2019
Sustained‐release of hydrogen sulfide by GYY4137 protected diabetic‐induced kidney injury
Yu Y, Xu S, Ji D, Wang X, Wang T. Sustained‐release of hydrogen sulfide by GYY4137 protected diabetic‐induced kidney injury. The FASEB Journal 2019, 33: 567.2-567.2. DOI: 10.1096/fasebj.2019.33.1_supplement.567.2.Peer-Reviewed Original ResearchDKD miceDiabetic kidney diseaseWestern blottingLevels of apoptosisUntreated groupSustained-releaseUrine albuminTUNEL stainingSignaling moleculesPodocyte foot processesDiabetic kidney disease patientsAdministration of GYY4137Urinary albumin concentrationGaseous signaling moleculeProtective effectApoptosisCD-1 miceExpression of CBSBeta-lyaseExpression levelsFASEB JournalFoot processesHigh-fat dietFusion of foot processesMouse kidney
2015
Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression
Guo X, Li Z, Zhang C, Yi Z, Li H, Cao L, Yuan C, Hong W, Wu Z, Peng D, Chen J, Xia W, Zhao G, Wang F, Yu S, Cui D, Xu Y, Golam CM, Smith AK, Wang T, Fang Y. Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression. Journal Of Psychiatric Research 2015, 69: 1-6. PMID: 26343587, DOI: 10.1016/j.jpsychires.2015.07.011.Peer-Reviewed Original ResearchConceptsSubsyndromal symptomatic depressionPeripheral blood mononuclear cellsHan Chinese patientsSSD patientsMRNA expression levelsMDD patientsSymptomatic depressionChinese patientsBlood mononuclear cellsSingle nucleotide polymorphismsExpression levelsMononuclear cellsPatientsMRNA expressionCommon diseaseReal-time quantitative PCR studiesSignificant decreaseSignificant social dysfunctionSocial dysfunctionPCR studiesCandidate genesTranscript networksFunctional annotation toolMultiple single nucleotide polymorphismsQuantitative PCR studies
2011
GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE
Yan Q, Wan L, Du Z, Gotoh N, Wang T. GENDER DIFFERENCE IN MODULATION OF ANGIOTENSIN II TYPE 2 RECEPTOR (AT2) FUNCTION AND EXPRESSION IN AT1A RECEPTOR‐DEFICIENT MICE. The FASEB Journal 2011, 25: 835.9-835.9. DOI: 10.1096/fasebj.25.1_supplement.835.9.Peer-Reviewed Original ResearchGlomerular filtration rateAT2 receptorsUrine volumeProximal tubulesNull miceAngiotensin II type 2 receptorAT1a-/- miceMale null miceType 2 receptorExpression levelsAT1A+/+ miceAT2 inhibitorENaC expressionAT2 expressionKidneys of maleNatriuretic effectWT miceNa+ excretionRenal functionNa+ absorptionReal-time PCRFemale null micePD123319Renal clearanceFiltration rate