2014
Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding
Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC. Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding. Cell 2014, 156: 495-509. PMID: 24462248, PMCID: PMC4101521, DOI: 10.1016/j.cell.2014.01.008.Peer-Reviewed Original ResearchConceptsPOMC neuronsMaternal high-fat diet (HFD) feedingOrexigenic agouti-related peptide (AgRP) neuronsHealth outcomesMaternal high-fat feedingHigh-fat diet feedingImpaired glucose-stimulated insulin secretionMaternal HFD feedingGlucose-stimulated insulin secretionImpaired glucose homeostasisOffspring health outcomesHigh-fat feedingPOMC projectionsParasympathetic innervationHFD feedingMaternal overnutritionPeptide neuronsAbnormal insulinAnorexigenic proopiomelanocortinParaventricular nucleusDiet feedingInsulin secretionMelanocortin circuitryNeuropeptide expressionLong-term effects
2012
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism. Physiological Reviews 2012, 92: 1479-1514. PMID: 22811431, PMCID: PMC3746174, DOI: 10.1152/physrev.00022.2011.Peer-Reviewed Original ResearchConceptsSirtuin 1Sirtuin 3Nonalcoholic fatty liver diseaseMammalian sirtuin 1Multiple metabolic benefitsFatty liver diseaseDiet-induced obesityType 2 diabetesActivation of sirtuinsLiver diseaseCellular energy storesMetabolic benefitsMetabolic disordersPharmacological meansEnergy homeostasisPhysiological modulatorDependent deacetylasesMetabolic processesSirtuinsCellular energy homeostasisEnergy storesCellular sensorsEnergy statusAnabolic processesCatabolic process