Acute Myeloid Leukemia in Mice Associated with Retrovirally-Mediated Overexpression of HOXB4
Zhang H, Chen W, Rogulina S, Lee H, Forget B. Acute Myeloid Leukemia in Mice Associated with Retrovirally-Mediated Overexpression of HOXB4. Blood 2008, 112: 4484. DOI: 10.1182/blood.v112.11.4484.4484.Peer-Reviewed Original ResearchRetroviral integration sitesOverexpression of HOXB4Hematopoietic stem cellsIntegration sitesBone marrow cellsIntron 1Ability of HSCsIntrons of genesMurine bone marrow cellsEffect of knockdownNorthern blot analysisStem cell markers c-KitControl bone marrow cellsN-ras genePRDM16 geneLMO2 geneKb upstreamMRNA accumulationHOXB4Leukemic bone marrow cellsGFP retrovirusCombinatorial fashionGenesLeukemic cellsIntron 2