2010
Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus
Sotonyi P, Mezei G, Racz B, Dallman MF, Abizaid A, Horvath TL. Gonadotropin-Releasing Hormone Fibers Contact POMC Neurons in the Hypothalamic Arcuate Nucleus. Reproductive Sciences 2010, 17: 1024-1028. PMID: 20713970, DOI: 10.1177/1933719110378346.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusFemaleGonadotropin-Releasing HormoneMiceNerve FibersNeuronsPresynaptic TerminalsPro-OpiomelanocortinConceptsArcuate nucleusGonadotropin-releasing hormone (GnRH) neuronsPOMC cell bodiesEnergy expenditureHypothalamic arcuate nucleusHypothalamic neuronal populationsMelanocyte stimulating hormoneHormone neuronsPOMC neuronsAnorexigenic proopiomelanocortinStimulating hormoneAnatomical proximityAxon terminalsGonadal axisGlucose homeostasisPeripheral signalsNeuronal populationsCell bodiesDirect appositionGnRHEnergy metabolismNeuronsMetabolic stateHormoneProopiomelanocortin
2007
Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge
Naftolin F, Garcia-Segura LM, Horvath TL, Zsarnovszky A, Demir N, Fadiel A, Leranth C, Vondracek-Klepper S, Lewis C, Chang A, Parducz A. Estrogen-Induced Hypothalamic Synaptic Plasticity and Pituitary Sensitization in the Control of the Estrogen-Induced Gonadotrophin Surge. Reproductive Sciences 2007, 14: 101-116. PMID: 17636222, DOI: 10.1177/1933719107301059.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEstrogensFemaleGonadotropin-Releasing HormoneGonadotropinsGonadsHumansHypothalamusInsulin-Like Growth Factor IMenstrual CycleNeuronal PlasticityNeuronsPituitary GlandRatsSynapsesConceptsGnRH secretionPituitary gonadotrophsGonadotrophin surgeSynaptic plasticityInsulinlike growth factor 1Triggering of ovulationOvarian estrogen secretionGrowth factor-1Neural cell adhesion moleculePituitary sensitizationGnRH cellsGnRH neuronsEstrogen secretionHypothalamic neuronsGonadal functionCell adhesion moleculeSex steroidsSpecific immunoneutralizationOvarian cycleGonadotrophsAdhesion moleculesEstrogenMaximal sensitizationSecretionFactor 1
2004
Direct visual and circadian pathways target neuroendocrine cells in primates
Abizaid A, Horvath B, Keefe DL, Leranth C, Horvath TL. Direct visual and circadian pathways target neuroendocrine cells in primates. European Journal Of Neuroscience 2004, 20: 2767-2776. PMID: 15548220, DOI: 10.1111/j.1460-9568.2004.03737.x.Peer-Reviewed Original ResearchConceptsSuprachiasmatic nucleusRetinal inputNeuroendocrine cellsDirect retinal inputHormone-releasing hormoneNon-human primatesHypothalamic suprachiasmatic nucleusSCN efferentsHypothalamic areaHypothalamic neuronsHypothalamic sitesMonosynaptic pathwayVisual afferentsHypothalamic regulatorGonadal axisHormone releaseNeuroendocrine functionPituitary gonadotropsPhotic modulationNeuronsCircadian pacemakerVervet monkeysPresent studyTracing techniquesCircadian clock
2001
Oestrogen‐Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback
Zsarnovszky A, Horvath TL, Garcia‐Segura L, Horvath B, Naftolin F. Oestrogen‐Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback. Journal Of Neuroendocrinology 2001, 13: 22-28. DOI: 10.1111/j.1365-2826.2001.00602.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusChlorocebus aethiopsEstradiolFeedbackFemaleGonadotropin-Releasing HormoneGonadotropinsImmunoenzyme TechniquesNeuronal PlasticityNeuronsOvariectomySynapsesConceptsGnRH neuronesGnRH cellsDay 1Day 2Day 8Pg/Gonadotropin secretionArcuate nucleusOestrogen-induced LH surgeAfrican green monkeysGonadotropin feedbackInhibitory innervationEstrogen modulationOVX monkeysLH surgeSerum concentrationsExcitatory inputsInhibitory synapsesExcitatory synapsesInhibitory inputsSynaptic connectionsGnRHNeuronesGreen monkeysSynapsesOestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback.
