Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia
Romanello KS, Teixeira KKL, Silva JPMO, Nagamatsu ST, Bezerra MAC, Domingos IF, Martins DAP, Araujo AS, Lanaro C, Breyer CA, Ferreira RA, Franco-Penteado C, Costa FF, Malavazi I, Netto LES, de Oliveira MA, Cunha AF. Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia. PLOS ONE 2018, 13: e0208316. PMID: 30521599, PMCID: PMC6283586, DOI: 10.1371/journal.pone.0208316.Peer-Reviewed Original ResearchConceptsMolecular chaperone activityRed blood cellsCell redox statusLevels of transcriptsAntioxidant enzymesSevere oxidative damageBTI patientsBeta-thalassemia intermediaChaperone activityGlobal analysisTranscription factorsProtein contentAbundant proteinsOverall abundanceExpression profilesHigh hydroperoxide concentrationsLevels of ROSPrdx-1Red cell disordersBeta thalassemia