2024
A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress
Fedeles B, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade D, Westergerling P, Staudner T, Campolo J, Liu S, Dong K, Cai Y, Rehman M, Gallagher A, Ruchirawat S, Croy R, Essigmann J, Fedeles S, Somlo S. A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317344121. PMID: 38241440, PMCID: PMC10823221, DOI: 10.1073/pnas.2317344121.Peer-Reviewed Original ResearchConceptsCyst cellsAutosomal dominant polycystic kidney diseaseMouse models of autosomal dominant polycystic kidney diseasePolycystic kidney diseaseModel of autosomal dominant polycystic kidney diseaseKidney diseaseDeveloped primersMitochondrial oxidative stressPathophysiology of autosomal dominant polycystic kidney diseaseOxidative stressInduce apoptosisMitochondrial respirationCystic cellsUp-regulating aerobic glycolysisHomozygous inactivationMonogenic causeDominant polycystic kidney diseaseAerobic glycolysisRenal replacement therapyApoptosisEnd-stage kidney diseaseAnti-tumor agentsAdult mouse modelChronic kidney diseaseAlkylate DNA
2012
Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation
Aguiari G, Bizzarri F, Bonon A, Mangolini A, Magri E, Pedriali M, Querzoli P, Somlo S, Harris PC, Catizone L, del Senno L. Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation. Journal Of Molecular Medicine 2012, 90: 1267-1282. PMID: 22570239, PMCID: PMC4028691, DOI: 10.1007/s00109-012-0902-3.Peer-Reviewed Original ResearchMeSH KeywordsAmphiregulinAnimalsCell ProliferationCyclic AMPCyclic AMP Response Element-Binding ProteinEGF Family of ProteinsGene SilencingGlycoproteinsHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsMiceMutagenesisMutationOligonucleotide Array Sequence AnalysisPhosphorylationPolycystic Kidney, Autosomal DominantPromoter Regions, GeneticSignal TransductionTranscription Factor AP-1TRPP Cation ChannelsConceptsActivator protein-1Cystic cellsCell proliferationFull-length PC1ADPKD cell proliferationCell growthEpidermal growth factor-like peptidesGrowth factor-like peptidesAutosomal dominant polycystic kidney diseaseRenal cyst developmentAbnormal cell proliferationChromatin immunoprecipitationPolycystin-1Key activatorEGFR activityMicroarray analysisAmphiregulin genesNew potential therapeutic targetsLuciferase assayFactor-like peptidesProtein 1Potential therapeutic targetCell linesAmphiregulin expressionCyst development