Systemic Management for Advanced Hepatocellular Carcinoma: A Review of the Molecular Pathways of Carcinogenesis, Current and Emerging Therapies, and Novel Treatment Strategies
Saffo S, Taddei TH. Systemic Management for Advanced Hepatocellular Carcinoma: A Review of the Molecular Pathways of Carcinogenesis, Current and Emerging Therapies, and Novel Treatment Strategies. Digestive Diseases And Sciences 2019, 64: 1016-1029. PMID: 30887150, DOI: 10.1007/s10620-019-05582-x.BooksConceptsAdvanced hepatocellular carcinomaHepatocellular carcinomaTreatment strategiesMulti-targeted tyrosine kinase inhibitorSystemic managementGeneral host factorsEffective systemic therapyInitial treatment strategyMulti-modal therapyOverall tumor burdenCancer-related deathNovel treatment strategiesTyrosine kinase inhibitorsDifferent treatment classesKey molecular targetsInoperable diseaseCheckpoint inhibitorsEmerging TherapiesMost patientsDurable cureSystemic therapyLandmark trialsTumor burdenTelomerase reverse transcriptaseTherapy