2014
Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy
Sedigh-Sarvestani M, Thuku G, Sunderam S, Parkar A, Weinstein S, Schiff S, Gluckman B. Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy. Journal Of Neuroscience 2014, 34: 1105-1114. PMID: 24453303, PMCID: PMC3898281, DOI: 10.1523/jneurosci.3103-13.2014.Peer-Reviewed Original ResearchConceptsRapid eye movement (REM) sleepNonrapid eye movement sleepEye movement sleepHippocampal theta rhythmState of vigilanceTemporal lobe epilepsyMovement sleepSeizure onsetLobe epilepsySeizure susceptibilityTheta rhythmChronic spontaneous seizuresNatural behavioral statesTetanus toxin modelHalf of baselineSpontaneous seizuresSeizure rateVentral hippocampusToxin modelSeizuresSurvival analysisTetanus toxinTherapeutic potentialREM boutsProminent theta
2009
Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit
Schachter S, Guttag J, Schiff S, Schomer D, Contributors S. Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit. Epilepsy & Behavior 2009, 16: 3-46. PMID: 19780225, PMCID: PMC8118381, DOI: 10.1016/j.yebeh.2009.06.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrain MappingChildDrug ResistanceElectric Stimulation TherapyElectroencephalographyEngineeringEpilepsyHumansMagnetic Resonance ImagingMedical Laboratory ScienceMicroelectrodesNanoparticlesNeuronsNeurosurgeryNeurotoxinsPredictive Value of TestsSeizuresSpectroscopy, Near-InfraredTomography, Emission-Computed, Single-PhotonTomography, OpticalTranscranial Magnetic StimulationConceptsTreatment systemEvaluation of patientsTreatment of patientsGroup of cliniciansEpilepsy surgeryEngineering technologyFurther technological developmentEpilepsySeizure onset detectionPatientsEngineersSeizure predictionTechnologyApplicationsOnset detectionSurgeryCliniciansPhysiciansUnmetDiagnosis