2017
Urinary bladder hypertrophy characteristic of male ROMK Bartter’s mice does not occur in female mice
Kim JM, Xu S, Guo X, Hu H, Dong K, Wang T. Urinary bladder hypertrophy characteristic of male ROMK Bartter’s mice does not occur in female mice. AJP Regulatory Integrative And Comparative Physiology 2017, 314: r334-r341. PMID: 29092859, PMCID: PMC5899254, DOI: 10.1152/ajpregu.00315.2017.Peer-Reviewed Original ResearchConceptsKO miceBladder hypertrophyBladder weightUrinary bladder hypertrophyRenal outer medullary potassium channelSeverity of hydronephrosisWild-type miceROMK knockout miceBladder capacityDetrusor muscleWT miceUrinary tractBartter's syndromeFemale miceSalt wastingHydronephrosisKnockout miceROMK expressionMiceBladderHypertrophyPotassium channelsMRNA levelsSignificant enlargementSyndrome
2016
Hydronephrosis and Urinary Bladder Hypertrophy in ROMK Bartter's Mouse
Kim J, Guo X, Hu H, Xu S, Wang T. Hydronephrosis and Urinary Bladder Hypertrophy in ROMK Bartter's Mouse. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1224.30.Peer-Reviewed Original ResearchThickness of urotheliumKO miceROMK expressionBladder capacityBladder weightWT miceKnockout miceRenal outer medullary potassium channelLuminal membraneROMK knockout miceUrinary bladder hypertrophyLow K intakeWestern blottingLow potassium dietSmooth muscle layerMonths of ageNormal KBladder hypertrophyDetrusor muscleMouse bladderBartter's syndromePotassium dietK intakeROMKUrinary bladderExpression of KCNJ1 (ROMK) in the Gastrointestinal Tract
Han J, Lee S, Ishikawa Y, Guo X, Xu S, Wang T. Expression of KCNJ1 (ROMK) in the Gastrointestinal Tract. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1224.31.Peer-Reviewed Original ResearchROMK expressionDistal colonMRNA expressionKO miceRenal outer medullary potassium channelEpithelial cellsGI tractGastric acid secretionGastrointestinal (GI) tractHK intakeROMK channelsWT miceDistal nephronReal-time PCRApical membraneROMKPotassium channelsAcid secretionParietal cellsIF stainingRenal tubulesQ-PCR dataEsophagusDiet animalsGastrointestinal tract
2011
Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium
Wade JB, Fang L, Coleman RA, Liu J, Grimm PR, Wang T, Welling PA. Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium. American Journal Of Physiology. Renal Physiology 2011, 300: f1385-f1393. PMID: 21454252, PMCID: PMC3119145, DOI: 10.1152/ajprenal.00592.2010.Peer-Reviewed Original ResearchConceptsDistal nephronDistal nephron segmentsRenal K secretionROMK knockout miceDietary potassiumExtent of expressionKnockout miceK secretionROMK expressionNephron segmentsNew antibodiesApical labelingPhysiological stimuliNephronROMKAntibodiesROMK channelsApical expressionChannel localizationChannel functionDifferential regulationLarge increaseDCT2Different regulatory mechanismsExtensive pattern