Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord
Horvath B, Spies C, Warden CH, Diano S, Horvath TL. Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord. Brain Research 2002, 955: 260-263. PMID: 12419545, DOI: 10.1016/s0006-8993(02)03364-4.Peer-Reviewed Original ResearchConceptsSpinal cordExpression of UCP2Primary sensory afferentsMechanisms of painProtein 2Primary painSensory afferentsSubstantia gelatinosaVentral hornSubstance P.Axon terminalsCordEnergy homeostasisUCP2 expressionDirect appositionTemperature sensationMitochondrial protonophorePainAfferentsUCP2Mitochondrial uncouplerCellular energy homeostasisExpressionPerikaryaAxonsUncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold
Horvath B, Spies C, Horvath G, Kox WJ, Miyamoto S, Barry S, Warden CH, Bechmann I, Diano S, Heemskerk J, Horvath TL. Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochemical Pharmacology 2002, 64: 369-374. PMID: 12147287, DOI: 10.1016/s0006-2952(02)01167-x.Peer-Reviewed Original ResearchConceptsCentral nervous systemTemperature sensationNervous systemBasal forebrain areasMajor risk factorAcute ethanol exposureAcute alcohol consumptionImpairment of painPeripheral energy expenditureAbuse of ethanolProtein 2Ethanol-induced toleranceWild-type animalsUCP2 knockoutPain thresholdTime of recoveryInduces toleranceRisk factorsEthanol exposureForebrain areasAxon terminalsNeuronal responsesAcute exposureAlcohol consumptionEnergy homeostasis