2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell typesModulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel role
2008
30 Towards a Dynamics of Seizure Mechanics
Schiff S, Cressman J, Barreto E, Žiburkus J. 30 Towards a Dynamics of Seizure Mechanics. 2008, 496-xviii. DOI: 10.1016/b978-012373649-9.50033-8.Peer-Reviewed Original ResearchDepolarization blockRelevant neuronal subtypesExcitatory principal cellsHippocampal seizuresGap junction connectivityPyramidal cellsHuman epilepsyInhibitory interneuronsIntracellular recordingsSynaptic currentsNeuronal subtypesHuman seizuresSeizuresInterneuronsPrincipal cellsSeizure dynamicsTime courseSynchrony featuresNeuronal dynamicsCellsEpilepsy
2006
Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events
Ziburkus J, Cressman J, Barreto E, Schiff S. Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events. Journal Of Neurophysiology 2006, 95: 3948-3954. PMID: 16554499, PMCID: PMC1469233, DOI: 10.1152/jn.01378.2005.Peer-Reviewed Original Research
1988
Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices
Schiff S, Somjen G. Reversible Synaptic Blockade Caused by Hypoxia of Moderate Degree in Hippocampal Tissues Slices. Advances In Behavioral Biology 1988, 35: 175-182. DOI: 10.1007/978-1-4684-5562-5_20.Peer-Reviewed Original ResearchArtificial cerebrospinal fluidHypoxic episodesIschemic brain infarctsModerate hypoxic episodesOrthodromic population spikesReversible synaptic blockadeExcitatory postsynaptic potentialsInterstitial potassium concentrationAfferent fiber volleysHippocampal tissue slicesImpairment of membraneTissue slicesPosthypoxic hyperexcitabilityBrain infarctsSynaptic blockadePopulation spikesReadmission of oxygenFiber volleyPostsynaptic potentialsCA1 regionPyramidal cellsRat hippocampusSynaptic transmissionCerebrospinal fluidCalcium levels
1986
Barbiturate protection against hypoxic neuronal damage in vitro.
Aitken P, Schiff S. Barbiturate protection against hypoxic neuronal damage in vitro. Journal Of Neurosurgery 1986, 65: 230-2. PMID: 3723181, DOI: 10.3171/jns.1986.65.2.0230.Peer-Reviewed Original Research
1985
Hyperexcitability following moderate hypoxia in hippocampal tissue slices
Schiff S, Somjen G. Hyperexcitability following moderate hypoxia in hippocampal tissue slices. Brain Research 1985, 337: 337-340. PMID: 2992681, DOI: 10.1016/0006-8993(85)90071-x.Peer-Reviewed Original Research