2024
Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study
Su J, Yeo Y, Jeetoo M, Morojele N, Francis J, Shenoi S, Braithwaite R. Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study. BMC Medicine 2024, 22: 481. PMID: 39428460, PMCID: PMC11492560, DOI: 10.1186/s12916-024-03674-8.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyBackgroundAlcohol use disorderTreating alcohol useCompared to baselineLong-acting PrEPDepressive disorderTreat AUDUse disorderMDDMDD screeningAlcohol usePHQ-9Quality-adjusted life yearsAUDCost-effectiveness of screeningSub-Saharan African settingDisordersImpact of screeningIntervention costsHIV infectionHIV transmissionHIV reductionInterventionHIV outcomesHIV epidemicConsiderations when prescribing opioid agonist therapies for people living with HIV
Tarfa A, Lier A, Shenoi S, Springer S. Considerations when prescribing opioid agonist therapies for people living with HIV. Expert Review Of Clinical Pharmacology 2024, 17: 549-564. PMID: 38946101, PMCID: PMC11299801, DOI: 10.1080/17512433.2024.2375448.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidAnti-HIV AgentsBuprenorphineDelayed-Action PreparationsDelivery of Health CareDrug InteractionsHealth Services AccessibilityHIV InfectionsHumansMethadoneNaltrexoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPre-Exposure ProphylaxisUnited StatesConceptsOpioid agonist therapyOpioid use disorderAntiretroviral therapyAgonist therapyDiagnosed OUDOpioid use disorder managementUse disorderTreatment of opioid use disorderExtended-release naltrexonePotential drug interactionsOpioid use disorder treatmentPrescribed opioid agonist therapyLong-acting formulationPre-exposure prophylaxisOUD outcomesImprove HIV preventionIntersection of HIVOpioid antagonistHIV outcomesHIV epidemicOpioidHIVOpioid use disorder servicesPWHHIV prevention
2023
Integrated Care Models: HIV and Substance Use
Hill K, Kuo I, Shenoi S, Desruisseaux M, Springer S. Integrated Care Models: HIV and Substance Use. Current HIV/AIDS Reports 2023, 20: 286-295. PMID: 37698755, PMCID: PMC11034717, DOI: 10.1007/s11904-023-00667-9.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health Care, IntegratedHealth ServicesHIV InfectionsHumansOpioid-Related DisordersConceptsSubstance use disordersUse disordersSubstance useIntegrated careRecent HIV outbreaksHIV viral suppressionMultidisciplinary care teamHIV virologic suppressionOpioid use disorderRisk of HIVHarm reduction programsSubstance use treatmentEvidence-based strategiesVirologic suppressionViral suppressionHIV outbreakCare teamProvider trainingHIVOnward transmissionHealth outcomesCare servicesClinic leadershipCare integrationMedical literaturePoor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia
Wong H, Wong P, Bador M, Chong M, Shenoi S, Rozanova J, Omar S, Neelamegam M, Lee Y, Rajasuriar R. Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 64-72. PMID: 36716735, DOI: 10.1097/qai.0000000000003169.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsiaCD4 Lymphocyte CountHIV InfectionsHumansKaplan-Meier EstimateProportional Hazards ModelsRetrospective StudiesConceptsNew HIV diagnosesHIV diagnosisOlder adultsLate presentationYoung adultsRetrospective analysisJoin-point regression analysisAntiretroviral therapy initiationKaplan-Meier analysisNew HIV infectionsLog-rank testMalaya Medical CentreAnnual percent increaseMann-Whitney U testYoung key populationsResource-limited settingsAntiretroviral therapyTherapy initiationHIV infectionHIV testingHIV transmissionHeterosexual contactPoint regression analysisMedical CenterImmunological responseCommunity health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Andrews L, Shenoi S. Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa. African Journal Of AIDS Research 2023, 22: 131-135. PMID: 37337826, DOI: 10.2989/16085906.2023.2213213.Peer-Reviewed Original ResearchMeSH KeywordsAdultCommunity Health WorkersHIV InfectionsHumansNoncommunicable DiseasesSouth AfricaTuberculosisConceptsTuberculosis preventive therapyCommunity health workersLargest HIV epidemicCause of deathNon-communicable diseasesHealth workersPreventive therapyRural resource-limited settingsHigh TB incidence ratesFurther implementation researchTB incidence rateRate of referralResource-limited settingsMedian ageTreatment initiationHIV epidemicIncidence rateRural South AfricaHIVInfectious diseasesTuberculosisImplementation researchScreening resultsDiseasePatients
2022
Perceptions, preferences, and experiences of tuberculosis education and counselling among patients and providers in Kampala, Uganda: A qualitative study
Ayakaka I, Armstrong-Hough M, Hannaford A, Ggita JM, Turimumahoro P, Katamba A, Katahoire A, Cattamanchi A, Shenoi SV, Davis JL. Perceptions, preferences, and experiences of tuberculosis education and counselling among patients and providers in Kampala, Uganda: A qualitative study. Global Public Health 2022, 17: 2911-2928. PMID: 35442147, PMCID: PMC11005908, DOI: 10.1080/17441692.2021.2000629.Peer-Reviewed Original ResearchConceptsHIV clinicPatient knowledgeTuberculosis educationHealth workersPrimary care facilitiesFront-line providersPeer educator modelTB educationTB patientsBurden settingsMedication adherenceUndergoing evaluationCare facilitiesPatientsLack of timePeer educatorsCommunity-engaged researchClinicCounsellingFocus group discussionsTBAdherenceQualitative studyKampalaProviders
2021
Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study
Virata MD, Shenoi SV, Ladines-Lim J, Villanueva MS, Barakat LA. Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study. PLOS ONE 2021, 16: e0260251. PMID: 34851963, PMCID: PMC8635326, DOI: 10.1371/journal.pone.0260251.Peer-Reviewed Original ResearchConceptsOne-year retrospective cohort studyCohort of PWHNon-communicable comorbiditiesPredictors of hospitalizationRetrospective cohort studyChronic lung diseaseLikelihood of hospitalizationSingle-site experienceCOVID-19 infectionNon-communicable diseasesOutcomes of peopleCohort studyHIV diseaseOverall mortalityClinical outcomesLung diseaseCardiovascular diseaseHospitalizationCumulative burdenHIVLater timeframeDiseaseEarly epidemicPWHOutcomesFeasibility of a community‐based delivery model for HIV pre‐exposure prophylaxis among bar patrons in rural South Africa
Grammatico MA, Moll AP, Choi K, Springer SA, Shenoi SV. Feasibility of a community‐based delivery model for HIV pre‐exposure prophylaxis among bar patrons in rural South Africa. Journal Of The International AIDS Society 2021, 24: e25848. PMID: 34826363, PMCID: PMC8625837, DOI: 10.1002/jia2.25848.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisAlcohol Use Disorders Identification TestLargest HIV epidemicCommunity-based delivery modelPrEP uptakeHIV testingOdds ratioOral tenofovir disoproxil fumarate/emtricitabineTenofovir disoproxil fumarate/emtricitabineRural South AfricaHazardous drinkingDisoproxil fumarate/emtricitabineHIV pre-exposure prophylaxisUptake of PrEPHIV care cascadeRapid HIV testingAdjusted odds ratioYoung menRural KwaZulu-Natal ProvinceAlcohol use disorderSexual risk behaviorsDisorders Identification TestBar patronsPrEP deliveryPrEP initiatorsAn expanding HIV epidemic among older adults in Ukraine: Implications for patient-centered care
