2019
The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial.
Punchak M, Mbabazi Kabachelor E, Ogwal M, Nalule E, Nalwoga J, Ssenyonga P, Mugamba J, Rattani A, Dewan M, Kulkarni A, Schiff S, Warf B. The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial. Neurosurgery 2019, 85: e714-e721. PMID: 31086941, PMCID: PMC7534394, DOI: 10.1093/neuros/nyz122.Peer-Reviewed Original ResearchConceptsChoroid plexus cauterizationETV/CPCPostoperative seizure incidencePostinfectious hydrocephalusSeizure incidenceEndoscopic third ventriculostomyUgandan infantsShunt placementMantel-Haenszel hazard ratiosKaplan-Meier methodVentriculoperitoneal shunt placementPostoperative epilepsyPostoperative seizuresPreoperative symptomsEpilepsy incidenceFirst seizureHazard ratioControlled TrialsEndoscopic treatmentThird ventriculostomyTreatment modalitiesSeizure riskHead circumferenceRelative riskSeizure onset
2011
Costs and benefits of neurosurgical intervention for infant hydrocephalus in sub-Saharan Africa.
Warf B, Alkire B, Bhai S, Hughes C, Schiff S, Vincent J, Meara J. Costs and benefits of neurosurgical intervention for infant hydrocephalus in sub-Saharan Africa. Journal Of Neurosurgery Pediatrics 2011, 8: 509-21. PMID: 22044378, DOI: 10.3171/2011.8.peds11163.Peer-Reviewed Original ResearchConceptsBenefit-cost ratioDisability-adjusted life yearsHuman capital approachEconomic benefitsNeurosurgical interventionCapital approachCost/disability-adjusted life yearStatistical life approachFavorable benefit-cost ratioTotal economic benefitPotential economic impactMajor public health priorityEndoscopic third ventriculostomyBenefits of treatmentCases of hydrocephalusVSL approachPublic health priorityEconomic modelingCURE Children's HospitalTreatment of hydrocephalusEconomic impactLife yearsUntreated hydrocephalusRetrospective reviewShunt placementFive-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants.
Warf B, Dagi A, Kaaya B, Schiff S. Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants. Journal Of Neurosurgery Pediatrics 2011, 8: 502-8. PMID: 22044377, DOI: 10.3171/2011.8.peds11221.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusFive-year survivalShunt placementPrimary brain injuryWorse functional outcomeKaplan-Meier methodLong-term outcomesLog-rank testOutcome of treatmentEndoscopic third ventriculostomyTreatment selection biasPublic health measuresOne-thirdUgandan infantsWorst sequelaeOperative mortalityNeonatal infectionFunctional outcomeThird ventriculostomyBrain injuryPrimary treatmentCommon causeInfant hydrocephalusSurvival advantageOriginal infection
2000
Long-Term Follow-Up Data from the Shunt Design Trial
Kestle J, Drake J, Milner R, Sainte-Rose C, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Long-Term Follow-Up Data from the Shunt Design Trial. Pediatric Neurosurgery 2000, 33: 230-236. PMID: 11155058, DOI: 10.1159/000055960.Peer-Reviewed Original ResearchConceptsFirst shunt failureShunt failureDifferential pressure valvesOverall shunt survivalShunt Design TrialShunt failure ratesLate complicationsShunt surgeryShunt survivalInitial treatmentTerm followShunt obstructionDelta valvesHydrocephalic childrenOriginal trialPediatric hydrocephalusSurvival advantagePatient statusPatientsTrialsDesign trialSignificant differencesObstructionOverdrainageInfection
1998
Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus.
Drake J, Kestle J, Milner R, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurgery 1998, 43: 294-303; discussion 303-5. PMID: 9696082, DOI: 10.1097/00006123-199808000-00068.Peer-Reviewed Original ResearchConceptsShunt obstructionDifferential pressure valvesShunt failurePediatric hydrocephalusCerebrospinal fluid shunt failuresCerebrospinal fluid shunt insertionTreatment failure rateShunt failure ratesOrbis-Sigma valvePediatric neurosurgical centersUpright positionCerebrospinal fluid shuntsIndependent case reviewShunt insertionCerebral ventricleDelta valvesHydrocephalic childrenFailure rateNeurosurgical centersOutcome eventsCase reviewPatientsObstructionShunt valveInfection
1994
Seizure control following tumor surgery for childhood cortical low-grade gliomas.
Packer R, Sutton L, Patel K, Duhaime A, Schiff S, Weinstein S, Gaillard W, Conry J, Schut L. Seizure control following tumor surgery for childhood cortical low-grade gliomas. Journal Of Neurosurgery 1994, 80: 998-1003. PMID: 8189281, DOI: 10.3171/jns.1994.80.6.0998.Peer-Reviewed Original ResearchConceptsSeizure controlPoor seizure controlLow-grade gliomasElectrocortical mappingSeizure focusTumor resectionTumor surgeryEEG monitoringLong-term seizure controlLow-grade glial tumorsPartial tumor resectionGood seizure controlHistory of seizuresExtensive tumor resectionLow-grade neoplasmsMajority of childrenCortical tumorsSeizure outcomeSurgical resectionPartial resectionTumor locationTumor removalGlial tumorsHigh riskResection