2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2021
Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis
Zeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoVViral sheddingImmune responseSpontaneous modelAnimal modelsDisease pathogenesisSARS-CoV-2 infectionCOVID-19Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusChimeric SARS-CoVRole of comorbiditiesCoronavirus disease 2019 (COVID-19) pandemicShort-term immune responseWild-type miceSeverity of diseaseOrgan-specific pathologySARS-CoV-2 virusDisease 2019 pandemicAfrican green monkeysTest therapeuticsVaccine approachesNonfatal diseaseTissue involvement
1998
Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins
Compton S. Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins. Advances In Experimental Medicine And Biology 1998, 440: 25-31. PMID: 9782261, DOI: 10.1007/978-1-4615-5331-1_4.Peer-Reviewed Original ResearchConceptsCMT93 cellsReceptor geneEnterotropic mouse hepatitis virus infectionMouse hepatitis virus infectionHepatitis virus infectionMHV-A59 infectionLimited tissue tropismCell receptor interactionsMHV infectionNeonatal miceVirus infectionIntestinal mucosaReceptor mRNAMouse hepatitisBHK cellsReceptor isoformsUnidentified receptorInfectionMonoclonal antibodiesTissue tropismVero cellsReceptor interactionRI useReceptor proteinReceptors
1995
Multiple Receptor-Dependent Steps Determine the Species Specificity of HCV-229E Infection
Levis R, Cardellichio C, Scanga C, Compton S, Holmes K. Multiple Receptor-Dependent Steps Determine the Species Specificity of HCV-229E Infection. Advances In Experimental Medicine And Biology 1995, 380: 337-343. PMID: 8830504, DOI: 10.1007/978-1-4615-1899-0_55.Peer-Reviewed Original ResearchConceptsHuman aminopeptidase NSpecies specificityBrush border membraneCell linesVirus bindingHCV-229EHuman cellsAminopeptidase NCellular receptorsHCV 229E.SpeciesCell sortingIntestinal brush border membraneHuman coronavirus 229EAnimal coronavirusesBindsMembraneVirus penetrationCellsVirus yieldBorder membraneViral spikeCoronavirus 229EBindingInfection
1994
Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors
Compton S. Enterotropic Strains of Mouse Coronavirus Differ in Their Use of Murine Carcinoembryonic Antigen-Related Glycoprotein Receptors. Virology 1994, 203: 197-201. PMID: 8030279, PMCID: PMC7131022, DOI: 10.1006/viro.1994.1475.Peer-Reviewed Original ResearchConceptsSJL miceLimited tissue tropismMHV-RIEnterotropic mouse hepatitis virusBALB/c miceTissue tropismMonoclonal antibody CC1BALB/cMouse hepatitis virusRole of receptorsMurine carcinoembryonic antigenC miceEnterotropic strainsHepatitis virusCarcinoembryonic antigenBHK cellsInfectionMiceDifferent receptorsReceptorsCell linesGlycoprotein receptorsMurine tissuesMouse coronavirusMHV
1990
Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?
Holmes K, Williams R, Cardellichio C, Compton S, Stephensen C, Snyder S, Frana M, Jiang G, Smith A, Knobler R. Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity? Advances In Experimental Medicine And Biology 1990, 276: 37-44. PMID: 1966425, DOI: 10.1007/978-1-4684-5823-7_6.Peer-Reviewed Original ResearchConceptsSJL/J miceNormal target tissuesJ miceMHV-A59BALB/c miceTarget tissuesVirus overlay protein blot assaySJL/JMouse hepatitis virusSusceptible miceBinding of virionsC miceHepatitis virusOnly receptorBlot assaysVirus bindingMiceTissue tropismIntestine membranesMurine virusesHepatocyte membraneProtein blot assayVirusInfectionMolecular mechanisms