2012
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology 2012, 225: 217-226. PMID: 22842765, PMCID: PMC3552490, DOI: 10.1007/s00213-012-2809-7.Peer-Reviewed Original ResearchConceptsChronic clozapineLysergic acid diethylamideAtypical antipsychotic drug actionHead-twitch behaviorC-fosAntipsychotic-like activityAntipsychotic drug actionTherapeutic-like effectsMouse somatosensory cortexSchizophrenia-like behavioral alterationsEgr-2Egr-1Chronic haloperidolChronic treatmentClozapine administrationDrug therapyOptimal treatmentSomatosensory cortexSingle administrationAntipsychotic drugsMurine modelMouse modelRodent modelsSerotonin 5Behavioral alterations
2011
Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring. Journal Of Neuroscience 2011, 31: 1863-1872. PMID: 21289196, PMCID: PMC3037097, DOI: 10.1523/jneurosci.4230-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdult ChildrenAnimalsAntipsychotic AgentsCerebral CortexDisease Models, AnimalDown-RegulationEarly Growth Response Protein 1Early Growth Response Protein 2FemaleFrontal LobeGlutamic AcidHallucinogensInfluenza A Virus, H1N1 SubtypeMaternal-Fetal ExchangeMiceNeural PathwaysOrthomyxoviridae InfectionsPregnancyProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaUp-RegulationConceptsInfluenza viral infectionViral infectionMouse modelAdult offspringSchizophrenia-like alterationsPrenatal viral infectionHead-twitch responseSchizophrenia-like psychosisInfluenza A/WSN/33 virusMetabotropic glutamate receptorsAntipsychotic-like effectsPrevention of schizophreniaSpontaneous locomotor activityHigher c-fosEffects of hallucinogensBehavioral changesEgr-2 expressionEtiology of schizophreniaMechanism of actionMaternal infectionInfected mothersMaternal exposureGlutamate agonistsAntipsychotic drugsGlutamate system