2024
Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy
Greenland P, Segal M, McNeil R, Parker C, Pemberton V, Grobman W, Silver R, Simhan H, Saade G, Ganz P, Mehta P, Catov J, Merz C, Varagic J, Khan S, Parry S, Reddy U, Mercer B, Wapner R, Haas D. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy. JAMA Cardiology 2024, 9: 791-799. PMID: 38958943, PMCID: PMC11223045, DOI: 10.1001/jamacardio.2024.1621.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveCase-control studyHypertensive disordersEarly pregnancyClinical dataSmall-for-gestational-age infantsPrediction of hypertensive disordersSmall-for-gestational-ageHypertensive disorders of pregnancyPrediction of HDPDisorders of pregnancyNested case-control studyPlasma samplesMulticenter observational studyStored plasma samplesReceiver operating characteristic curveBody mass indexGestational hypertensionNon-Hispanic blacksPreterm birthFetal sexFirst-trimesterNon-Hispanic whitesPregnancy outcomesMaternal race
2023
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. JAMA 2023, 330: 2191-2199. PMID: 38085313, PMCID: PMC10716715, DOI: 10.1001/jama.2023.21146.Peer-Reviewed Original ResearchConceptsPrimary composite outcomeAdverse pregnancy outcomesComposite outcomeFirst trimesterCannabis exposurePregnancy outcomesCannabis usePlacental functionPropensity score-weighted analysisNulliparous Pregnancy Outcomes StudyOngoing exposureMaternal cannabis useUrine cotinine assayUrine samplesMedical record abstractionPregnancy outcome dataGestational-age birthsBody mass indexGestational age windowsPregnancy Outcomes StudyUS medical centersOngoing cannabis useAdjudication of outcomesMaternal cannabisHypertensive disordersAssociation between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals
Delgado A, Kendle A, Randis T, Donda K, Salemi J, Facco F, Parker C, Reddy U, Silver R, Basner R, Chung J, Schubert F, Pien G, Redline S, Parry S, Grobman W, Zee P, Louis J. Association between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals. American Journal Of Perinatology 2023, 41: e2418-e2426. PMID: 37380034, DOI: 10.1055/a-2115-0147.Peer-Reviewed Original ResearchSleep-disordered breathingAdverse neonatal outcomesNeonatal outcomesPrimary outcomeRisk ratioApnea-hypopnea indexRespiratory distress syndromeBody mass indexEvents/hConfidence intervalsSleep Disordered BreathingLog-binomial regressionNulliparous individualsHome sleep studiesChronic hypertensionNeonatal morbidityNew onsetPregestational diabetesComposite outcomeRespiratory supportTransient tachypneaDistress syndromeGestational ageMass indexMaternal riskAssociation of maternal body mass index with success and outcomes of attempted operative vaginal delivery
Grasch J, Venkatesh K, Grobman W, Silver R, Saade G, Mercer B, Yee L, Scifres C, Parry S, Simhan H, Reddy U, Frey H. Association of maternal body mass index with success and outcomes of attempted operative vaginal delivery. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101081. PMID: 37422004, DOI: 10.1016/j.ajogmf.2023.101081.Peer-Reviewed Original ResearchConceptsMaternal body mass indexBody mass indexOperative vaginal deliveryVaginal delivery attemptComposite maternal morbidityComposite neonatal morbidityVaginal deliveryMass indexNeonatal morbidityCesarean deliveryMaternal morbidityAdverse outcomesSecond-stage cesarean deliveryBody mass index groupsBody mass index categoriesNulliparous Pregnancy Outcomes StudyNonanomalous singleton pregnanciesNeonatal adverse outcomesMultivariable logistic regressionPregnancy Outcomes StudyNulliparous individualsDose-dependent mannerSecondary outcomesSingleton pregnanciesPrimary outcomeHypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers
