Selective Depletion of Molecularly Defined Cortical Interneurons in Human Holoprosencephaly with Severe Striatal Hypoplasia
Fertuzinhos S, Krsnik Ž, Kawasawa YI, Rašin M, Kwan KY, Chen JG, Judaš M, Hayashi M, Šestan N. Selective Depletion of Molecularly Defined Cortical Interneurons in Human Holoprosencephaly with Severe Striatal Hypoplasia. Cerebral Cortex 2009, 19: 2196-2207. PMID: 19234067, PMCID: PMC2722430, DOI: 10.1093/cercor/bhp009.Peer-Reviewed Original ResearchConceptsCortical interneuronsProjection neuronsInterneuron subtypesDorsal forebrainNitric oxide synthase 1Ventral forebrainCortical interneuron diversityGlutamatergic projection neuronsHuman holoprosencephalyInhibitory GABAergic interneuronsCortex of controlCortical interneuron subtypesEarly fetal periodClinical manifestationsInfant casesNeuropeptide YGABAergic interneuronsNeuronal pathogenesisCalretinin expressionInterneuronsFetal periodDifferent subtypesSelective depletionInterneuron diversityForebrain