2019
Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma
Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM. Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma. Journal Of Neuroscience 2019, 39: 3204-3216. PMID: 30804090, PMCID: PMC6788813, DOI: 10.1523/jneurosci.2996-18.2019.Peer-Reviewed Original ResearchConceptsCNS traumaNeural repairMouse cervical spinal cordSpinal cord traumaCervical spinal cordNon-neuronal cellsInteraction of NogoAxon growth inhibitionAxonal guidance mechanismsNeurological recoveryAxonal sproutingCNS pathwaysCord traumaFunctional recoveryAxon sproutingSpinal cordNgR1 functionUnilateral pyramidotomyAxon regenerationAdult traumaNgR1TraumaAxon growthNogoCytoplasmic mediators
2012
PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition
Shim SO, Cafferty WB, Schmidt EC, Kim BG, Fujisawa H, Strittmatter SM. PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Molecular And Cellular Neuroscience 2012, 50: 193-200. PMID: 22564823, PMCID: PMC3383336, DOI: 10.1016/j.mcn.2012.04.007.Peer-Reviewed Original ResearchConceptsAxonal growthSpinal cordPellet retrieval taskCervical spinal cordWild-type miceContralateral gray matterAxon guidance cuesSevered fibersSprouted fibersAxonal sproutingCorticofugal projectionsFunctional recoveryBehavioral recoveryCNS injuryImpaired forelimbClass 3 semaphorinsCorticospinal fibersCorticospinal tractMedullary pyramidsSynaptic punctaInhibitor receptorsType miceUnilateral pyramidotomyNeuron inhibitionAdult trauma
2006
The Nogo–Nogo Receptor Pathway Limits a Spectrum of Adult CNS Axonal Growth
Cafferty WB, Strittmatter SM. The Nogo–Nogo Receptor Pathway Limits a Spectrum of Adult CNS Axonal Growth. Journal Of Neuroscience 2006, 26: 12242-12250. PMID: 17122049, PMCID: PMC2848954, DOI: 10.1523/jneurosci.3827-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAxonsBehavior, AnimalCalcitonin Gene-Related PeptideCentral Nervous SystemFunctional LateralityGlial Fibrillary Acidic ProteinMiceMice, Inbred C57BLMice, KnockoutMyelin Basic ProteinMyelin ProteinsNogo ProteinsProtein Kinase CPsychomotor PerformancePyramidal TractsReceptors, PeptideSignal TransductionConceptsAxonal growthCST regenerationSpinal cord dorsal hemisectionCervical gray matterRole of NogoCorticospinal tract axonsNogo-66 receptorVivo pharmacological studiesFine motor skillsDorsal hemisectionAffected forelimbCST axonsLesion modelUnilateral pyramidotomyGray matterPharmacological studiesReceptor pathwayNogoConflicting resultsMiceMotor skillsAxonsDifferent tractsGenetic assessmentPyramidotomy