: 28879060, PMCID: PMC5582610, DOI: 10.7717/peerj.3685.Peer-Reviewed Original ResearchMaternal-fetal interfacePreterm birthTerm birthsFetal interfaceDownregulation of chemokinesAbsence of laborBurden of diseasePremature deliveryCesarean deliveryOverall mortalityChemokine expressionTerm laborNeonatal mortalityPregnant womenUterine fundusTerm parturitionHuman pretermPlacental functionMaternal bloodMultiple pathwaysFetal bloodPretermExpression profilesImmune rejectionImmune systemMaternal and Neonatal Outcomes With Early Compared With Delayed Pushing Among Nulliparous Women
Yee L, Sandoval G, Bailit J, Reddy U, Wapner R, Varner M, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Maternal and Neonatal Outcomes With Early Compared With Delayed Pushing Among Nulliparous Women. Obstetric Anesthesia Digest 2017, 37: 98-99. DOI: 10.1097/01.aoa.0000515771.11264.4b.Peer-Reviewed Original ResearchNeonatal Outcomes by Attempted Mode of Delivery and Obstetric Intervention for Pregnancies Affected by Spina Bifida [19R]
Spiliopoulos M, Iqbal S, Reddy U, Landy H, Huang C. Neonatal Outcomes by Attempted Mode of Delivery and Obstetric Intervention for Pregnancies Affected by Spina Bifida [19R]. Obstetrics And Gynecology 2017, 129: 188s. DOI: 10.1097/01.aog.0000514163.09127.5e.Peer-Reviewed Original ResearchImmediate neonatal outcomeNeonatal outcomesCesarean deliveryMode of deliveryVaginal deliverySpina bifidaInduced laborLabor induction groupRetrospective cohort studyPrevious cesarean deliveryInduction of laborMultivariable logistic regressionWeeks of gestationYears of ageSafe Labor studyNICU admissionCesarean sectionCohort studyRespiratory morbiditySingleton pregnanciesSpontaneous laborBreech deliveryGestational ageObstetric interventionsBirth trauma