2019
Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma
Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM. Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma. Journal Of Neuroscience 2019, 39: 3204-3216. PMID: 30804090, PMCID: PMC6788813, DOI: 10.1523/jneurosci.2996-18.2019.Peer-Reviewed Original ResearchConceptsCNS traumaNeural repairMouse cervical spinal cordSpinal cord traumaCervical spinal cordNon-neuronal cellsInteraction of NogoAxon growth inhibitionAxonal guidance mechanismsNeurological recoveryAxonal sproutingCNS pathwaysCord traumaFunctional recoveryAxon sproutingSpinal cordNgR1 functionUnilateral pyramidotomyAxon regenerationAdult traumaNgR1TraumaAxon growthNogoCytoplasmic mediators
2015
Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood
Bhagat SM, Butler SS, Taylor JR, McEwen BS, Strittmatter SM. Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood. Molecular Psychiatry 2015, 21: 1281-1289. PMID: 26619810, PMCID: PMC4887429, DOI: 10.1038/mp.2015.179.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderExtinction trainingFear memorySpontaneous fear recoveryBasolateral amygdalaJuvenile rodentsFear recoveryFear renewalFear extinctionFear expressionInhibitory synapse markersNgR1 expressionStress disorderNogo receptor 1Anxiety disordersInfralimbic cortexCritical periodNeural plasticityMemoryTemporary windowsReceptor 1TrainingAdulthoodNgR1 functionNaive mice