Zsarnovszky A, Horvath T, Garcia-Segura L, Horvath B, Naftolin F. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. Journal Of Neuroendocrinology 2001, 13: 22-8. PMID: 11123512, DOI: 10.1046/j.1365-2826.2001.00602.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusChlorocebus aethiopsEstradiolFeedbackFemaleGonadotropin-Releasing HormoneGonadotropinsImmunoenzyme TechniquesNeuronal PlasticityNeuronsOvariectomySynapsesConceptsGnRH neuronesGnRH cellsDay 1Day 2Day 8Pg/Gonadotropin secretionOestrogen-induced LH surgeAfrican green monkeysInhibitory innervationEstrogen modulationOVX monkeysLH surgeArcuate nucleusSerum concentrationsExcitatory inputsInhibitory synapsesExcitatory synapsesInhibitory inputsSynaptic connectionsGnRHNeuronesGreen monkeysSynapsesPronounced alterations
1998
Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat
Horvath T, Cela V, van der Beek E. Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat. Brain Research 1998, 795: 277-281. PMID: 9622650, DOI: 10.1016/s0006-8993(98)00208-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsEstrusFemaleGonadotropin-Releasing HormoneMaleNeuronsPreoptic AreaRatsRats, Sprague-DawleySex CharacteristicsVasoactive Intestinal PeptideConceptsVasoactive intestinal peptideGnRH neuronsInvolvement of VIPGonadotrophin-releasing hormoneDouble-labeling immunocytochemistryGender-specific regulationVIP axonsVIP boutonsVIP fibersGonadotrophin releaseIntestinal peptideFemale ratsDimorphic interactionNeuronsRatsAxonsHypothalamusBoutonsHormone
1997
Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies
Van Der Beek E, Horvath T, Wiegant V, Van Den Hurk R, Buijs R. Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies. The Journal Of Comparative Neurology 1997, 384: 569-579. PMID: 9259490, DOI: 10.1002/(sici)1096-9861(19970811)384:4<569::aid-cne6>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingFemaleGonadotropin-Releasing HormoneHypothalamusImmunohistochemistryMicroscopy, ElectronNeural PathwaysNeuronsRatsRats, Sprague-DawleySuprachiasmatic NucleusConceptsSuprachiasmatic nucleusFemale ratsGnRH systemGnRH-immunoreactive cell bodiesGonadotropin-releasing hormone (GnRH) neuronsDaily LH surgesImplantation of estrogenOvariectomized rats resultsRostral ventrolateral portionGonadotropin-releasing hormone (GnRH) systemVasoactive intestinal polypeptideElectron microscopic immunocytochemical studyHormone neuronsGnRH neuronsIntestinal polypeptideLH surgeMonosynaptic pathwayPutative transmittersAnterograde tracerPreoptic areaNeuronal pathwaysRats resultsVentrolateral portionBilateral projectionsFemale rodentsThe Interactive Language of the Hypothalamus for the Gonadotropin Releasing Hormone (GNRH) System
Kalra S, Horvath T, Naftolin F, Xu B, Pu S, Kalra P. The Interactive Language of the Hypothalamus for the Gonadotropin Releasing Hormone (GNRH) System. Journal Of Neuroendocrinology 1997, 9: 569-576. PMID: 9283045, DOI: 10.1046/j.1365-2826.1997.00619.x.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAnimalsFemaleGonadotropin-Releasing HormoneHumansHypothalamusMaleNeurotransmitter AgentsControl of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity
Horvath TL, Garcia-segura LM, Naftolin F. Control of gonadotropin feedback: The possible role of estrogen-induced hypothalamic synaptic plasticity. Gynecological Endocrinology 1997, 11: 139-143. PMID: 9174856, DOI: 10.3109/09513599709152525.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusEstrogensFeedbackFemaleGamma-Aminobutyric AcidGonadotropin-Releasing HormoneGonadotropinsHumansMenstrual CycleNeuronal PlasticityRatsSynaptic TransmissionConceptsSynaptic plasticityEstrogen-induced synaptic plasticityHypothalamic arcuate nucleusPreovulatory gonadotropin surgeInhibitory synaptic connectionsGonadotropin feedbackGonadotropin surgeArcuate nucleusPreovulatory surgePituitary gonadotrophsSynaptic connectionsSecretion resultsRecent evidenceMassive releaseEstrogenPossible roleGonadotropinHypothalamusCritical eventsGonadotrophs
