2015
Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, De Camilli P. Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. Journal Of Cell Biology 2015, 209: 85-95. PMID: 25869668, PMCID: PMC4395491, DOI: 10.1083/jcb.201409064.Peer-Reviewed Original ResearchConceptsEndocytic membranesPosition of inositolRecruitment of inositolSAC domainEndocytic pathwayPlasma membraneINPP5FSequential dephosphorylationOCRLDephosphorylationEndocytosisSynaptojaninRab5EndosomesYeastInositolMembranePhosphataseMacropinosomesClathrinCoimmunoprecipitationPtdInsPhosphoinositideVesiclesPathway
2014
Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B
Stagi M, Klein ZA, Gould TJ, Bewersdorf J, Strittmatter SM. Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B. Molecular And Cellular Neuroscience 2014, 61: 226-240. PMID: 25066864, PMCID: PMC4145808, DOI: 10.1016/j.mcn.2014.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCells, CulturedChlorocebus aethiopsEmbryo, MammalianGreen Fluorescent ProteinsHumansLuminescent ProteinsLysosomal-Associated Membrane Protein 1LysosomesMembrane ProteinsMiceMice, Inbred C57BLMicrotubule-Associated ProteinsNerve Tissue ProteinsProtein TransportRNA, MessengerRNA, Small InterferingStress, PhysiologicalTransfection
2012
Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes
Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S. Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes. Journal Of Neuroscience 2012, 32: 14080-14086. PMID: 23055476, PMCID: PMC3576841, DOI: 10.1523/jneurosci.3359-12.2012.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorType 2 diabetes mellitusNeurotrophic signaling pathwaysFrontotemporal lobar degenerationNon-neuronal cellsPathogenesis of neurodegenerationGenetic risk factorsBDNF levelsDiabetes mellitusFamily of receptorsNeurotrophic factorRisk factorsParkinson's diseaseTrk receptorsAcute responseAutosomal dominant formAlzheimer's diseaseNeurodegenerative diseasesDiseaseCell surface receptorsReceptorsSignaling pathwaysSurface receptorsPleiotropic functionsIntracellular responses