2014
Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy
Sedigh-Sarvestani M, Thuku G, Sunderam S, Parkar A, Weinstein S, Schiff S, Gluckman B. Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy. Journal Of Neuroscience 2014, 34: 1105-1114. PMID: 24453303, PMCID: PMC3898281, DOI: 10.1523/jneurosci.3103-13.2014.Peer-Reviewed Original ResearchConceptsRapid eye movement (REM) sleepNonrapid eye movement sleepEye movement sleepHippocampal theta rhythmState of vigilanceTemporal lobe epilepsyMovement sleepSeizure onsetLobe epilepsySeizure susceptibilityTheta rhythmChronic spontaneous seizuresNatural behavioral statesTetanus toxin modelHalf of baselineSpontaneous seizuresSeizure rateVentral hippocampusToxin modelSeizuresSurvival analysisTetanus toxinTherapeutic potentialREM boutsProminent theta
2013
Frequency dependence of behavioral modulation by hippocampal electrical stimulation
La Corte G, Wei Y, Chernyy N, Gluckman B, Schiff S. Frequency dependence of behavioral modulation by hippocampal electrical stimulation. Journal Of Neurophysiology 2013, 111: 470-480. PMID: 24198322, PMCID: PMC3921403, DOI: 10.1152/jn.00523.2013.Peer-Reviewed Original ResearchFRET excited ratiometric oxygen sensing in living tissue
Ingram J, Zhang C, Xu J, Schiff S. FRET excited ratiometric oxygen sensing in living tissue. Journal Of Neuroscience Methods 2013, 214: 45-51. PMID: 23333398, PMCID: PMC3664065, DOI: 10.1016/j.jneumeth.2013.01.002.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsColoring AgentsComputer SystemsConvulsantsFluorescence Resonance Energy TransferGlassHippocampusIn Vitro TechniquesLuminescent MeasurementsMetal NanoparticlesMicroelectrodesOrganoplatinum CompoundsOximetryOxygen ConsumptionPorphyrinsPyramidal CellsQuantum DotsRatsRats, Sprague-DawleySingle-Cell AnalysisConceptsInterstitial oxygen concentrationGlass substratesPolymer matrixBiocompatible sensorsInert polymer matrixDynamic analysisOptical sensorsMatrix consistingTemporal resolutionSensorsMillisecond temporal resolutionOxygen concentrationQuantum dotsMatrixRatiometric oxygenFluorescence resonance energy transferEnergy transfer
2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell typesModulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel role
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitability
2006
Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals
Sunderam S, Chernyy N, Mason J, Peixoto N, Weinstein S, Schiff S, Gluckman B. Seizure Modulation with Applied Electric Fields in Chronically Implanted Animals. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 1612-1615. PMID: 17946910, PMCID: PMC3547984, DOI: 10.1109/iembs.2006.259454.Peer-Reviewed Original Research
2003
In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields
Richardson K, Gluckman B, Weinstein S, Glosch C, Moon J, Gwinn R, Gale K, Schiff S. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 2003, 44: 768-777. PMID: 12790889, DOI: 10.1046/j.1528-1157.2003.35402.x.Peer-Reviewed Original ResearchMeSH KeywordsAmplifiers, ElectronicAnimalsDisease Models, AnimalElectric StimulationElectric Stimulation TherapyElectrodes, ImplantedElectronics, MedicalEpilepsyHippocampusHumansKainic AcidKindling, NeurologicMaleMembrane PotentialsMicroelectrodesRatsRats, Sprague-DawleySeizuresStereotaxic TechniquesConceptsElectric field modulationRadial electric fieldElectric fieldElectric field controlField modulationMicroelectrode pairsCharge deliveryControl systemElectrode geometryField controlSeizure onset detectionElectrodeElectric field stimulationElectronicsStimulation electrodesFieldFirst resultsNovel approachExperiments
2002
Decreased Neuronal Synchronization during Experimental Seizures
Netoff T, Schiff S. Decreased Neuronal Synchronization during Experimental Seizures. Journal Of Neuroscience 2002, 22: 7297-7307. PMID: 12177225, PMCID: PMC6757884, DOI: 10.1523/jneurosci.22-16-07297.2002.Peer-Reviewed Original Research
