2023
Longitudinal effects of genomic and exposomic vulnerability for schizophrenia on childhood psychosis expression: results from the ABCD Study
Di Vincenzo M, Prachason T, Sampogna G, Arias-Magnasco A, Lin B, Pries L, Van Os J, Rutten B, Guloksuz S. Longitudinal effects of genomic and exposomic vulnerability for schizophrenia on childhood psychosis expression: results from the ABCD Study. Neuroscience Applied 2023, 2: 102518. DOI: 10.1016/j.nsa.2023.102518.Peer-Reviewed Original Research
2022
Gender differences in the association between environment and psychosis
Pence AY, Pries LK, Ferrara M, Rutten BPF, van Os J, Guloksuz S. Gender differences in the association between environment and psychosis. Schizophrenia Research 2022, 243: 120-137. PMID: 35287098, DOI: 10.1016/j.schres.2022.02.039.Peer-Reviewed Original ResearchConceptsGender-related differencesChildhood adversityPsychosis riskSubstance useSubstance abuse comorbidityEnvironmental exposuresOnset of illnessAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthPsychosis spectrum disordersHigh prevalencePsychotic disordersPubMed databaseSystematic reviewPsychosisWomenChildhood abuseSymptom dimensionsMenEarly ageAssociationPsychosis expressionFurther investigation
2020
Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
Pries L, Klingenberg B, Menne‐Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Cinar O, Lin B, Luykx J, Rutten B, van Os J, Guloksuz S. Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness. Acta Psychiatrica Scandinavica 2020, 141: 465-475. PMID: 32027017, PMCID: PMC7318228, DOI: 10.1111/acps.13158.Peer-Reviewed Original ResearchConceptsDaily life stressorsChildhood adversityEmotion dysregulationPositive affectPsychosis pronenessMomentary mental statesEcological momentary assessmentChildhood Trauma QuestionnaireGene-environment correlationNegative affectMental statesMomentary assessmentPsychosis expressionTrauma QuestionnaireAdversityAffectYoung adultsStressorsNovel evidencePolygenic liabilityInteraction effectsPronenessSchizophreniaHigh PRSState domain
2019
Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms
Pinckaers F, Rotee I, Nwosu C, Krolinski P, Smeets A, Gülöksüz S, de Jong L, Vaessen T, Damen T, Uittenboogaard A, Schäfer A, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Rutten B, van Os J, Drukker M. Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 1045-1054. PMID: 31209522, DOI: 10.1007/s00127-019-01711-z.Peer-Reviewed Original ResearchConceptsChildhood traumaGenetic liabilityImpact of CTSymptom Checklist-90 scoresMixed-effects linear regression analysisSubthreshold psychotic experiencesChildhood Trauma Questionnaire-Short FormExpression of psychosisGeneral population twinsQuestionnaire-Short FormPsychosis expressionMultilevel mixed-effects linear regression analysesRisk factorsPsychotic symptomsSymptom subscalesLinear regression analysisSubthreshold expressionTotal scoreStatistical significancePsychic Experience (CAPE) questionnaireRegression analysis