2000
Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors
Nicolson R, Lenane M, Singaracharlu S, Malaspina D, Giedd JN, Hamburger SD, Gochman P, Bedwell J, Thaker GK, Fernandez T, Wudarsky M, Hommer DW, Rapoport JL. Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors. American Journal Of Psychiatry 2000, 157: 794-800. PMID: 10784474, DOI: 10.1176/appi.ajp.157.5.794.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaRisk factorsSchizophrenia spectrum disordersObstetrical complicationsMotor abnormalitiesDevelopmental impairmentMore obstetrical complicationsSmooth pursuit eye movementsChildhood-onset casesPathophysiology of schizophreniaEye-tracking dysfunctionLanguage-related brain regionsFamilial loading scoresFamilial risk factorsSocial impairmentNeurodevelopmental impairmentPremorbid abnormalitiesSpectrum disorderFamilial loadingPatientsLanguage impairmentBrain regionsSchizophreniaImpairmentAbnormalities
1999
Clinical and Neurobiological Correlates of Cytogenetic Abnormalities in Childhood-Onset Schizophrenia
Nicolson R, Giedd JN, Lenane M, Hamburger S, Singaracharlu S, Bedwell J, Fernandez T, Thaker GK, Malaspina D, Rapoport JL. Clinical and Neurobiological Correlates of Cytogenetic Abnormalities in Childhood-Onset Schizophrenia. American Journal Of Psychiatry 1999, 156: 1575-1579. PMID: 10518169, DOI: 10.1176/ajp.156.10.1575.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetBrainBrief Psychiatric Rating ScaleCerebral VentriclesChildChromosome AberrationsChromosome DeletionDevelopmental DisabilitiesFamilyFemaleHippocampusHumansIntelligence TestsMagnetic Resonance ImagingMalePrevalencePsychiatric Status Rating ScalesRisk FactorsSchizophreniaSchizophrenic PsychologyConceptsChildhood-onset schizophreniaCytogenetic abnormalitiesCytogenetic anomaliesEye tracking dysfunctionSubgroup of patientsChromosome 22q11 deletionNeurobiological correlatesRisk factor measuresSchizophrenia spectrum disordersObstetric complicationsGroup of childrenEtiologic contributionPathophysiologic roleChildhood onsetFragile X testingLower performance IQPatientsGreater impairmentAbnormalitiesDevelopmental impairmentEarly onsetChromosomal abnormalitiesSchizophreniaEarly ageImpairment