1995
Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus
Horvath T, Leranth C, Kalra S, Naftolin F. Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus. Brain Research 1995, 675: 321-324. PMID: 7540929, DOI: 10.1016/0006-8993(94)01374-q.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusFemaleGalaninGonadotropin-Releasing HormoneHypothalamus, MiddleImmunohistochemistryNeuronsNeuropeptidesPeptidesRatsRats, Sprague-DawleyReceptors, EstrogenConceptsPituitary hormone secretionEstrogen receptorHormone secretionMediobasal hypothalamusEstrogen receptor immunoreactivityHypothalamic luteinizing hormoneArcuate nucleus neuronsRat mediobasal hypothalamusPopulations of neuronsGalanin neuronsReceptor immunoreactivityOvarian steroidsEstrogen effectsNucleus neuronsLuteinizing hormoneFemale ratsHormone releaseGalaninHypothalamusNeuronsVibratome sectionsImmunoreactivityReceptorsHormoneSecretionDistribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase
Herbison A, Horvath T, Naftolin F, Leranth C. Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase. Neuroendocrinology 1995, 61: 1-10. PMID: 7731492, DOI: 10.1159/000126810.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChlorocebus aethiopsFemaleGonadotropin-Releasing HormoneHypothalamusImmunohistochemistryMacaca fascicularisNeuronsReceptors, EstrogenTyrosine 3-MonooxygenaseConceptsER-immunoreactive cellsHormone-releasing hormoneER immunoreactivityMonkey hypothalamusTyrosine hydroxylaseDouble-labeling experimentsProgesterone receptorDopaminergic neuronesLHRH neuronesEstrogen receptor-immunoreactive cellsReceptor-immunoreactive cellsPituitary hormone secretionSpecific hypothalamic nucleiTH-immunoreactive cellsPR-containing cellsDopamine-containing neuronesHypothalamic dopaminergic neuronesAfrican green monkeysLHRH neuronsPeriventricular areaSteroid statusArcuate nucleusHormone secretionHypothalamic nucleiPrimate hypothalamus
1993
Luteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas
Horvath T, Naftolin F, Leranth C. Luteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas. Journal Of Neuroendocrinology 1993, 5: 71-79. PMID: 8097941, DOI: 10.1111/j.1365-2826.1993.tb00365.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCerebral VentriclesColchicineDopamineFemaleGamma-Aminobutyric AcidGlutamate DecarboxylaseGonadotropin-Releasing HormoneImmunohistochemistryMicroscopy, ElectronNeuronsOxidopaminePhytohemagglutininsPreoptic AreaRatsRats, Sprague-DawleySynapsesTissue FixationTyrosine 3-MonooxygenaseConceptsHormone-releasing hormoneMedial preoptic areaGlutamic acid decarboxylasePhaseolus vulgaris leucoagglutininZona incertaPreoptic areaTyrosine hydroxylaseGlutamic acid decarboxylase-immunoreactive neuronsDopamine axonsTyrosine hydroxylase-immunoreactive boutonsAcid decarboxylaseGamma-aminobutyric acid (GABA) neuronsRat medial preoptic areaAnterior periventricular areaDesipramine-pretreated ratsDopamine axon terminalsAnteroventral periventricular nucleusCell of originEarly morphological signsDopaminergic connectionsGABA neuronsGABA cellsPeriventricular areaAcute degenerationSynaptic contacts
1992
Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis
Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 1992, 131: 2461-2467. PMID: 1425443, DOI: 10.1210/endo.131.5.1425443.Peer-Reviewed Original ResearchConceptsPituitary LH releaseLH releaseOvariectomized ratsMediobasal hypothalamusSynaptic connectionsNPY-immunoreactive axonsBeta-endorphin systemSynaptic membrane specializationsRat mediobasal hypothalamusDirect synaptic connectionsDiaminobenzidine reactionLHRH neuronsNPY neuronsDual effectHypothalamic NPYLH secretionMedial basalLHRH secretionOvarian steroidsPrecise neural mechanismsFemale ratsAxon terminalsElectron microscopic examinationPeptidergic systemsNeuroendocrine regulation