2023
Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Andrews L, Shenoi S. Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa. African Journal Of AIDS Research 2023, 22: 131-135. PMID: 37337826, DOI: 10.2989/16085906.2023.2213213.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyCommunity health workersLargest HIV epidemicCause of deathNon-communicable diseasesHealth workersPreventive therapyRural resource-limited settingsHigh TB incidence ratesFurther implementation researchTB incidence rateRate of referralResource-limited settingsMedian ageTreatment initiationHIV epidemicIncidence rateRural South AfricaHIVInfectious diseasesTuberculosisImplementation researchScreening resultsDiseasePatients
2022
Perceptions, preferences, and experiences of tuberculosis education and counselling among patients and providers in Kampala, Uganda: A qualitative study
Ayakaka I, Armstrong-Hough M, Hannaford A, Ggita JM, Turimumahoro P, Katamba A, Katahoire A, Cattamanchi A, Shenoi SV, Davis JL. Perceptions, preferences, and experiences of tuberculosis education and counselling among patients and providers in Kampala, Uganda: A qualitative study. Global Public Health 2022, 17: 2911-2928. PMID: 35442147, PMCID: PMC11005908, DOI: 10.1080/17441692.2021.2000629.Peer-Reviewed Original ResearchConceptsHIV clinicPatient knowledgeTuberculosis educationHealth workersPrimary care facilitiesFront-line providersPeer educator modelTB educationTB patientsBurden settingsMedication adherenceUndergoing evaluationCare facilitiesPatientsLack of timePeer educatorsCommunity-engaged researchClinicCounsellingFocus group discussionsTBAdherenceQualitative studyKampalaProviders
2021
856. Barriers to PrEP Implementation among Patient-Facing Staff in Three Urban Clinics
Shenoi S, Sideleau R, McKay S, Aoun-Barakat L. 856. Barriers to PrEP Implementation among Patient-Facing Staff in Three Urban Clinics. Open Forum Infectious Diseases 2021, 8: 519-519. DOI: 10.1093/ofid/ofab466.1051.Peer-Reviewed Original ResearchPrEP implementationPrEP uptakeSafety of PrEPQualified health centersLack of insuranceMultidisciplinary team membersDuration of employmentGuidelines/protocolsPrEP efficacyPrEP servicesMedian durationPrEP useUrban clinicPrEP rolloutHealth centersSafety dataProvider trainingPatient outreachSide effectsSystemic barriersMultidisciplinary staffSexual riskPatientsBehavioral interventionsPrescribersThe Lived Experience of a Newly Diagnosed Older Person With HIV in Ukraine
Allen A, Zaviryukha I, Kiriazova T, Shenoi S, Rozanova J. The Lived Experience of a Newly Diagnosed Older Person With HIV in Ukraine. Qualitative Health Research 2021, 31: 2290-2303. PMID: 34414837, PMCID: PMC8930274, DOI: 10.1177/10497323211026914.Peer-Reviewed Original ResearchConceptsHIV diagnosisCare providersAntiretroviral therapy initiationPrimary care providersHealth care providersFear of stigmaTherapy initiationYounger patientsMiddle-income countriesHIV knowledgeLower riskNew diagnosisHigh mortalityOlder personsOlder peopleDiagnosisLittle dataHIVTraumatic eventsPatientsProvidersMortalityExpansion of a national differentiated service delivery model to support people living with HIV and other chronic conditions in South Africa: a descriptive analysis
Liu L, Christie S, Munsamy M, Roberts P, Pillay M, Shenoi SV, Desai MM, Linnander EL. Expansion of a national differentiated service delivery model to support people living with HIV and other chronic conditions in South Africa: a descriptive analysis. BMC Health Services Research 2021, 21: 463. PMID: 34001123, PMCID: PMC8127180, DOI: 10.1186/s12913-021-06450-z.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesDifferentiated service delivery modelsChronic conditionsChronic diseasesCentral Chronic Medicine DispensingLargest antiretroviral therapy (ART) programmeService delivery modelsManagement of HIVType of medicationAntiretroviral therapy programsHIV service deliveryChronic disease conditionsResource-limited settingsMedicine DispensingMixed-methods evaluationDelivery modelHealth districtHealth facilitiesNoncommunicable diseasesHIVPatientsPatient volumeTherapy programMedicationsDisease
2020
1656. Factors associated with low TB preventative therapy prescription rates among healthcare workers in rural South Africa