Rozanova J, Zeziulin O, Rich KM, Altice FL, Kiriazova T, Zaviryukha I, Sosidko T, Gulati K, Carroll C, Shenoi SV. An expanding HIV epidemic among older adults in Ukraine: Implications for patient-centered care. PLOS ONE 2021, 16: e0256627. PMID: 34591848, PMCID: PMC8483339, DOI: 10.1371/journal.pone.0256627.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioMortality rateCause standardized mortality ratioTime of diagnosisGeneral population ratesLate-stage HIVAge-matched groupHigh mortality ratePatient-centered careIncident HIVHIV diagnosisHIV testingHIV incidenceHIV treatmentHIV epidemicMortality ratioTreatment strategiesGeneral populationHIVMortality trendsAge groupsEECA countriesTreatment programSame calendar yearOlder peopleAlcohol Use and the Risk of Communicable Diseases
Morojele NK, Shenoi SV, Shuper PA, Braithwaite RS, Rehm J. Alcohol Use and the Risk of Communicable Diseases. Nutrients 2021, 13: 3317. PMID: 34684318, PMCID: PMC8540096, DOI: 10.3390/nu13103317.Peer-Reviewed Original ResearchConceptsCommunicable diseasesTreatment outcomesSevere acute respiratory syndrome coronavirus 2Respiratory infection/pneumoniaAcute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Alcohol useDisability-adjusted life yearsSyndrome coronavirus 2Poor treatment outcomesCOVID-19 infectionAlcohol use disorderGlobal health concernIndividual-level interventionsDifferent communicable diseasesTB deathsImmunodeficiency virusCoronavirus 2Severe illnessUse disordersPneumoniaHeavy drinkersLife yearsHIV researchTuberculosisThe Lived Experience of a Newly Diagnosed Older Person With HIV in Ukraine
Allen A, Zaviryukha I, Kiriazova T, Shenoi S, Rozanova J. The Lived Experience of a Newly Diagnosed Older Person With HIV in Ukraine. Qualitative Health Research 2021, 31: 2290-2303. PMID: 34414837, PMCID: PMC8930274, DOI: 10.1177/10497323211026914.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAgedHIV InfectionsHIV SeropositivityHumansSocial StigmaUkraineConceptsHIV diagnosisCare providersAntiretroviral therapy initiationPrimary care providersHealth care providersFear of stigmaTherapy initiationYounger patientsMiddle-income countriesHIV knowledgeLower riskNew diagnosisHigh mortalityOlder personsOlder peopleDiagnosisLittle dataHIVTraumatic eventsPatientsProvidersMortalityExpansion of a national differentiated service delivery model to support people living with HIV and other chronic conditions in South Africa: a descriptive analysis
Liu L, Christie S, Munsamy M, Roberts P, Pillay M, Shenoi SV, Desai MM, Linnander EL. Expansion of a national differentiated service delivery model to support people living with HIV and other chronic conditions in South Africa: a descriptive analysis. BMC Health Services Research 2021, 21: 463. PMID: 34001123, PMCID: PMC8127180, DOI: 10.1186/s12913-021-06450-z.Peer-Reviewed Original ResearchMeSH KeywordsChronic DiseaseHealth FacilitiesHIV InfectionsHumansNoncommunicable DiseasesSouth AfricaConceptsNon-communicable diseasesDifferentiated service delivery modelsChronic conditionsChronic diseasesCentral Chronic Medicine DispensingLargest antiretroviral therapy (ART) programmeService delivery modelsManagement of HIVType of medicationAntiretroviral therapy programsHIV service deliveryChronic disease conditionsResource-limited settingsMedicine DispensingMixed-methods evaluationDelivery modelHealth districtHealth facilitiesNoncommunicable diseasesHIVPatientsPatient volumeTherapy programMedicationsDisease“We’ve Got Our Own Beliefs, Attitudes, Myths”: A Mixed Methods Assessment of Rural South African Health Care Workers' Knowledge of and Attitudes Towards PrEP Implementation