Battarbee A, Mele L, Landon M, Varner M, Casey B, Reddy U, Wapner R, Rouse D, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S. Hypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers. American Journal Of Perinatology 2023, 41: e1976-e1981. PMID: 37201538, PMCID: PMC10755076, DOI: 10.1055/a-2096-0443.Peer-Reviewed Original ResearchBaseline body mass indexHypertensive disordersGestational hypertensionCardiovascular biomarkersHigher baseline blood pressureLow GDF-15 levelsAssociation of HDPPresence of HDPGDF-15 levelsBaseline blood pressureHomeostatic model assessmentBody mass indexStudy of patientsSerum insulin concentrationsLongitudinal studyMultivariable linear regressionChronic hypertensionGDM cohortPregnancy hypertensionGDF-15Insulinogenic indexPostpartum interventionsBlood pressureMass indexCardiovascular dysfunctionMaternal Morbidity Risk Factors in Nulliparas
Merriam A, Metz T, Allshouse A, Silver R, Haas D, Grobman W, Simhan H, Wapner R, Wing D, Mercer B, Parry S, Reddy U, Investigators +. Maternal Morbidity Risk Factors in Nulliparas. American Journal Of Perinatology 2023, 41: e1878-e1884. PMID: 37150178, DOI: 10.1055/a-2088-2586.Peer-Reviewed Original ResearchVenous thromboembolic eventsSelf-identified black raceComposite maternal morbidityPrimary maternal outcomeSevere maternal morbidityMaternal morbidityChronic kidney diseaseBlack raceRisk factorsChronic hypertensionHypertensive disordersMaternal outcomesPregestational diabetesKidney diseaseMedical conditionsMulticenter prospective observational cohortPrepregnancy body mass indexPreexisting medical comorbiditiesPrior obstetric historyProspective observational cohortMorbidity risk factorsBody mass indexMultiple risk factorsDays of deliveryLog-binomial regressionMaternal and Delivery Characteristics and Self-Reported Perceived Control During Labor
Mallett G, Hill K, Doherty L, Grobman W, Reddy U, Tita A, Silver R, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H, Macones G. Maternal and Delivery Characteristics and Self-Reported Perceived Control During Labor. Obstetrics And Gynecology 2023, 142: 117-124. PMID: 37290106, PMCID: PMC10330140, DOI: 10.1097/aog.0000000000005230.Peer-Reviewed Original ResearchConceptsBody mass indexWeeks of gestationLabor Agentry ScaleScale scoreLabor painPrivate health insuranceDelivery characteristicsLabor pain scoresPrevious pregnancy lossSpontaneous vaginal deliverySevere neonatal complicationsHealth insuranceMode of deliveryFinal multivariable modelMultivariable linear regressionSelf-administered questionnaireSelf-reported raceNeonatal complicationsExpectant managementPain scoresLabor inductionNonprivate insuranceOperative deliveryCesarean deliveryVaginal deliveryThe Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes
Costantine M, Tita A, Mele L, Casey B, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Rouse D, Sibai B, Mercer B, Caritis S, Bethesda F. The Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes. American Journal Of Perinatology 2023, 41: e1313-e1323. PMID: 36791785, PMCID: PMC10425571, DOI: 10.1055/s-0043-1761920.Peer-Reviewed Original ResearchYears of ageChild intelligence quotientSecondary outcomesBirth weightHead circumferenceNeurodevelopmental outcomesPrimary outcomeGestational ageHypothyroid disordersPopulation nomogramsGestational age birth weightIntelligence quotientHigher body mass indexLGA birth weightSGA birth weightInfant birth weightAdverse neurodevelopmental outcomesBody mass indexLarger head circumferenceFetal growth standardsOdds of childrenDetection of newbornsFetal Growth StudiesAGA neonatesSGA neonatesShort-term neonatal outcomes of pregnancies complicated by maternal obesity
Dinsmoor M, Ugwu L, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Short-term neonatal outcomes of pregnancies complicated by maternal obesity. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100874. PMID: 36690180, PMCID: PMC10065915, DOI: 10.1016/j.ajogmf.2023.100874.Peer-Reviewed Original ResearchConceptsComposite neonatal morbidityNeonatal outcomesBody mass indexWeeks of gestationMaternal obesityNeonatal morbidityMorbid obesityMass indexReference groupIntraventricular hemorrhage grade 3Short-term neonatal outcomesCohort of deliveriesComposite neonatal outcomeSuper morbid obesityHypoxic-ischemic encephalopathyPrevious cesarean deliveryRespiratory distress syndromeChronic hypertensionPreterm deliveryBaseline characteristicsCesarean deliveryComposite outcomeMaternal heightMaternal preeclampsiaObese patients