Ahmed A, Grammatico M, Malinga S, Makhunga P, Moll A, Ladines-Lim J, Jones J, Choi K, Shenoi S. 1656. Factors associated with low TB preventative therapy prescription rates among healthcare workers in rural South Africa. Open Forum Infectious Diseases 2020, 7: s816-s817. PMCID: PMC7778258, DOI: 10.1093/ofid/ofaa439.1834.Peer-Reviewed Original ResearchPrimary care clinicsLower prescription ratesPrescription ratesHealthcare workersPatients' nondisclosureRural South AfricaConclusions Healthcare workersIsoniazid preventive therapyProfessional nursesRural district hospitalMedical officersCross-sectional surveyEligible patientsMortality benefitPreventive therapyMedian ageCare clinicsPreventative therapyTuberculosis incidenceDistrict hospitalSelf-reported knowledgePatientsHCW trainingMultivariate analysisPrescribersAttenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib
Foss FM, Rubinowitz A, Landry ML, Isufi I, Gowda L, Seropian S, Perreault S, Shenoi SV. Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib. Clinical Lymphoma Myeloma & Leukemia 2020, 20: 720-723. PMID: 32727701, PMCID: PMC7316063, DOI: 10.1016/j.clml.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunocompromised HostLymphoma, T-CellMaleMiddle AgedNitrilesPandemicsPneumonia, ViralPyrazolesPyrimidinesSARS-CoV-2Severity of Illness IndexTransplantation, HomologousTreatment OutcomeConceptsAllogeneic hematopoietic stem cell transplant patientsHematopoietic stem cell transplant patientsSevere acute respiratory syndrome coronavirus 2SARS coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2 pneumoniaAcute respiratory syndrome coronavirus 2Stem cell transplant patientsSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Coronavirus 2 infectionCell transplant patientsCoV-2 infectionStem cell transplantationSyndrome coronavirus 2High death rateImmunocompromised stateJAK/STAT inhibitor ruxolitinibTransplant patientsCell transplantationCoronavirus 2Novel therapiesInhibitor ruxolitinibPatientsDeath rateRuxolitinib
2017
Predictors of loss to follow-up among patients on ART at a rural hospital in KwaZulu-Natal, South Africa
Arnesen R, Moll AP, Shenoi SV. Predictors of loss to follow-up among patients on ART at a rural hospital in KwaZulu-Natal, South Africa. PLOS ONE 2017, 12: e0177168. PMID: 28542309, PMCID: PMC5443492, DOI: 10.1371/journal.pone.0177168.Peer-Reviewed Original ResearchConceptsPrimary health clinicsPredictors of lossART clinicsSouth African HIV clinicAntiretroviral therapy accessInadequate medical recordsCells/μLART initiationLow CD4LTFU ratesCD4 countHIV careHIV clinicHIV outcomesRetrospective reviewMedical recordsHealth clinicsTherapy accessHigh riskLTFUPatientsRural hospitalsRural South AfricaNovel interventionsClinic“It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa
Jacobson KB, Niccolai L, Mtungwa N, Moll AP, Shenoi SV. “It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa. AIDS Care 2017, 29: 936-942. PMID: 28147705, PMCID: PMC5545149, DOI: 10.1080/09540121.2017.1283390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory Care FacilitiesAntitubercular AgentsCounselingFemaleHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHIV InfectionsHumansIncidenceInterviews as TopicIsoniazidMalePatient ComplianceQualitative ResearchRural PopulationSocial StigmaSouth AfricaTrustTuberculosisConceptsIsoniazid preventive therapyIPT completionPreventive roleAbsence of symptomsHealth care workersKnowledge of TBHealth service deliveryResource-limited settingsHealth care systemRural KwaZulu-NatalAntiretroviral therapyHIV patientsHIV diagnosisPreventive therapyTherapy completionTB incidenceAppropriate counselingHealthcare workersIndividual patientsCare workersRural South AfricaHIVPatientsUnrelated conditionsIndividual semi-structured interviews
2016
Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa
Gilbert JA, Shenoi SV, Moll AP, Friedland GH, Paltiel AD, Galvani AP. Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa. PLOS ONE 2016, 11: e0165614. PMID: 27906986, PMCID: PMC5131994, DOI: 10.1371/journal.pone.0165614.Peer-Reviewed Original ResearchConceptsTB/HIVTB/HIV controlHIV screeningHIV controlRural South AfricaLife yearsMonths of IPTMost life yearsHigh-incidence settingsWidespread prevalenceCost-effectiveness resultsProbabilistic sensitivity analysesHIV transmissionHigh burdenTreatment coverageUnknown patientsHIVHealthcare accessDrug resistanceActive casesMonthsLifetime usePatientsYearsScreening
2014
1698Characteristics and Outcomes Among Patients with MDR-TB Treated in a Decentralized Community-based Treatment Program in Rural KZN, South Africa
