2012
Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase α1-deficient mice
Buys E, Raher M, Kirby A, Mohd S, Baron D, Hayton S, Tainsh L, Sips P, Rauwerdink K, Tainsh R, Shakartzi H, Stevens C, Decaluwé K, da Gloria Rodrigues-Machado M, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly M, Bloch K. Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase α1-deficient mice. Nitric Oxide 2012, 27: s25-s26. DOI: 10.1016/j.niox.2012.04.093.Peer-Reviewed Original ResearchRenin-angiotensin-aldosterone systemQuantitative trait lociRenin-angiotensin-aldosterone system signalingPlasma angiotensin II levelsEtiology of human hypertensionPlasma aldosterone levelsGlomerular filtration rateNitric oxideNO-cGMP signalingAngiotensin II levelsEndothelium-dependent vasorelaxationImpaired NO-cGMP signalingBlood urea nitrogenSubunit of soluble guanylate cyclaseAssociated with increased activitySoluble guanylate cyclaseImproving endothelium-dependent vasorelaxationRegulating blood pressureAldosterone levelsB6 miceMale F2 offspringNO-cGMPRenal functionUrinary volumeEssential hypertensionEffect of Acute Infusion of Low‐Molecular‐Weight Polyvinylpyrrolidone on Renal Function
Yan Q, Du Z, Wan L, Beck F, Giebisch G, Wang T. Effect of Acute Infusion of Low‐Molecular‐Weight Polyvinylpyrrolidone on Renal Function. The FASEB Journal 2012, 26: 1100.2-1100.2. DOI: 10.1096/fasebj.26.1_supplement.1100.2.Peer-Reviewed Original ResearchBlood urea nitrogenGlomerular filtration rateNatriuretic effectRenal functionEffects of acute i.Reduced glomerular filtration rateProximal tubular absorptionLong-term administrationAlpha-1-microglobulin excretionPVP storage diseaseAlpha 1-microglobulinKaliuretic effectAcute i.Renal failureUrine volumeRenal injuryProximal tubulesFiltration rateRenal damageNephron segmentsMonocyte/macrophage systemInfusionClearance experimentsUrea nitrogenNa+ loss
2011
Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction
Wang T. Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction. Clinical And Experimental Nephrology 2011, 16: 49-54. PMID: 22038261, DOI: 10.1007/s10157-011-0495-0.Peer-Reviewed Original ResearchConceptsThick ascending limbIon transporter expressionRenal outer medullary potassium channelBartter's syndromeInward rectifier potassium channelPotassium channelsSmall-conductance K channelsROMK null miceMedullary thick ascending limbType II Bartter's syndromeSimilar phenotypeMammalian kidneyApical membraneK channelsROMK knockout miceKnockout modelsChannel activityChannel mutationsRenal functionLimb functionNull micePhysiological conditionsSalt wastingTransporter expressionPathophysiological conditionsGENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE
Yan Q, Wan L, Du Z, Gotoh N, Wang T. GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE. The FASEB Journal 2011, 25: 835.9-835.9. DOI: 10.1096/fasebj.25.1_supplement.835.9.Peer-Reviewed Original ResearchGlomerular filtration rateAT2 receptorsUrine volumeProximal tubulesNull miceAngiotensin II type 2 receptorAT1a-/- miceMale null miceType 2 receptorExpression levelsAT1A+/+ miceAT2 inhibitorENaC expressionAT2 expressionKidneys of maleNatriuretic effectWT miceNa+ excretionRenal functionNa+ absorptionReal-time PCRFemale null micePD123319Renal clearanceFiltration rate
2008
Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo
Wei F, Karihaloo A, Yu Z, Marlier A, Seth P, Shibazaki S, Wang T, Sukhatme VP, Somlo S, Cantley LG. Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo. Kidney International 2008, 74: 1310-1318. PMID: 18974761, PMCID: PMC3793389, DOI: 10.1038/ki.2008.395.Peer-Reviewed Original ResearchConceptsNeutrophil Gelatinase-Associated LipocalinCyst growthGelatinase-associated lipocalinAutosomal dominant polycystic kidney diseaseTubular cell proliferationDominant polycystic kidney diseaseCell linesPolycystic kidney diseasePkd1 mutant miceRenal functionAdenoviral delivery systemAssociated lipocalinKidney diseaseRate of proliferationCyst enlargementProliferative responseRenal epithelial cellsProximal tubulesMutant miceEpithelial cellsFlow stimuliCell proliferationDecreased rateApical ciliaProliferationFemale ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production
