2022
TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice
Stoiljkovic M, Gutierrez KO, Kelley C, Horvath TL, Hajós M. TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. Journal Of Alzheimer's Disease 2022, 88: 837-847. PMID: 34120899, PMCID: PMC8898080, DOI: 10.3233/jad-210041.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseMicroglial functionTREM2 functionTheta-phase gamma-amplitude couplingHippocampal network functionSpontaneous epileptiform seizuresNetwork oscillationsTransgenic AD modelHippocampal neuronal excitabilityMyeloid cells 2Clinical Alzheimer's diseaseWild-type miceHippocampal network oscillationsHippocampal pathophysiologyProgressive dementiaTau pathologyUrethane anesthesiaAD pathophysiologyNeuronal excitabilityEpileptiform seizuresEpileptic activityAD modelTREM2Disease pathologyCells 2Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid‐β pathology
Stoiljkovic M, Gutierrez K, Kelley C, Horvath T, Hajos M. Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid‐β pathology. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054379.Peer-Reviewed Original ResearchAlzheimer's diseaseNeuronal network oscillationsMicroglial functionNetwork oscillationsStimulation-induced hippocampal theta oscillationTheta-phase gamma-amplitude couplingImpact of TREM2Spontaneous epileptiform seizuresTransgenic AD modelMyeloid cells 2Wild-type miceHippocampal network oscillationsHippocampal theta oscillationsProgressive dementiaTau pathologyUrethane anesthesiaLocal field potentialsCA1 regionFunctional impairmentAβ overproductionEpileptiform seizuresAD modelTREM2Phase-amplitude couplingDisease pathology
2016
Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation
Hermes G, Nagy D, Waterson M, Zsarnovszky A, Varela L, Hajos M, Horvath TL. Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation. Molecular Metabolism 2016, 5: 415-421. PMID: 27257601, PMCID: PMC4877662, DOI: 10.1016/j.molmet.2016.04.002.Peer-Reviewed Original ResearchMouse modelSynaptic plasticityMental illnessUCP2 knockout miceNMDA receptor blockadeHigher brain regionsKO mouse modelMajor psychiatric illnessProtein 2 expressionHigher brain functionsReceptor blockadePsychiatric illnessNeuronal plasticityKnockout miceNeural transmissionCellular resilienceCortical activityBrain regionsProfound disorderBrain functionMitochondrial impairmentIllnessNetwork oscillationsMitochondrial functionProtein 2