Jacobson K, Eksteen F, Moll A, Friedland G, Mngadi A, Larkan L, Mhlongo P, Shenoi S. 1698Characteristics and Outcomes Among Patients with MDR-TB Treated in a Decentralized Community-based Treatment Program in Rural KZN, South Africa. Open Forum Infectious Diseases 2014, 1: s454-s454. DOI: 10.1093/ofid/ofu052.1244.Peer-Reviewed Original ResearchDisseminated tuberculosis manifesting as cholestasis in a patient with AIDS: a presentation to remember
Lee TM, Shenoi SV, Ogbuagu O. Disseminated tuberculosis manifesting as cholestasis in a patient with AIDS: a presentation to remember. BMJ Case Reports 2014, 2014: bcr2013201824. PMID: 24567181, PMCID: PMC3939406, DOI: 10.1136/bcr-2013-201824.Peer-Reviewed Case Reports and Technical NotesConceptsDisseminated tuberculosisCT scanChronic untreated HIV infectionSubsequent CT scanUntreated HIV infectionGeneXpert PCRMiliary infiltratesUnremarkable workupInduced sputumPersistent feverCholestatic jaundiceHIV infectionInfectious etiologyLiver diseasePleural effusionUnusual presentationTuberculosisCholestasisMycobacterium tuberculosisWeight lossJaundicePatientsIndian descentAIDSPresentation
2013
Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion
Zapata HJ, Villanueva M, Shenoi S. Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion. BMJ Case Reports 2013, 2013: bcr2013201184. PMID: 24248316, PMCID: PMC3841407, DOI: 10.1136/bcr-2013-201184.Peer-Reviewed Case Reports and Technical NotesConceptsForearm lesionPatient underwent incisionHIV viral loadMonths of treatmentSignificant medical problemHIV/AIDSEmpiric antibioticsAntiretroviral therapyCD4 countUnderwent incisionInitial diagnosisViral loadStarry stainImmunohistochemistry testingCopies/Bacillary angiomatosisHispanic menMedical problemsLesionsBartonella quintanaCells/PatientsMenHIVAngiomatosisNatural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
Lygizos M, Shenoi SV, Brooks RP, Bhushan A, Brust J, Zelterman D, Deng Y, Northrup V, Moll AP, Friedland GH. Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa. BMC Infectious Diseases 2013, 13: 300. PMID: 23815441, PMCID: PMC3716713, DOI: 10.1186/1471-2334-13-300.Peer-Reviewed Original ResearchConceptsTB transmission riskInfectious TB patientsTransmission riskTB patientsRural South AfricaDrug-resistant TBTB control effortsHealth care facilitiesPaucity of dataHousehold settingsRural KwaZulu-NatalPrevalent TBResistant TBTB transmissionCare facilitiesMultivariate analysisHIV areasVentilationAChSignificant decreaseWells-Riley equationPatientsRiskLow ventilationHour period‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis
Shenoi SV, Brooks RP, Catterick K, Moll AP, Friedland GH. ‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis. Public Health Action 2013, 3: 46-50. PMID: 25392815, PMCID: PMC4226409, DOI: 10.5588/pha.12.0056.Peer-Reviewed Original ResearchGeneral medical clinicDrug-resistant tuberculosisMedical clinicsClinic attendeesTB suspectsHuman immunodeficiency virus (HIV) patientsHigh HIV prevalence settingsZiehl-NeelsenProportion of patientsHIV prevalence settingsCulture-positive casesResource-limited settingsWorld Health OrganizationTB screeningVirus patientsHigh HIVResistant tuberculosisPatient populationTB prevalencePrevalence settingsReferral laboratoryTuberculosisDrug resistancePatientsClinic
2012
Survival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa
Shenoi SV, Brooks RP, Barbour R, Altice FL, Zelterman D, Moll AP, Master I, van der Merwe TL, Friedland GH. Survival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa. PLOS ONE 2012, 7: e31786. PMID: 22412840, PMCID: PMC3295798, DOI: 10.1371/journal.pone.0031786.Peer-Reviewed Original ResearchConceptsXDR-TB patientsDrug-resistant tuberculosisRetrospective case-control studyXDR-TB casesCommunity-based hospitalCase-control studyGlobal public healthHIV coinfectionMicrobiological correlatesModifiable factorsAvailable interventionsRural South AfricaControl studyPatientsTuberculosisPublic healthSurvivorsSurvivalDaysHospitalMortality
2009
Multidrug-resistant and extensively drug-resistant tuberculosis: consequences for the global HIV community
Shenoi S, Heysell S, Moll A, Friedland G. Multidrug-resistant and extensively drug-resistant tuberculosis: consequences for the global HIV community. Current Opinion In Infectious Diseases 2009, 22: 11-17. PMID: 19532076, PMCID: PMC3013226, DOI: 10.1097/qco.0b013e3283210020.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisHIV patientsHIV communityIntegration of tuberculosisIndependent risk factorCourse of treatmentCommunity-based treatmentHIV careNew rapid diagnosticsRisk factorsClinical careNegative individualsTuberculosisPatientsMultidrugRapid diagnosticsCareTreatmentSusceptibility informationMorbidityHIVInfectionMortalityPhysicians