2003
Ghrelin as a potential anti-obesity target.
Horvath TL, Castañeda T, Tang-Christensen M, Pagotto U, Tschöp MH. Ghrelin as a potential anti-obesity target. Current Pharmaceutical Design 2003, 9: 1383-95. PMID: 12769730, DOI: 10.2174/1381612033454748.Peer-Reviewed Original ResearchConceptsPositive energy balancePotential anti-obesity targetEndogenous growth hormone secretagogueEffective pharmacological treatmentAnti-obesity targetGrowth hormone secretagoguesNumerous target tissuesPeptide hormone ghrelinGhrelin antagonistGhrelin actionPharmacological treatmentHormone ghrelinFood intakeHormone secretagoguesPharmacological approachesGhrelinPleiotropic hormoneFat oxidationNeuroendocrine regulationCompensatory mechanismsEnergy homeostasisBlood streamTarget tissuesExact mechanismObesity
1999
Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations
Horvath T, Diano S, van den Pol A. Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal Of Neuroscience 1999, 19: 1072-1087. PMID: 9920670, PMCID: PMC6782143, DOI: 10.1523/jneurosci.19-03-01072.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsChlorocebus aethiopsEndocrine GlandsFemaleHypothalamusIntracellular Signaling Peptides and ProteinsMaleMetabolismNeural PathwaysNeuronsNeuropeptide YNeuropeptidesOrexin ReceptorsOrexinsRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, G-Protein-CoupledReceptors, LeptinReceptors, NeuropeptideSynapsesConceptsHypothalamic functionCentral regulationHypocretin-containing neuronsLateral hypothalamic cellsLeptin receptor immunoreactivityNeuropeptide Y cellsDirect synaptic contactsNeuropeptide Y systemEndocrine regulationEndocrine processesNPY releaseReceptor immunoreactivityExcitatory actionHypocretin cellsSynaptic contactsArcuate nucleusLateral hypothalamusPrimate hypothalamusLeptin receptorSame neuronsHypothalamic cellsSynaptic regulationAdipose tissueHypocretinNPY
1998
Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus
Diano S, Kalra S, Sakamoto H, Horvath T. Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus. Brain Research 1998, 812: 256-259. PMID: 9813356, DOI: 10.1016/s0006-8993(98)00936-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsFemaleHypothalamusNeuronsObesityRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, EstrogenReceptors, LeptinConceptsLeptin receptorEstrogen receptorNeuronal perikaryaPeripheral signalsEstrogen receptor-containing neuronsParvicellular paraventricular nucleusReceptor-containing neuronsMedial preoptic areaVentromedial hypothalamic nucleusFemale rat hypothalamusArcuate nucleusHypothalamic nucleiFemale ratsParaventricular nucleusPreoptic areaGonadal functionHypothalamic sectionsPeriventricular regionRat hypothalamusNeuroendocrine mechanismsReceptorsExtensive colocalizationLeptinHypothalamusPerikaryaLeptin Receptor Immunoreactivity is Associated with the Golgi Apparatus of Hypothalamic Neurones and Glial Cells
Diano S, Kalra S, Horvath T. Leptin Receptor Immunoreactivity is Associated with the Golgi Apparatus of Hypothalamic Neurones and Glial Cells. Journal Of Neuroendocrinology 1998, 10: 647-650. PMID: 9744481, DOI: 10.1046/j.1365-2826.1998.00261.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsGolgi ApparatusHypothalamusMaleMicroscopy, ElectronNeurogliaNeuronsRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, LeptinConceptsLeptin receptor immunoreactivityReceptor immunoreactivityPerikaryal membraneGlial cellsGolgi apparatusHypothalamic neuronesCentral nervous systemDifferent second messenger systemsHypothalamic neuronalPeripheral hormonesDentate gyrusSecond messenger systemsEndocrine functionLeptin receptorHypothalamic cellsNervous systemThyroid axisImmunoreactivityCentral mechanismsLeptinIntracellular mechanismsTrans cisternaeNeuronesMessenger systemsPredominant localization