2017
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study
Holmes SE, Hinz R, Conen S, Gregory CJ, Matthews JC, Anton-Rodriguez JM, Gerhard A, Talbot PS. Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study. Biological Psychiatry 2017, 83: 61-69. PMID: 28939116, DOI: 10.1016/j.biopsych.2017.08.005.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexMajor depressive episodeMajor depressive disorderPositron emission tomographyTSPO availabilityDepressive episodeControl subjectsDepressive disorderTranslocator proteinPK11195 positron emission tomographySevere major depressive episodeEmission tomographySuicidal thinkingSuicidal thoughtsPrefrontal cortexInvolvement of inflammationPeripheral inflammatory markersPositron emission tomography studyAnti-inflammatory therapyHealthy control subjectsLeast moderate severityMedication-free patientsEmission tomography studiesTSPO-specific radioligandBrains of individuals
2016
In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study
Holmes SE, Hinz R, Drake RJ, Gregory CJ, Conen S, Matthews JC, Anton-Rodriguez JM, Gerhard A, Talbot PS. In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study. Molecular Psychiatry 2016, 21: 1672-1679. PMID: 27698434, DOI: 10.1038/mp.2016.180.Peer-Reviewed Original ResearchConceptsMedicated patientsTSPO availabilityMicroglial activationMicroglial activityNegative symptomsAntipsychotic-naive groupBrain microglial activityRegular intramuscular injectionsPositron emission tomography studySubset of patientsAnti-inflammatory statePrimary negative symptomsBrain of adultAntipsychotic-free patientsPathophysiology of schizophreniaPotential modulatory effectsEmission tomography studiesHealthy comparison subjectsTranslocator proteinNegative Syndrome ScaleEmission Tomography ImagingPositron emission tomography (PET) imagingParietal cortical regionsAntipsychotic medicationMedicated schizophrenia