Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control
Marcelo KL, Sills TM, Coskun S, Vasavada H, Sanglikar S, Goldie LC, Hirschi KK. Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control. Developmental Cell 2013, 27: 504-515. PMID: 24331925, PMCID: PMC3994666, DOI: 10.1016/j.devcel.2013.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde OxidoreductasesAnimalsAntineoplastic AgentsCell Cycle CheckpointsCell DifferentiationCore Binding Factor Alpha 2 SubunitCyclin-Dependent Kinase Inhibitor p27Embryo Culture TechniquesEndothelial CellsFemaleHematopoietic Stem CellsLac OperonLentivirusMaleMiceMice, KnockoutPregnancyProto-Oncogene Proteins c-kitProto-Oncogene Proteins c-mybReceptor, Notch1Signal TransductionTretinoinConceptsCell cycle controlEndothelial cell specificationEndothelial cell developmentNotch signalingCell specificationCell developmentPrimordial endothelial cellsHemogenic endothelial cellsRetinoic acidCell cycle regulationC-kitHuman stem cellsRas regulationEndothelial cellsMolecular signalsStem cellsSignalingP27 expressionP27RegulationCellsEmbryogenesisClinical therapyMechanismExpression