1990
RAS gene product expression in blood and marrow smears of patients with acute leukemia: Importance of fixation
Needleman S, Cimino E, Mane S, Gutheil J, Kapil V, Chana G. RAS gene product expression in blood and marrow smears of patients with acute leukemia: Importance of fixation. Pathology 1990, 22: 77-81. PMID: 2235101, DOI: 10.3109/00313029009063784.Peer-Reviewed Original ResearchConceptsAcute non-lymphoblastic leukemiaP21 expressionAcute leukemiaMarrow aspiratesNon-lymphoblastic leukemiaNon-malignant diseasesHigh p21 expressionRas p21 expressionHistologic anaplasiaMost patientsRegional lymphLeukemic blastsProstate cancerBreast cancerGene product expressionPlasma cellsMarrow smearsNormal volunteersBlast cellsPatientsMyeloid cellsCodon 12Importance of fixationBlood smearsHuman malignancies
1989
c-myc amplification coexistent with activating N-ras point mutation in the biphenotypic leukemic cell line RED-3.
Mallet M, Mane S, Meltzer S, Needleman S. c-myc amplification coexistent with activating N-ras point mutation in the biphenotypic leukemic cell line RED-3. Leukemia 1989, 3: 511-5. PMID: 2659902.Peer-Reviewed Original ResearchConceptsCell linesMYC activationAcute myelogenous leukemiaN-ras point mutationsActivating point mutationC-MycN-rasAML patientsAcute leukemiaHL-60AML cellsMyelogenous leukemiaAggressive acute leukemiasLineage infidelityHuman tumorsDerivative cell linesPoint mutationsPatientsLeukemiaActivationSmall proportionCellsRed 3Protooncogene cMalignancy