Asabor EN, Lett E, Moll A, Shenoi SV. “We’ve Got Our Own Beliefs, Attitudes, Myths”: A Mixed Methods Assessment of Rural South African Health Care Workers' Knowledge of and Attitudes Towards PrEP Implementation. AIDS And Behavior 2021, 25: 2517-2532. PMID: 33763802, PMCID: PMC8450017, DOI: 10.1007/s10461-021-03213-z.Peer-Reviewed Original ResearchConceptsLocal healthcare workersHealthcare workersPrEP implementationHealth care workers' knowledgeHIV pre-exposure prophylaxisSkilled clinical staffPre-exposure prophylaxisImpact of HIVPrEP interventionsHIV prevalenceHCW roleClinical staffTravel burdenMixed-methods assessmentDisproportionate burdenHIVWorkers' knowledgeAdditional concernsSexual behaviorBlack South AfricansBarriers researchersPrEPRisk compensationBurdenImplementation scientistsStructural barriers to implementing recommended tuberculosis preventive treatment in primary care clinics in rural South Africa
Chandra DK, Moll AP, Altice FL, Didomizio E, Andrews L, Shenoi SV. Structural barriers to implementing recommended tuberculosis preventive treatment in primary care clinics in rural South Africa. Global Public Health 2021, 17: 555-568. PMID: 33650939, PMCID: PMC8410883, DOI: 10.1080/17441692.2021.1892793.Peer-Reviewed Original ResearchConceptsTuberculosis preventive treatmentPrimary healthcare clinicsTPT initiationWorld Health OrganizationAntiretroviral therapyPreventive treatmentRural South AfricaHIV/TB servicesBurden of HIVOnly independent correlatePrimary care clinicsClinic-level factorsPatient-level characteristicsPrimary care providersHealth Services frameworkEvidence-based strategiesQuality improvement strategiesTB servicesClinical factorsCare clinicsIndependent correlatesMedical recordsPromoting ActionCare providersHealthcare clinicsFactors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa
Ahmed AA, Grammatico M, Moll AP, Malinga S, Makhunga P, Charalambous S, Ladines-Lim JB, Jones J, Choi K, Shenoi SV. Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa. Global Health Action 2021, 14: 1979281. PMID: 34652990, PMCID: PMC8525921, DOI: 10.1080/16549716.2021.1979281.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesFemaleHealth PersonnelHIV InfectionsHumansMiddle AgedPrescriptionsSouth AfricaTuberculosisConceptsTuberculosis preventive therapyHealth care workersPrimary healthcare clinicsLower prescription ratesPrescription ratesRural South AfricaCare workersIsoniazid preventative therapyIncidence of tuberculosisCross-sectional studyGovernment district hospitalsPreventive therapyMedian ageMultivariable analysisPreventative therapyDistrict hospitalHealthcare clinicsHCW trainingPatient disclosureTPT useConsolidated FrameworkLogistic regressionImplementation researchSelf-reported dataPrescribers
2020
Mobility and structural barriers in rural South Africa contribute to loss to follow up from HIV care
Hannaford A, Moll AP, Madondo T, Khoza B, Shenoi SV. Mobility and structural barriers in rural South Africa contribute to loss to follow up from HIV care. AIDS Care 2020, 33: 1436-1444. PMID: 32856470, PMCID: PMC8043244, DOI: 10.1080/09540121.2020.1808567.Peer-Reviewed Original ResearchConceptsHIV careRural South AfricaHIV transmissionLongitudinal HIV careViral load suppressionRisk of tuberculosisRural settingsStructural barriersART discontinuationPill fatigueMedian durationMixed-methods evaluationART accessMajor precipitantFuture interventionsCareDistant clinicsPLWHFamily needsConvenience samplingSocial supportMethods evaluationLTFUDiscontinuationMajor contributorMobile Device Usage by Gender Among High-Risk HIV Individuals in a Rural, Resource-Limited Setting