2022
Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women
Makarem N, Chau K, Miller E, Gyamfi-Bannerman C, Tous I, Booker W, Catov J, Haas D, Grobman W, Levine L, McNeil R, Merz C, Reddy U, Wapner R, Wong M, Bello N. Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women. JAMA Network Open 2022, 5: e2248165. PMID: 36547978, PMCID: PMC9857221, DOI: 10.1001/jamanetworkopen.2022.48165.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesMediterranean diet patternTime of conceptionPregnancy outcomesDiet patternLower oddsAMED scoresGestational diabetesCohort studyUS womenLower riskRisk of APOsPrepregnancy body mass indexCardiovascular disease risk factorsSemiquantitative food frequency questionnaireAlternate Mediterranean diet scoreNulliparous Pregnancy Outcomes StudyLowest AMED scoresGestational age infantsDisease risk factorsDose-response associationFood frequency questionnaireMediterranean diet scoreBody mass indexCause of morbidity
2019
Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes
Casey B, Rice M, Landon M, Varner M, Reddy U, Wapner R, Rouse D, Biggio J, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S, Van Dorsten J. Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes. American Journal Of Perinatology 2019, 37: 475-482. PMID: 30866027, PMCID: PMC6744360, DOI: 10.1055/s-0039-1681058.Peer-Reviewed Original ResearchConceptsMild gestational diabetes mellitusGestational diabetes mellitusBody mass indexMetabolic syndromeIndex pregnancyTreatment of womenSubsequent diabetesLong-term maternal outcomesMaternal body mass indexOral glucose tolerance testMild gestational diabetesFrequency of diabetesHomeostasis model assessmentGlucose tolerance testRisk of diabetesTreatment of diabetesEffect of treatmentRace/ethnicityGestational diabetesLipid panelMaternal outcomesBlood pressureDiabetes mellitusMedical therapyNutritional counseling
2018
Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network
Harrison MS, Thorsten VR, Dudley DJ, Parker CB, Koch MA, Hogue CJR, Stoll BJ, Silver RM, Varner MW, Pinar MH, Coustan DR, Saade GR, Bukowski RK, Conway DL, Willinger M, Reddy UM, Goldenberg RL. Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network. American Journal Of Perinatology 2018, 35: 1071-1078. PMID: 29609190, PMCID: PMC6436964, DOI: 10.1055/s-0038-1639340.Peer-Reviewed Original ResearchConceptsWhite blood cell countElevated white blood cell countBody mass indexBlood cell countSerum ferritin levelsC-reactive protein levelsNormal body mass indexMaternal serum ferritinInflammatory markersNormal-weight womenHistologic chorioamnionitisC-reactive proteinSerum ferritinLive birthsFerritin levelsCell countLogistic regression modelsWeight womenBMI categoriesCategories of BMIMaternal serum ferritin levelsStillbirth Collaborative Research NetworkPrepregnancy body mass indexElevated body mass indexLogistic regression
2011
Prepregnancy Risk Factors for Antepartum Stillbirth in the United States
Reddy U, Laughon S, Sun L, Troendle J, Willinger M, Zhang J. Prepregnancy Risk Factors for Antepartum Stillbirth in the United States. Obstetrical & Gynecological Survey 2011, 66: 69-70. DOI: 10.1097/ogx.0b013e31821686c6.Peer-Reviewed Original ResearchPrepregnancy risk factorsAntepartum stillbirthBody mass indexRisk factorsAdvanced maternal ageChronic hypertensionTerm stillbirthMaternal ageMass indexPrepregnancy body mass indexLive birth controlsRisk of stillbirthWeeks of gestationAfrican American racePotential risk factorsIndividual risk factorsYears of ageAdjusted riskAntenatal surveillanceCesarean deliveryPreterm birthSingleton pregnanciesPreexisting diabetesTerm deliveryNormal weight