2009
In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome
Ha AC, Renaud JM, deKemp RA, Thorn S, DaSilva J, Garrard L, Yoshinaga K, Abraham A, Green MS, Beanlands RS, Gollob MH. In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome. Circulation Cardiovascular Imaging 2009, 2: 485-491. PMID: 19920047, DOI: 10.1161/circimaging.109.853291.Peer-Reviewed Original ResearchMeSH KeywordsAdultAMP-Activated Protein KinasesCase-Control StudiesEchocardiographyFemaleFluorodeoxyglucose F18Heart DiseasesHumansMaleMetabolic DiseasesMiddle AgedMutationMyocardiumPhenotypeRadiographic Image Interpretation, Computer-AssistedRubidium RadioisotopesStatistics, NonparametricSyndromeTomography, Emission-ComputedConceptsMyocardial glucose uptakeSignificant myocardial scarFDG-PET imagingPRKAG2 cardiac syndromeCardiac syndromeGlucose uptakeAdult patientsMyocardial scarMetabolic diseasesControl groupMedian blood glucoseEuglycemic hyperinsulinemic clampStable blood glucose levelsBlood glucose levelsInherited metabolic diseaseMin/Positron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyMyocardial glucose transportPerfusion scanBlood glucoseControl subjectsHyperinsulinemic clampAffected patients
2005
Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders.
Yoshinaga K, Chow BJ, dekemp RA, Thorn S, Ruddy TD, Davies RA, DaSilva JN, Beanlands R. Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders. Current Pharmaceutical Design 2005, 11: 903-32. PMID: 15777243, DOI: 10.2174/1381612053381800.Peer-Reviewed Original ResearchConceptsVivo pharmacokinetic studyDrug deliveryMolecular probesCardiovascular diseaseEffect of therapyAccuracy of PETPET/CTNon-invasive imaging modalityEvaluation of drugsMolecular imagingPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyPotential of PETNon-invasive modalityMechanism of actionPharmacokinetic studyCardiac molecular imagingEarly drug developmentAdvantages of PETDrug therapyDisease progressionSerial evaluationDrug treatmentReceptor levels