2024
Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter
Malamud J, Guloksuz S, van Winkel R, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Rutten B, Huys Q. Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter. PLOS Computational Biology 2024, 20: e1012457. PMID: 39312537, PMCID: PMC11449358, DOI: 10.1371/journal.pcbi.1012457.Peer-Reviewed Original ResearchConceptsEcological momentary assessmentEcological momentary assessment dataMood statesMood disordersDepressive stateMood dynamicsFeatures of mood disordersCombination of ecological momentary assessmentsControl of moodSymptoms of depressionInternal emotional statesAlterations to interactionsPsychopathological featuresMomentary assessmentMoodEmotional statesDepressionEnvironmental stimuli
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyCannabinoid Receptor AgonistsCannabisDepressionHumansLongitudinal StudiesPsychotic DisordersConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportLongitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy
Schurgers G, Walter S, Pishva E, Guloksuz S, Peerbooms O, Incio L, Arts B, Kenis G, Rutten B. Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy. European Neuropsychopharmacology 2022, 63: 60-70. PMID: 36067540, DOI: 10.1016/j.euroneuro.2022.07.183.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF/TrkBExpression of BDNFSerum BDNF protein levelsBDNF protein levelsElectroconvulsive therapyDepression scoresMRNA expressionPeripheral bloodTreatment-resistant depressed patientsProtein levelsMechanism of actionAntidepressant effectsNeurotrophic factorDepressed patientsLongitudinal alterationsSevere depressionBlood correlatesEffective treatmentLongitudinal changesTrkBStudy periodNR3C1PatientsTherapy
2021
Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: a prospective 6-year cohort study
de Boer N, Vermeulen J, Lin B, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Rutten B, Batalla A, Guloksuz S, Luykx J. Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: a prospective 6-year cohort study. Psychological Medicine 2021, 53: 1409-1417. PMID: 35023464, PMCID: PMC10009403, DOI: 10.1017/s0033291721002968.Peer-Reviewed Original ResearchConceptsNumber of cigarettesDepressive symptomsAlcohol useLongitudinal associationsGeneral populationSmoking behaviorAlcohol consumptionGenetic risk scoringSymptoms of depressionGenetic risk score analysisGenetic risk scoreAlcohol cessationCohort studySmoking statusGlobal burdenMood disordersRisk scoreSmokingModerate drinkingRisk score analysisLess symptomsLinear mixed effects modelsSymptomsScore analysisRisk scoring
2020
The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2
Rauschenberg C, Reininghaus U, Have M, de Graaf R, van Dorsselaer S, Simons C, Gunther N, Henquet C, Pries L, Guloksuz S, Bak M, van Os J. The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2. Psychological Medicine 2020, 51: 1696-1703. PMID: 32174291, PMCID: PMC8327623, DOI: 10.1017/s0033291720000446.Peer-Reviewed Original Research
2019
Toward incorporating genetic risk scores into symptom networks of psychosis
Isvoranu A, Guloksuz S, Epskamp S, van Os J, Borsboom D, Investigators. Toward incorporating genetic risk scores into symptom networks of psychosis. Psychological Medicine 2019, 50: 636-643. PMID: 30867074, PMCID: PMC7093319, DOI: 10.1017/s003329171900045x.Peer-Reviewed Original Research
2014
The Immune System and Electroconvulsive Therapy for Depression
Guloksuz S, Rutten B, Arts B, van Os J, Kenis G. The Immune System and Electroconvulsive Therapy for Depression. Journal Of Ect 2014, 30: 132-137. PMID: 24755720, DOI: 10.1097/yct.0000000000000127.Peer-Reviewed Original ResearchConceptsEffects of ECTElectroconvulsive therapyImmune systemMechanism of actionImmune activationImmune functioningImpact of ECTTherapeutic actionTreatment-resistant depressionTransient immune activationPubMed/MEDLINEPossible roleImmunological changesCytokine concentrationsAdrenal axisTreatment optionsLarger sample sizeTreatment resultsPsychiatric conditionsSingle sessionRelevant articlesDefinitive conclusionsSearch termsSample sizeDepressionClinical Features of Night Eating Syndrome among Depressed Patients
Kucukgoncu S, Tek C, Bestepe E, Musket C, Guloksuz S. Clinical Features of Night Eating Syndrome among Depressed Patients. European Eating Disorders Review 2014, 22: 102-108. PMID: 24436087, DOI: 10.1002/erv.2280.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxiety DisordersBody Mass IndexCircadian RhythmDepressionFeeding and Eating DisordersFeeding BehaviorFemaleHumansInterviews as TopicMaleMiddle AgedObesityPersonality InventoryPrevalencePsychiatric Status Rating ScalesQuality of LifeRegression AnalysisSocioeconomic FactorsStress, PsychologicalSurveys and QuestionnairesSyndromeYoung AdultConceptsPittsburgh Sleep Quality IndexBeck Depression InventoryBeck Anxiety InventoryClinical featuresDepressed patientsDepression InventoryNon-NE patientsNight eating syndromeSleep Quality IndexSample of patientsAnxiety InventorySeverity of anxietyNight Eating QuestionnaireSocio-demographic formSmoking statusDaytime dysfunctionSleep qualityDepressed outpatientsPatientsSyndromeEating QuestionnaireStudy sampleBMISignificant differencesDepression
2013
Depressive Symptoms in Crohn's Disease: Relationship with Immune Activation and Tryptophan Availability
Guloksuz S, Wichers M, Kenis G, Russel M, Wauters A, Verkerk R, Arts B, van Os J. Depressive Symptoms in Crohn's Disease: Relationship with Immune Activation and Tryptophan Availability. PLOS ONE 2013, 8: e60435. PMID: 23544139, PMCID: PMC3609785, DOI: 10.1371/journal.pone.0060435.Peer-Reviewed Original ResearchConceptsCrohn's diseaseDisease activityImmune activationDepressive symptomsDepression scoresTrp availabilityΑ treatmentTryptophan availabilityNegative APPsAnti-tumor necrosis factorPast depressive disorderTNF-α treatmentSymptoms of depressionQuality of lifeCD patientsIBDQ scoreImmune markersComorbid depressionDepressive disorderNecrosis factorInflammatory reactionPatientsSymptomsDiseaseTreatment