2020
Distributed Patterns of Functional Connectivity Predict Working Memory Performance in Novel Healthy and Memory-impaired Individuals
Avery EW, Yoo K, Rosenberg MD, Greene AS, Gao S, Na DL, Scheinost D, Constable TR, Chun MM. Distributed Patterns of Functional Connectivity Predict Working Memory Performance in Novel Healthy and Memory-impaired Individuals. Journal Of Cognitive Neuroscience 2020, 32: 241-255. PMID: 31659926, PMCID: PMC8004893, DOI: 10.1162/jocn_a_01487.Peer-Reviewed Original ResearchConceptsFunctional connectivity patternsFluid intelligenceMemory performanceIndividual differencesAttention modelConnectome-based predictive modelingConnectome-based predictive modelsWhole-brain functional connectivity patternsGeneral cognitive abilitySuch individual differencesConnectivity patternsAdult life spanHuman Connectome ProjectHuman Connectome Project dataMemory relateCognitive abilitiesNeural basisSustained attentionMemory scoresParietal regionsFunctional connectivityConnectome ProjectMemory modelOlder adultsMemory
2019
The individual functional connectome is unique and stable over months to years
Horien C, Shen X, Scheinost D, Constable RT. The individual functional connectome is unique and stable over months to years. NeuroImage 2019, 189: 676-687. PMID: 30721751, PMCID: PMC6422733, DOI: 10.1016/j.neuroimage.2019.02.002.Peer-Reviewed Original ResearchConceptsHigh ID ratesIndividual differencesFunctional connectomeIndividual functional connectomesStable individual differencesID rateResting-state fMRI datasetsFrontoparietal networkFunctional connectivityParietal cortexFMRI datasetsIdiosyncratic aspectsConnectomeHead motionEntire brainFMRIBrainCortexSpecific datasetDifferencesConnectivityMultisite reliability and repeatability of an advanced brain MRI protocol
Schwartz DL, Tagge I, Powers K, Ahn S, Bakshi R, Calabresi PA, Constable R, Grinstead J, Henry RG, Nair G, Papinutto N, Pelletier D, Shinohara R, Oh J, Reich DS, Sicotte NL, Rooney WD, Cooperative O. Multisite reliability and repeatability of an advanced brain MRI protocol. Journal Of Magnetic Resonance Imaging 2019, 50: 878-888. PMID: 30652391, PMCID: PMC6636359, DOI: 10.1002/jmri.26652.Peer-Reviewed Original Research
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
2009
Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging
Hirshberg B, Qiu M, Cali AM, Sherwin R, Constable T, Calle RA, Tal MG. Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging. Diabetologia 2009, 52: 1561. PMID: 19488737, DOI: 10.1007/s00125-009-1406-8.Peer-Reviewed Original ResearchConceptsType 1 diabetic patientsPancreatic blood flowDiabetic patientsBlood flowIslet massHealthy volunteersPancreatic perfusionArterial spin labeling magnetic resonanceTotal pancreatic blood flowPancreatic beta-cell massConclusions/interpretationOur dataAims/hypothesisLossBeta-cell massMagnetic resonance perfusionSignificant differencesHuman pancreatic isletsDiabetes mellitusVascularised organsIslet functionMurine modelClamp studiesNormal volunteersHealthy individualsPatientsControl tissuesLanguage lateralization in epilepsy patients: fMRI validated with the Wada procedure
Arora J, Pugh K, Westerveld M, Spencer S, Spencer DD, Constable R. Language lateralization in epilepsy patients: fMRI validated with the Wada procedure. Epilepsia 2009, 50: 2225-2241. PMID: 19490042, DOI: 10.1111/j.1528-1167.2009.02136.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVerbal fluency taskWada procedureSentence comprehensionFluency taskLaterality scoresLanguage lateralizationLaterality indexAuditory sentence comprehensionFMRI language mappingAuditory taskReading taskConjunction analysisHemispheric dominanceLateralization scoresFMRI laterality indicesLanguage mappingWada testingMidline regionWada testLateralizationSpecific patient examplesQuantifying activationTaskComprehension
2006
Brain Connectivity Related to Working Memory Performance
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingFemaleHumansMaleMemoryMiddle AgedNerve NetPsychomotor PerformanceConceptsPosterior cingulate cortexMemory taskCognitive tasksCingulate cortexVentral anterior cingulate cortexDifferent cognitive tasksMedial frontal regionsMedial frontal gyrusDefault mode networkAnterior cingulate cortexFunctional imaging studiesCognitive abilitiesIndividual differencesMemory performanceCognitive performanceFrontal gyrusMode networkFrontal regionsFunctional connectivityBrain connectivityBrain areasTaskFunctional connectionsImaging studiesCortex
2001
Functional MRI of Language Processing: Dependence on Input Modality and Temporal Lobe Epilepsy
