2022
Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus
Hehnly C, Shi A, Ssentongo P, Zhang L, Isaacs A, Morton S, Streck N, Erdmann-Gilmore P, Tolstoy I, Townsend R, Limbrick D, Paulson J, Ericson J, Galperin M, Schiff S, Broach J. Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus. MBio 2022, 13: e02688-22. PMID: 36374038, PMCID: PMC9765702, DOI: 10.1128/mbio.02688-22.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusClinical isolatesVirulence factorsCritical virulence factorPotential virulence factorsPoor long-term outcomesPrevention of hydrocephalusLong-term outcomesBacterial pathogensDevastating sequelaeNeonatal sepsisMiddle-income countriesNeonatal infectionSurgical interventionReference strainsNovel bacterial pathogensAfrican cohortBeta-lactamase genesChildhood mortalityHydrocephalusTherapeutic targetInfectionVirulent strainDevastating diseaseWhole-genome sequencing
1995
FDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery,evaluation
Gaillard W, White S, MalOw B, Flamini R, Weinstein S, Sato S, Kufta C, Schiff S, Devinsky O, Fazilat S, Reeves P, Theodore W. FDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery,evaluation. Epilepsy Research 1995, 20: 77-84. PMID: 7713062, DOI: 10.1016/0920-1211(94)00065-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociPartial seizuresFDG-PETEpileptic focusGlucose metabolismRefractory complex partial epilepsyFocal MRI abnormalitiesInterictal glucose metabolismUnilateral EEG focusFDG-PET resultsFDG-PET hypometabolismComplex partial epilepsyFocal hypometabolismPET hypometabolismMRI abnormalitiesMetabolic abnormalitiesEpilepsy surgerySurgical interventionPartial epilepsyVideo-EEGEpileptogenic zonePoor responseRegional hypometabolismDrug treatment