Campbell BR, Choi K, Neils MG, Canan C, Moll A, Dillingham R, Shenoi SV. Mobile Device Usage by Gender Among High-Risk HIV Individuals in a Rural, Resource-Limited Setting. Telemedicine Journal And E-Health 2020, 27: 615-624. PMID: 32835638, PMCID: PMC8215405, DOI: 10.1089/tmj.2020.0218.Peer-Reviewed Original ResearchConceptsMHealth interventionsRural KwaZulu-NatalCare of HIVLack of circumcisionMultivariable logistic regressionMedical male circumcisionResource limited settingsHealthcare messagesCircumcision statusHIV counselingHIV individualsMiddle-income countriesCondomless sexMale circumcisionCondom useCommunity settingsLogistic regressionHIVYoung womenHealthcare interventionsUnderserved populationsKwaZulu-NatalHealth information seekingHealth informationInterventionSocial Support is Key to Retention in Care during Covid-19 Pandemic among Older People with HIV and Substance Use Disorders in Ukraine
Rozanova J, Shenoi S, Zaviryukha I, Zeziulin O, Kiriazova T, Rich K, Mamedova E, Yariy V. Social Support is Key to Retention in Care during Covid-19 Pandemic among Older People with HIV and Substance Use Disorders in Ukraine. Substance Use & Misuse 2020, 55: 1902-1904. PMID: 32666857, PMCID: PMC7523433, DOI: 10.1080/10826084.2020.1791183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnti-Retroviral AgentsBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19FemaleHealth PersonnelHIV InfectionsHumansMaleMiddle AgedPandemicsPneumonia, ViralRetention in CareSARS-CoV-2Social IsolationSocial SupportSubstance-Related DisordersSurveys and QuestionnairesUkraineConceptsSubstance use disordersUse disordersHuman immunodeficiency virus HIVCOVID-19 pandemicOlder peopleLay health workersSocial supportTreatment interruptionConclusions/Health workersSUD treatmentPharmacological approachesYears old accountTelehealth supportVirus HIVHIVOlder adultsDisordersSuch interventionsPhone surveyTherapyProvision of supportCOVID-19 lockdownPandemicOld account‘PrEP should be for men only’: Young heterosexual men’s views on PrEP in rural South Africa
Hannaford A, Lim J, Moll AP, Khoza B, Shenoi SV. ‘PrEP should be for men only’: Young heterosexual men’s views on PrEP in rural South Africa. Global Public Health 2020, 15: 1337-1348. PMID: 32207661, DOI: 10.1080/17441692.2020.1744680.Peer-Reviewed Original ResearchMeSH KeywordsAdultHeterosexualityHIV InfectionsHumansMaleMenPre-Exposure ProphylaxisRural PopulationSouth AfricaYoung AdultConceptsRural South AfricaSouth AfricaYoung men's perspectivesHeterosexual menCommunity-based servicesYoung heterosexual menMen's perspectivesPrevention servicesService delivery modelsMen's viewsHIV prevention servicesStructural barriersFemale partnersKey themesHIV prevention knowledgeGender-specific interventionsCasual sexual partnersDifferentiated service delivery modelsGaps persistHigh HIV risk behaviorHIV-negative heterosexual menHigh-risk sexual behaviorPre-exposure prophylaxisHigh attributable mortalityHIV risk behaviors
2019
Perceptions of HIV Preexposure Prophylaxis Among Young Pregnant Women from Rural KwaZulu-Natal, South Africa
Vazquez L, Moll AP, Kacin A, Ndlovu NE, Shenoi SV. Perceptions of HIV Preexposure Prophylaxis Among Young Pregnant Women from Rural KwaZulu-Natal, South Africa. AIDS Patient Care And STDs 2019, 33: 214-219. PMID: 31067125, PMCID: PMC6531897, DOI: 10.1089/apc.2018.0242.Peer-Reviewed Original ResearchConceptsYoung pregnant womenPreexposure prophylaxisPregnant womenHIV riskCondom useSexual partnersHIV preexposure prophylaxisLast monthPregnant women 18Rural South African womenSub-Saharan womenRural KwaZulu-NatalSouth African womenHIV acquisitionNonpregnant womenPrEP effectivenessPrEP knowledgeMean agePrEP rolloutPostpartum periodHIV preventionWomen 18HIV stigmaHigh riskMost women