Carpentier A, Pugh K, Westerveld M, Studholme C, Skrinjar O, Thompson J, Spencer D, Constable R. Functional MRI of Language Processing: Dependence on Input Modality and Temporal Lobe Epilepsy. Epilepsia 2001, 42: 1241-1254. PMID: 11737158, DOI: 10.1046/j.1528-1157.2001.35500.x.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAuditory language taskLanguage tasksLanguage processingTask presentationLateralization scoresLanguage comprehension taskVisual language taskModality-specific areasInput modalitiesDifferent input modalitiesMagnetic resonance imagingTemporal lobe epilepsy patientsFMRI resultsBA 44FMRI findingsAuditory inputBroca's areaLanguage areasNeuropsychological testingVisual inputFMRI dataWada testingLanguage localizationAbstract dimensionsPatterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Carpentier A, Constable R, Schlosser M, de Lotbinière A, Piepmeier J, Spencer D, Awad I. Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. Journal Of Neurosurgery 2001, 94: 946-54. PMID: 11409524, DOI: 10.3171/jns.2001.94.6.0946.Peer-Reviewed Original ResearchConceptsFMR imaging activationSurgical interventionRolandic regionMotor cortex plasticityMotor task paradigmFunctional magnetic resonance imagingMotor skillsMagnetic resonance imagingSevere motor impairmentFunctional magnetic resonanceFunctional recoveryLesion sideCortical abnormalitiesMotor cortexControl volunteersCortical malformationsStructural lesionsContralateral hemisphereArteriovenous malformationsBrain lesionsSurgical proceduresMotor impairmentPathological lesionsFunctional reorganizationAuthors' institution
2000
Network analysis of brain activations in working memory: Behavior and age relationships
Mencl W, Pugh K, Shaywitz S, Shaywitz B, Fulbright R, Constable R, Skudlarski P, Katz L, Marchione K, Lacadie C, Gore J. Network analysis of brain activations in working memory: Behavior and age relationships. Microscopy Research And Technique 2000, 51: 64-74. PMID: 11002354, DOI: 10.1002/1097-0029(20001001)51:1<64::aid-jemt7>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsMedial temporal lobeFunctional magnetic resonance imagingBrain activationTemporal lobeBetter memory performanceInferior frontal gyrusRight medial temporal lobeRight prefrontal regionsMedial frontal cortexInferior temporal lobeMemory recognitionMemory testMemory performanceInferior frontalPrefrontal regionsFrontal gyrusNew stimuliExtrastriate cortexRehearsal periodMemory impairmentBrain scoreOlder subjectsVisual formAge effectsRecognition periodThe Angular Gyrus in Developmental Dyslexia: Task-Specific Differences in Functional Connectivity Within Posterior Cortex
Pugh K, Mencl W, Shaywitz B, Shaywitz S, Fulbright R, Constable R, Skudlarski P, Marchione K, Jenner A, Fletcher J, Liberman A, Shankweiler D, Katz L, Lacadie C, Gore J. The Angular Gyrus in Developmental Dyslexia: Task-Specific Differences in Functional Connectivity Within Posterior Cortex. Psychological Science 2000, 11: 51-56. PMID: 11228843, DOI: 10.1111/1467-9280.00214.Peer-Reviewed Original ResearchConceptsDevelopmental dyslexiaAngular gyrusFunctional connectivityPhonological assemblyLeft hemispherePhonological processing domainTask-specific differencesLanguage-dominant left hemispherePosterior brain regionsTemporal lobe sitesDyslexic readersNeurobiological anomaliesPhonological performanceExplicit demandDyslexiaBrain regionsGyrusPosterior cortexTaskCompensatory roleVaried demandsPosterior regionDyslexicsConnectivityHemisphere
1995
Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization.
Puce A, Constable R, Luby M, McCarthy G, Nobre A, Spencer D, Gore J, Allison T. Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization. Journal Of Neurosurgery 1995, 83: 262-70. PMID: 7616272, DOI: 10.3171/jns.1995.83.2.0262.Peer-Reviewed Original ResearchConceptsSensorimotor cortexFunctional magnetic resonance imagingMagnetic resonance imagingFunctional MR imagingMotor cortexElectrical stimulationResonance imagingMR imagingUseful noninvasive methodSensory tasksRefractory seizuresMedian nerveAxial gradient echo imagesNormal subjectsSensorimotor areasElectrophysiological localizationFunctional assessmentPrimary sensoryCentral sulcusThenar regionCortexMotor tasksNoninvasive methodGradient-echo imagesPatients
1992
Multicoil high-resolution fast spin-echo MR imaging of the female pelvis.
Smith R, Reinhold C, McCauley T, Lange R, Constable R, Kier R, McCarthy S. Multicoil high-resolution fast spin-echo MR imaging of the female pelvis. Radiology 1992, 184: 671-5. PMID: 1324508, DOI: 10.1148/radiology.184.3.1324508.Peer-Reviewed Original Research