2016
Potassium Channelopathies and Gastrointestinal Ulceration
Han J, Lee SH, Giebisch G, Wang T. Potassium Channelopathies and Gastrointestinal Ulceration. Gut And Liver 2016, 10: 881-889. PMID: 27784845, PMCID: PMC5087926, DOI: 10.5009/gnl15414.Peer-Reviewed Original ResearchConceptsPotassium channelsGI tractPotassium channelopathiesAdenosine triphosphate-sensitive potassium channel openerTriphosphate-sensitive potassium channel openerNonsteroidal anti-inflammatory drugsAntianginal drug nicorandilAnti-inflammatory drugsPotassium channel openersOccurrence of ulcerationPotassium channel activityLong-term useRegulation of secretionGastrointestinal ulcerationUlcerative colitisPeptic ulcerationChannel openersGastric acidGastrointestinal tractUlcerationDifferent biological actionsTransporter inhibitorsAnal regionPotassium homeostasisTract
2013
Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
Li H, Du Z, Barone S, Rubera I, McDonough A, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. Journal Of Molecular Medicine 2013, 91: 951-963. PMID: 23508938, PMCID: PMC3730089, DOI: 10.1007/s00109-013-1015-3.Peer-Reviewed Original ResearchConceptsNa+/H+ exchanger NHE3Proximal convoluted tubulesKO miceMetabolic acidosisBicarbonate reabsorptionDays of acid loadingIsolated proximal convoluted tubulesConvoluted tubulesIn vitro microperfusion studyCompared to WT miceNHE3 knockout miceProximal tubule NHE3Acid loadNH4Cl acid loadMild metabolic acidosisWT miceNHE3Microperfusion studiesKnockout miceBicarbonate absorptionMutant miceVolume reabsorptionFloxed miceNH4Cl loadingTransgenic mice
2003
Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium
Coric T, Hernandez N, de la Rosa D, Shao D, Wang T, Canessa CM. Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium. AJP Gastrointestinal And Liver Physiology 2003, 286: g663-g670. PMID: 14630642, DOI: 10.1152/ajpgi.00364.2003.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAnimalsAntibodies, BlockingAntibody SpecificityBlotting, NorthernCHO CellsColonCricetinaeDNA, ComplementaryEnzyme InductionEpithelial Sodium ChannelsEpitheliumFluorescent Antibody TechniqueImmediate-Early ProteinsIntestinal MucosaNuclear ProteinsPlasmidsProtein Serine-Threonine KinasesRatsRNA, MessengerSignal TransductionSodium ChannelsConceptsDistal colonGlucocorticoid-induced kinase 1Intestinal epitheliumConcentrations of aldosteroneSubunits of ENaCSodium channel activityExpression of ENaCRat intestinal epitheliumKinase 1Aldosterone levelsAldosterone-dependent mannerSingle doseSodium depletionChronic increaseDistal tubulesControl animalsAldosteroneAldosterone inductionRat intestineBasal conditionsColonSodium transportersEpitheliumSites of expressionSGK1