2017
Diverse Class 2 CRISPR-Cas Effector Proteins for Genome Engineering Applications
Pyzocha NK, Chen S. Diverse Class 2 CRISPR-Cas Effector Proteins for Genome Engineering Applications. ACS Chemical Biology 2017, 13: 347-356. PMID: 29121460, PMCID: PMC6768076, DOI: 10.1021/acschembio.7b00800.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial ProteinsCRISPR-Associated ProteinsCRISPR-Cas SystemsEndonucleasesGene EditingGenomeHumansRNA, Guide, CRISPR-Cas SystemsConceptsGenome engineering applicationsCRISPR-Cas genome editing technologiesMicrobial adaptive immune systemGenome editing technologyEffector enzymeNucleic acid cleavageEditing technologyUnique propertiesModern molecular biologyEngineering applicationsEffector proteinsMammalian cellsMolecular biologyAdaptive immune systemWide diversityTechnologyEnzymeApplicationsFunctionalityAcid cleavageImmune systemBiologyProteinDNADiversity
2014
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology 2014, 32: 551-553. PMID: 24681508, PMCID: PMC4157757, DOI: 10.1038/nbt.2884.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCRISPR-Associated ProteinsCRISPR-Cas SystemsGene EditingGenetic TherapyGenomeHydrolasesMiceMice, TransgenicMutationPhenotypeTreatment OutcomeTyrosinemias