2021
Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice
Lee SR, Thorn S, Guerrera N, Gonzalez L, Taniguchi R, Langford J, Sinusas AJ, Dardik A. Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice. JVS Vascular Science 2021, 2: 110-128. PMID: 34423320, PMCID: PMC8375600, DOI: 10.1016/j.jvssci.2021.05.002.Peer-Reviewed Original ResearchArteriovenous fistulaCardiac hypertrophyCardioprotective featuresRelative LV wall thicknessPoor cardiac outcomesRight heart functionSham-operated miceAdaptive cardiac hypertrophyLV wall thicknessSignificant sex-dependent differencesAreas of fibrosisInflammation-related genesPhysiologic cardiac hypertrophyCardiac chamber sizeCardiac fetal genesWild-type miceSex-dependent differencesSimilar body weightIngenuity Pathway AnalysisArrhythmogenic featuresAVF miceSerial echocardiographyCardiac outcomesDiastolic functionLV systolic
2009
Distinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial Glycogen
Folmes KD, Chan AY, Koonen DP, Pulinilkunnil TC, Baczkó I, Hunter BE, Thorn S, Allard MF, Roberts R, Gollob MH, Light PE, Dyck JR. Distinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial Glycogen. Circulation Genomic And Precision Medicine 2009, 2: 457-466. PMID: 20031621, DOI: 10.1161/circgenetics.108.834564.Peer-Reviewed Original ResearchConceptsTransgenic miceR302Q mutationGlycogen contentAcute expressionCardiomyocyte-restricted expressionAMPK activationTransgenic adult miceNeonatal rat cardiomyocytesChronic modelWolff-ParkinsonGlycogen synthase activityWhite syndromeCardiac hypertrophyAdult miceGlycogen storage cardiomyopathyMyocardial glycogenDirect effectCompensatory alterationsRat cardiomyocytesFamilial formsMiceEarly signaling eventCardiomyopathyAMPK activityHeart