2021
Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19
Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBlack or African AmericanCohort StudiesComorbidityCOVID-19CreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHispanic or LatinoHumansHypertensionKidney Function TestsLongitudinal StudiesMaleMiddle AgedPatient DischargeProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesSARS-CoV-2United StatesConceptsCOVID-19-associated acute kidney injuryAcute kidney injuryHospital acute kidney injurySubgroup of patientsKidney functionKidney injuryCohort studyHospital dischargeAKI recoveryKidney diseaseCOVID-19Peak creatinine levelsRetrospective cohort studyChronic kidney diseaseDays of dischargeHalf of patientsGlomerular filtration rateCoronavirus disease 2019AKI severityBaseline comorbiditiesEGFR decreaseDialysis requirementEGFR slopeKidney recoveryCreatinine levels
2020
Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept
Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.Peer-Reviewed Original ResearchConceptsAKI alertsHospitalized adultsKidney injuryUrban tertiary care hospitalAcute kidney injurySerum creatinine levelsObservational cohort studyTertiary care hospitalSerum creatinine concentrationBeats/minElectronic health recordsAKI diagnosisCohort studyCreatinine levelsInpatient mortalitySystolic bloodFractional excretionCenter studyBlood biomarkersUnivariable associationsUrine microscopyCreatinine concentrationClinical careElevated riskUrea nitrogenUrine Injury Biomarkers Are Not Associated With Kidney Transplant Failure.
Koyawala N, Reese PP, Hall IE, Jia Y, Thiessen-Philbrook HR, Mansour SG, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Urine Injury Biomarkers Are Not Associated With Kidney Transplant Failure. Transplantation 2020, 104: 1272-1279. PMID: 31568213, PMCID: PMC7384615, DOI: 10.1097/tp.0000000000002948.Peer-Reviewed Original ResearchConceptsAcute kidney injuryDonor Acute Kidney InjuryGraft failureInjury biomarkersSerum creatinineGraft outcomeKidney injuryComposite outcomeDeath-censored graft failureRisk of GFKidney injury molecule-1Cox proportional hazards modelLiver-type fatty acidSimilar allograft survivalStructural kidney damageKidney transplant recipientsInjury molecule-1Kidney transplant failureGlomerular filtration rateProportional hazards modelAKI kidneysAllograft survivalTransplant recipientsChart reviewNeutrophil gelatinase
2018
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Hall IE, Akalin E, Bromberg JS, Doshi MD, Greene T, Harhay MN, Jia Y, Mansour SG, Mohan S, Muthukumar T, Reese PP, Schröppel B, Singh P, Thiessen-Philbrook HR, Weng FL, Parikh CR. Deceased-donor acute kidney injury is not associated with kidney allograft failure. Kidney International 2018, 95: 199-209. PMID: 30470437, PMCID: PMC6331055, DOI: 10.1016/j.kint.2018.08.047.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryCause graft failureGraft survivalGraft failureGraft functionKidney injuryComposite outcomeDeceased donorsDonor-recipient gender combinationsLong-term allograft survivalKidney Donor Profile IndexDonor AKI stageExpanded-criteria donationKidney allograft failureUtilization of kidneysGlomerular filtration rateCold ischemia timePre-specified variablesKidney machine perfusionAKI stageAllograft failureAllograft survivalCardiac deathIschemia time