2006
Extracellular regulators of axonal growth in the adult central nervous system
Liu BP, Cafferty WB, Budel SO, Strittmatter SM. Extracellular regulators of axonal growth in the adult central nervous system. Philosophical Transactions Of The Royal Society B Biological Sciences 2006, 361: 1593-1610. PMID: 16939977, PMCID: PMC1664666, DOI: 10.1098/rstb.2006.1891.Peer-Reviewed Original ResearchConceptsAxonal growth inhibitorsAxonal sproutingCNS injuryAdult CNSAxonal growthAdult central nervous systemAdult CNS injuryCentral nervous system functionRecovery of functionRobust axonal growthAstroglial scar formationAdult CNS axonsCentral nervous systemOligodendrocyte myelin glycoproteinNervous system functionNeurological functionPathological damageAxonal stabilityNervous systemScar formationAxonal receptorsNeuronal connectivityCNS axonsEphrin-B3Such interventionsAlzheimer Precursor Protein Interaction with the Nogo-66 Receptor Reduces Amyloid-β Plaque Deposition
Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W, Lee DH, Strittmatter SM. Alzheimer Precursor Protein Interaction with the Nogo-66 Receptor Reduces Amyloid-β Plaque Deposition. Journal Of Neuroscience 2006, 26: 1386-1395. PMID: 16452662, PMCID: PMC2846286, DOI: 10.1523/jneurosci.3291-05.2006.Peer-Reviewed Original ResearchConceptsAmyloid precursor proteinAlzheimer's diseaseAbeta levelsDystrophic neuritesPlaque depositionAmyloid-β plaque depositionCourse of ADAbeta plaque depositionTransgenic AD modelBrain Abeta levelsAD brain samplesAdult CNS axonsAxonal sprouting responseNgR expressionAbeta depositsAxonal dysfunctionPathophysiologic hypothesesSecretase processingTraumatic injuryAbeta productionDisease processAD modelBrain samplesCNS axonsPlaque deposits
2001
Nogo: A Molecular Determinant of Axonal Growth and Regeneration
Grandpré T, Strittmatter S. Nogo: A Molecular Determinant of Axonal Growth and Regeneration. The Neuroscientist 2001, 7: 377-386. PMID: 11597097, DOI: 10.1177/107385840100700507.Peer-Reviewed Original ResearchConceptsCentral nervous systemCNS environmentNervous systemAdult mammalian central nervous systemEnhanced axonal regenerationPersistent functional deficitsMammalian central nervous systemPeripheral nervous systemNeurite outgrowth inhibitorIntegral membrane proteinsCNS traumaFunctional recoveryReactive astrocytesVivo neutralizationCNS injuryAxonal regenerationFunctional deficitsGlial scarNonpermissive natureOutgrowth inhibitorCNS axonsAxonal growthAxonal elongationMembrane proteinsAxon elongation
2000
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
GrandPré T, Nakamura F, Vartanian T, Strittmatter S. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000, 403: 439-444. PMID: 10667797, DOI: 10.1038/35000226.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsCattleCell DivisionCell LineCentral Nervous SystemChick EmbryoCloning, MolecularConsensus SequenceEscherichia coliGrowth InhibitorsHumansMembrane ProteinsMolecular Sequence DataMyelin ProteinsNerve RegenerationNogo ProteinsOligodendrogliaPC12 CellsRatsRecombinant ProteinsSequence Homology, Amino AcidConceptsCentral nervous systemPeripheral nervous systemCNS white matterAxonal regenerationAxon regenerationNervous systemWhite matterAdult central nervous systemMammalian axon regenerationIN-1 antibodiesReticulon 1Dorsal root ganglion growth conesFunctional recoverySpinal cordSchwann cellsCNS axonsExtracellular domainAxonal extensionNogoAxon extensionGrowth conesOligodendrocytesInhibitory activityReticulon 4Moderate degree