Yan Q, Yang X, Cantone A, Giebisch G, Hebert S, Wang T. Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. AJP Regulatory Integrative And Comparative Physiology 2008, 295: r997-r1004. PMID: 18579648, PMCID: PMC2536865, DOI: 10.1152/ajpregu.00051.2007.Peer-Reviewed Original ResearchConceptsROMK null miceFemale null miceNull miceRenal functionSurvival rateExtent of hydronephrosisDegree of hydronephrosisSeverity of hydronephrosisHigher PGE2 productionHydronephrotic miceLower GFRSyndrome pathophysiologyNg/24 hAcid-base parametersFemale micePGE2 productionHydronephrosisHigher survival rateMiceExcretionSignificant differencesUrinaryMalesSexPossible mechanismBLOOD PRESSURE AND RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE
Yan Q, Raksaseri P, Weldon S, Kabcenell A, Hebert S, Wang T. BLOOD PRESSURE AND RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE. The FASEB Journal 2008, 22: 479.34-479.34. DOI: 10.1096/fasebj.22.1_supplement.479.34.Peer-Reviewed Original Research
2007
Transgenic RNAi Depletion of Claudin-16 and the Renal Handling of Magnesium*
Hou J, Shan Q, Wang T, Gomes A, Yan Q, Paul D, Bleich M, Goodenough D. Transgenic RNAi Depletion of Claudin-16 and the Renal Handling of Magnesium*. Journal Of Biological Chemistry 2007, 282: 17114-17122. PMID: 17442678, DOI: 10.1074/jbc.m700632200.Peer-Reviewed Original ResearchConceptsClaudin-16Tight junction proteinsTight junction proteins claudin-16Junction proteinsRenal handlingTight junctionsRenal handling of magnesiumRenal wasting of magnesiumParacellular ion reabsorptionHandling of magnesiumKnock-downFamilial hypomagnesemiaRenal functionElectrolyte disordersCation channelsTarget of drug developmentAscending limbMouse modelFHHNCParacellular cation channelsControl of ion homeostasisRenal controlIn vivo analysisIon reabsorptionNephrocalcinosisFunctional Expression of Key Components of the Olfactory Receptor Signaling Pathway in the Distal Nephron
Pluznick J, Zhang X, Zou D, Yan Q, Wells E, Wang T, Firestein S, Caplan M. Functional Expression of Key Components of the Olfactory Receptor Signaling Pathway in the Distal Nephron. The FASEB Journal 2007, 21: a500-a500. DOI: 10.1096/fasebj.21.5.a500.Peer-Reviewed Original ResearchGlomerular filtration rateMouse kidneyRenal function studiesMacula densa cellsWild-type littermatesNormal mouse kidneyOlfactory G-proteinOlfactory receptorsReceptor Signaling PathwayRenal functionFiltration rateDistal tubulesDistal nephronKidneyWestern blotTubule segmentsRT-PCRAdenylyl cyclaseMiceNon-olfactory tissuesPotential roleG proteinsSignaling pathwaysFunction studiesMD cells
1990
Cholinergic effect on rat proximal convoluted tubule
Wang T, Chan Y. Cholinergic effect on rat proximal convoluted tubule. Pflügers Archiv - European Journal Of Physiology 1990, 415: 533-539. PMID: 2109302, DOI: 10.1007/bf02583503.Peer-Reviewed Original ResearchConceptsPCT transportProximal convoluted tubulesA-23187Cholinergic receptorsHigher doses of carbacholInhibitory effect of carbacholRate of bicarbonate absorptionConvoluted tubulesCholinergic effectsRegulation of renal functionRat proximal convoluted tubuleEffects of cholinergic agentsEffect of carbacholAddition of carbacholDose of carbacholFunctional cholinergic receptorsCarbachol-induced effectsProximal tubular absorptionIonophore A-23187Bicarbonate-Ringer solutionInhibitory effectNo effectRenal functionBasolateral sideCalcium influx