2016
Assessing the utility of Xpert® MTB/RIF as a screening tool for patients admitted to medical wards in South Africa
Heidebrecht CL, Podewils LJ, Pym AS, Cohen T, Mthiyane T, Wilson D. Assessing the utility of Xpert® MTB/RIF as a screening tool for patients admitted to medical wards in South Africa. Scientific Reports 2016, 6: 19391. PMID: 26786396, PMCID: PMC4726405, DOI: 10.1038/srep19391.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCoinfectionDrug Resistance, BacterialFemaleHIV InfectionsHumansMaleMass ScreeningMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisNucleic Acid Amplification TechniquesReproducibility of ResultsRifampinSouth AfricaTuberculosis, Multidrug-ResistantYoung AdultConceptsChest X-rayMTB/RIFMedical wardsScreening toolAdditional TB casesInfection control actionsUtility of GeneXpertTB/HIVConsecutive adult patientsProportion of patientsRifampicin-resistant tuberculosisDrug-resistant tuberculosisLarge public hospitalTB diseaseAdult patientsStandard careTB casesTB screeningMedical admissionsMedical chartsHospital inpatientsSputum specimensGeneXpertPatientsRifampicin resistance
2014
High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova.
Jenkins HE, Crudu V, Soltan V, Ciobanu A, Domente L, Cohen T. High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova. European Respiratory Journal 2014, 43: 1132-41. PMID: 24558181, PMCID: PMC4005038, DOI: 10.1183/09031936.00203613.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisMDR-TB diagnosisMDR-TB casesTB treatmentFirst-line TB drugsAmbulatory TB treatmentMDR-TB riskDrug susceptibility testingNosocomial transmissionInitial diagnosisPercentage of individualsTB drugsTuberculosis treatmentEarly treatmentHigh riskSputum specimensSurveillance databasePrevious incarcerationDrug resistanceMultidrug resistanceDiagnosisTreatmentBaseline resistanceRapid appearanceRisk