2016
Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles
Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J. Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Nanomedicine Nanotechnology Biology And Medicine 2016, 12: 1833-1842. PMID: 27039220, PMCID: PMC5045320, DOI: 10.1016/j.nano.2016.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A2 Receptor AgonistsAnimalsBlood-Brain BarrierBrain IschemiaDrug Delivery SystemsHumansMaleMice, Inbred C57BLNanoparticlesPurinesPyrazolesStrokeConceptsDrug deliveryTargeted Drug DeliveryIschemic strokeNanoparticlesDelivery efficiencyTargeting approachesIschemic microenvironmentBlood-brain barrier permeabilityBlood-brain barrierCurrent drug treatmentPotential therapeutic agentPromising strategyInfarct volumeNEP1-40Clinical managementLeading causeBarrier permeabilitySubsequent administrationDrug treatmentStrokeTherapeutic agentsEnhanced survivalDeliveryEfficiencyMicroenvironment
2003
Targeting the Nogo Receptor to Treat Central Nervous System Injuries
Lee DH, Strittmatter SM, Sah DW. Targeting the Nogo Receptor to Treat Central Nervous System Injuries. Nature Reviews Drug Discovery 2003, 2: 872-879. PMID: 14668808, DOI: 10.1038/nrd1228.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InjuriesDrug Delivery SystemsHumansNerve RegenerationReceptors, Cell SurfaceSpinal Cord InjuriesConceptsCentral nervous systemAxonal regrowthNogo receptorCentral nervous system injuryNovel drug discovery strategyCNS myelinNervous system injurySpinal cord injuryTraumatic head injuryLarge unmet needOligodendrocyte myelin glycoproteinAxonal damageSystem injuryCNS injuryCord injuryAxonal regenerationHead injuryCNS neuronsGrowth cone collapseSuch injuriesAxon regrowthNervous systemUnmet needDrug discovery strategiesInjury