2001
Adaptive Electric Field Control of Epileptic Seizures
Gluckman B, Nguyen H, Weinstein S, Schiff S. Adaptive Electric Field Control of Epileptic Seizures. Journal Of Neuroscience 2001, 21: 590-600. PMID: 11160438, PMCID: PMC6763796, DOI: 10.1523/jneurosci.21-02-00590.2001.Peer-Reviewed Original Research
2000
Brain chirps: spectrographic signatures of epileptic seizures
Schiff S, Colella D, Jacyna G, Hughes E, Creekmore J, Marshall A, Bozek-Kuzmicki M, Benke G, Gaillard W, Conry J, Weinstein S. Brain chirps: spectrographic signatures of epileptic seizures. Clinical Neurophysiology 2000, 111: 953-958. PMID: 10825700, DOI: 10.1016/s1388-2457(00)00259-5.Peer-Reviewed Original Research
1998
Periodic Orbits: A New Language for Neuronal Dynamics
So P, Francis J, Netoff T, Gluckman B, Schiff S. Periodic Orbits: A New Language for Neuronal Dynamics. Biophysical Journal 1998, 74: 2776-2785. PMID: 9635732, PMCID: PMC1299619, DOI: 10.1016/s0006-3495(98)77985-8.Peer-Reviewed Original Research
1996
Electric field suppression of epileptiform activity in hippocampal slices
Gluckman B, Neel E, Netoff T, Ditto W, Spano M, Schiff S. Electric field suppression of epileptiform activity in hippocampal slices. Journal Of Neurophysiology 1996, 76: 4202-4205. PMID: 8985916, DOI: 10.1152/jn.1996.76.6.4202.Peer-Reviewed Original Research
1995
Looking for chaos in brain slices
Aitken P, Sauer T, Schiff S. Looking for chaos in brain slices. Journal Of Neuroscience Methods 1995, 59: 41-48. PMID: 7475249, DOI: 10.1016/0165-0270(94)00192-j.Peer-Reviewed Original Research
1994
Stochastic versus deterministic variability in simple neuronal circuits: II. Hippocampal slice
Schiff S, Jerger K, Chang T, Sauer T, Aitken P. Stochastic versus deterministic variability in simple neuronal circuits: II. Hippocampal slice. Biophysical Journal 1994, 67: 684-691. PMID: 7948681, PMCID: PMC1225410, DOI: 10.1016/s0006-3495(94)80527-2.Peer-Reviewed Original ResearchConceptsInput-output time seriesEvidence of determinismTime seriesNonlinear predictionDeterministic variabilitySimple neuronal circuitLong time seriesSurrogate dataPresynaptic volley amplitudeStatistical controlFlow approachDiscrete adaptationDispersion approachInput-output functionAmplitudeSingle instanceApproachControlling chaos in the brain
Schiff S, Jerger K, Duong D, Chang T, Spano M, Ditto W. Controlling chaos in the brain. Nature 1994, 370: 615-620. PMID: 8065447, DOI: 10.1038/370615a0.Peer-Reviewed Original Research
1987
The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra.
Schiff S, Somjen G. The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra. Stroke 1987, 18: 30-37. PMID: 3027927, DOI: 10.1161/01.str.18.1.30.Peer-Reviewed Original ResearchConceptsMild hypoxiaSynaptic transmissionModerate hypoxiaHippocampal slicesGrade of hypoxiaHypoxic brain tissueExtracellular DC potentialDegree of hypoxiaPosthypoxic hyperexcitabilityIschemic penumbraExtracellular calciumExtracellular potassiumSynaptic functionBrain tissueHypoxiaHyperexcitabilityExtracellular pHSlicesSevere depolarizationNeuronsDC potentialResponse
1986
Barbiturate protection against hypoxic neuronal damage in vitro.
Aitken P, Schiff S. Barbiturate protection against hypoxic neuronal damage in vitro. Journal Of Neurosurgery 1986, 65: 230-2. PMID: 3723181, DOI: 10.3171/jns.1986.65.2.0230.Peer-Reviewed Original ResearchSelective neuronal vulnerability to hypoxia in vitro
Aitken P, Schiff S. Selective neuronal vulnerability to hypoxia in vitro. Neuroscience Letters 1986, 67: 92-96. PMID: 3014393, DOI: 10.1016/0304-3940(86)90215-6.Peer-Reviewed Original Research
1985
The effects of temperature on synaptic transmission in hippocampal tissue slices
Schiff S, Somjen G. The effects of temperature on synaptic transmission in hippocampal tissue slices. Brain Research 1985, 345: 279-284. PMID: 2994845, DOI: 10.1016/0006-8993(85)91004-2.Peer-Reviewed Original Research