In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study
Holmes SE, Hinz R, Drake RJ, Gregory CJ, Conen S, Matthews JC, Anton-Rodriguez JM, Gerhard A, Talbot PS. In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study. Molecular Psychiatry 2016, 21: 1672-1679. PMID: 27698434, DOI: 10.1038/mp.2016.180.Peer-Reviewed Original ResearchConceptsMedicated patientsTSPO availabilityMicroglial activationMicroglial activityNegative symptomsAntipsychotic-naive groupBrain microglial activityRegular intramuscular injectionsPositron emission tomography studySubset of patientsAnti-inflammatory statePrimary negative symptomsBrain of adultAntipsychotic-free patientsPathophysiology of schizophreniaPotential modulatory effectsEmission tomography studiesHealthy comparison subjectsTranslocator proteinNegative Syndrome ScaleEmission Tomography ImagingPositron emission tomography (PET) imagingParietal cortical regionsAntipsychotic medicationMedicated schizophrenia